Abstract：
:Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period.
journal_name
Brain Resjournal_title
Brain researchauthors
Soiza-Reilly M,Fossati M,Ibarra GR,Azcurra JMdoi
10.1016/j.brainres.2004.01.050subject
Has Abstractpub_date
2004-04-09 00:00:00pages
217-21issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304001684journal_volume
1004pub_type
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