Abstract:
:Electrical stimulation of the brain, particularly in the periventricular grey areas, caused long-lasting increases in behavioural escape thresholds to heating and mechanical stimuli applied to the facial region of the rat. The brain stimulation selectively suppressed responses to noxious stimuli. Responses to non-noxious stimuli, evoked by low threshold brush, were unaffected. The same animals that were studied in the behavioural tests were then anaesthetized with urethane and the inhibitory effect of the same brain stimulation was studied in single neurones recorded in the caudal trigeminal nucleus. A clear correlation (rs = 0.63) emerged between degree of behavioural antinociception and the amount of inhibition seen in nociceptive neurones. In addition the mean duration of the inhibition (6 min) was similar to the mean duration of the antinociceptive effect (7.3 min). Other classes of non-nociceptive neurones were unaffected by the stimulation. The neurones were also studied using iontophoretically applied monoamine candidates for the inhibitory neurotransmitter noradrenaline (NA) and 5-hydroxytryptamine (5-HT). The profile of the effects of NA most closely fitted that of the inhibitory neurotransmitter. This profile was expressed in terms of depression and excitation of different classes of neurones, and by the duration of effects. The depressants effects could be antagonized by iontophoretic idazoxan. In addition clonidine induced long-lasting depression of firing. 5-HT was more likely than NA to excite nociceptive neurones and to depress non-nociceptive neurons. Only NA consistently elevated thermal response thresholds in a similar manner to that produced by brain stimulation. These results provide some support for the hypothesis that selective descending inhibition of nociceptive responses in neurones of the rat caudal trigeminal nucleus is mediated by NA, possibly by an action at alpha2-adrenoceptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Cahusac PM,Morris R,Hill RGdoi
10.1016/0006-8993(95)00927-isubject
Has Abstractpub_date
1995-11-27 00:00:00pages
70-82issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00927-Ijournal_volume
700pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Highly specific antibodies to dynorphin A(1-13), infused into the lateral ventricle, elevated brain stimulation threshold for eliciting feeding behavior. Antibodies to beta-endorphin had little or no effect. Temporal analysis of the anorectic action indicated a striking similarity to the effect of systemically adminis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90950-4
更新日期:1987-10-06 00:00:00
abstract::Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotransmitter dysregulations within mesolimbic system. Adenosine 5'-triph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.05.025
更新日期:2019-09-15 00:00:00
abstract::Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02526-5
更新日期:2003-05-30 00:00:00
abstract::Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91312-3
更新日期:1992-10-16 00:00:00
abstract::The behavioral and physiological effects of electrical stimulation of the nucleus locus coeruleus (LC) were studied in the awake rat. LC electrodes consistently supported high rates of self-stimulation (SS). LC stimulation also inhibited spontaneous cellular discharges in the hippocampus (HPC). Both the LC-induced inh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90140-2
更新日期:1976-05-14 00:00:00
abstract::The blood-brain barrier (BBB) prevents many drugs from entering the brain. Yet, conventional methods that open the BBB are technically demanding, poorly reversible, and can be associated with long-term adverse effects. In comparison, carbogen, which is introduced nearly a century ago as a treatment for psychiatric dis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146320
更新日期:2019-10-01 00:00:00
abstract::Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90084-3
更新日期:1988-01-01 00:00:00
abstract::Some afferent fibers from the pudendal nerve of the female cat were stimulated by pressing on the perineal skin, the vagina or the uterine cervix. Three different types of skin mechanoreceptors were found: (1) with low threshold (< 20 mg) and slow-adapting discharges; (2) with high threshold (0.1-0.5 g) and slow-adapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91589-x
更新日期:1994-08-29 00:00:00
abstract::Nesfatin-1, an 82-amino acid peptide encoded by the secreted precursor nucleobinin-2 (NUCB2), exerts potent anorexigenic action independently of leptin signaling. This propensity has propelled this peptide and its analogues as potential anti-obesity drug candidates. However, a more extensive comprehension of its biolo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.01.032
更新日期:2019-05-15 00:00:00
