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Localization of [3H]cyclohexyladenosine and [3H]nitrobenzylthioinosine binding sites in rat striatum and superior colliculus.

Abstract：

:The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly reduced the number (Bmax) of a single class of high affinity binding sites for [3H]CHA by 50% and that for [3H]NBI by 15% without altering Kd values for either ligand. In SC, enucleations significantly reduced both high and low affinity [3H]CHA binding sites by about 60% while levels of [3H]NBI binding were unaffected. Thus, adenosine receptors are present on striatal interneurons and retinal projections to the SC and some [3H]NBI binding sites are located on striatal interneurons.

journal_name

Brain Res

journal_title

Brain research

authors

Geiger JD

doi

10.1016/0006-8993(86)91033-4

subject

Has Abstract

pub_date

1986-01-22 00:00:00

pages

404-7

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)91033-4

journal_volume

363

pub_type

杂志文章

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