abstract::Rats were bilaterally olfactory bulbectomized. At 15 days post-lesion, olfactory bulbectomized (OB) rats exhibited significant deficits in the acquisition of passive avoidance learning compared to sham lesioned rats. beta-Adrenoceptor binding in the amygdala, hippocampus and cerebral cortex was assayed with (-)-[125I]...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90783-8
更新日期:1990-10-29 00:00:00
abstract::The thalamic paraventricular nucleus (PVT) receives afferents from numerous brain areas, including the hypothalamic suprachiasmatic nucleus (SCN), considered to be the major circadian pacemaker. The PVT also sends projections to the SCN, limbic system centers and some nuclei involved in the control of the Sleep-Wake c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.09.017
更新日期:2008-11-19 00:00:00
abstract::The role of the substantia innominata (SI) in the generation of a behavior mediated by the prefrontal (PF) cortex was examined in two Japanese monkeys. PF neuronal activities related to a visual tracking task by wrist movement were recorded and neural responses to SI stimulation were analyzed. Sixty-six neurons showed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90734-5
更新日期:1983-10-16 00:00:00
abstract::Rat hippocampal slices were incubated with [3H]uridine in vitro to analyze the metabolism of nuclear RNA and the RNA precursor fractions. Labeling of total nuclear RNA was linear for 4 h of incubation and proportional to the concentration of labeled uridine in the incubation medium. Addition of 3.5 X 10(-8) M corticos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90375-5
更新日期:1984-07-23 00:00:00
abstract::The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90646-3
更新日期:1986-11-12 00:00:00
abstract::Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron numbe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02365-5
更新日期:2003-05-09 00:00:00
abstract::The amplitude of the acoustic startle reflex can be modulated by exposure to aversive stimuli or other conditions which evoke a state of fear. The neurotransmitters involved in this modulation are currently being investigated. Unilateral local infusion of corticotropin-releasing hormone (CRH; 0, 10, 20, 40 and 80 ng) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01309-7
更新日期:1998-01-26 00:00:00
abstract::In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.077
更新日期:2005-10-12 00:00:00
abstract::To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90364-0
更新日期:1984-07-23 00:00:00
abstract::Opioid-binding cell adhesion molecule (OBCAM) is the member of the IgLON family, a subgroup of the immunoglobulin superfamily. In the present study, the functions and dynamics of OBCAM were investigated in hippocampal neurons in vitro. Western blotting revealed that OBCAM expression was low at early stages of culture ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.062
更新日期:2007-08-24 00:00:00
abstract::In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90331-1
更新日期:1978-09-29 00:00:00
abstract::We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.103
更新日期:2006-07-12 00:00:00
abstract::The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00522-r
更新日期:1995-08-07 00:00:00
abstract::Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.031
更新日期:2005-03-21 00:00:00
abstract::The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90207-9
更新日期:1976-06-25 00:00:00
abstract::A pair of adult molluscan neurons (L5 and R5) are known to sprout and form a new electrical synapse following axotomy. Additionally, certain forms of stress can elicit restricted sprouting of neurons L5 and R5 within the intact nervous system. This study found that the strength of 5-5 electrical coupling was increased...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90759-0
更新日期:1985-09-23 00:00:00
abstract::A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91257-s
更新日期:1993-02-19 00:00:00
abstract::Quantitative autoradiographic analysis was used to identify regions in the brain of the male primate where androgen binding sites may be involved in the actions of testosterone. Three days after castration, adult male rhesus monkeys received a subcutaneous injection of either dihydrotestosterone propionate (DHTP, 20 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90456-3
更新日期:1989-11-13 00:00:00
abstract::The potential evoked at the surface of the cerebral cortex of a guinea pig, by stimulation of the contralateral forepaw, usually consists of an initial double positive wave whose waveform remains unchanged during rapid stimulation. In a guinea pig with experimental allergic encephalomyelitis (EAE) the response is atte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90350-9
更新日期:1975-08-08 00:00:00
abstract::Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction protein. We demonstrate here that similar alterations occur when nitrocel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00337-p
更新日期:1995-06-12 00:00:00
abstract::Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91576-e
更新日期:1993-03-19 00:00:00