Abstract：
:The pedunculopontine tegmental nucleus (PPT) has been implicated in the generation and/or maintenance of both active sleep (AS) and wakefulness (W). GABAergic neurons are present within this nucleus and recent studies have shown that these neurons are active during AS. In order to examine the role of mesopontine GABAergic processes in the generation of AS, the GABA(A) agonist muscimol and the GABA(A) antagonist bicuculline were microinjected into the PPT of chronic cats that were prepared for recording the states of sleep and wakefulness. Muscimol increased the time spent in AS by increasing the frequency and duration of AS episodes; this increase in AS was at the expense of the time spent in wakefulness. A decrease in PGO density during AS was also observed following the microinjection of muscimol. On the other hand, bicuculline decreased both AS and quiet sleep and increased the time spent in wakefulness. These data suggest that GABA acts on GABA(A) receptors within the PPT to facilitate the generation of AS by suppressing the activity of waking-related processes within this nucleus.
journal_name
Brain Resjournal_title
Brain researchauthors
Torterolo P,Morales FR,Chase MHdoi
10.1016/s0006-8993(02)02475-7subject
Has Abstractpub_date
2002-07-19 00:00:00pages
1-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302024757journal_volume
944pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In the present experiment we examined the effect of progesterone upon dopamine (DA) release induced by a direct infusion of unlabeled L-dihydroxyphenylalanine (L-DOPA) into the caudate nucleus of freely behaving rats. Ovariectomized rats were implanted with a push-pull cannula directed at the caudate nucleus and subje...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90150-9
更新日期：1989-08-07 00:00:00
abstract：:The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03012-8
更新日期：2001-11-16 00:00:00
abstract：:Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.09.056
更新日期：2011-12-02 00:00:00
abstract：:We investigated the effects of inverting facial contour (hair and chin) and features (eyes, nose and mouth) on processing for static and dynamic face perception using magnetoencephalography (MEG). We used apparent motion, in which the first stimulus (S1) was replaced by a second stimulus (S2) with no interstimulus int...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.091
更新日期：2011-04-06 00:00:00
abstract：:An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive affe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90798-5
更新日期：1986-08-06 00:00:00
abstract：:This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01700-x
更新日期：1999-08-07 00:00:00
abstract：:Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.002
更新日期：2019-02-01 00:00:00
abstract：:Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.02.049
更新日期：2016-10-15 00:00:00
abstract：:Recent studies suggest that 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, can have direct effects on blood vessels beyond their cholesterol-lowering effects. We investigated the effects of atorvastatin on the functional and structural properties of blood-brain barrier (BBB) and the act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.044
更新日期：2005-05-03 00:00:00
abstract：:Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90128-4
更新日期：1987-02-10 00:00:00
abstract：:This study investigated the long-lasting effects of chronic ethanol consumption on the distribution of Schaffer collateral-commissural (SCH/COM) afferents within stratum radiatum of rat hippocampal CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special die...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90559-5
更新日期：1982-04-08 00:00:00
abstract：:The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91500-3
更新日期：1986-11-29 00:00:00
abstract：:The role of perceptual load in selective attention to multidimensional objects was investigated by independently manipulating the load along the task-relevant and the task-irrelevant dimensions in the central search array, which was flanked by congruent, incongruent, or neutral peripheral distractors. The relative bot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.071
更新日期：2006-10-09 00:00:00
abstract：:Monkeys made hemiparkinsonian by infusion of a solution of MPTP into one carotid artery appeared to ignore food presented from the contralateral side. Initial observations suggested neglect of visual stimuli presented as fruit treats by automated delivery system in the half-field contralateral to MPTP treatment. Furth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91080-k
更新日期：1991-02-08 00:00:00
abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90129-7
更新日期：1989-12-25 00:00:00
abstract：:Auditory stimulation applied during rapid eye movement (REM) sleep enhances the duration of REM sleep in cats and humans. The present experiment investigated whether auditory stimulation would enhance REM sleep in young (3-6 months) rats, and also in old (22-24 months) rats which have impaired REM sleep. Baseline slee...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91299-t
更新日期：1992-09-04 00:00:00
abstract：:In the present study we found that mesencephalic trigeminal (Mes-V) neurons of the rat are innervated by nitrergic fibers and that nitric oxide (NO) modifies the electrophysiological properties of these cells. Mes-V neurons were surrounded by a network of fibers that contained neuronal nitric oxide synthase (nNOS); th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03776-9
更新日期：2003-01-17 00:00:00
abstract：:When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91510-5
更新日期：1994-12-26 00:00:00
abstract：:High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90016-1
更新日期：1986-07-01 00:00:00
abstract：:Astrocytes and microglia in the spinal cord have recently been reported to contribute to the development of peripheral inflammation-induced exaggerated pain states. Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold to light tactile stimuli (mechanical allodynia) have bee...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02050-3
更新日期：2000-04-07 00:00:00
abstract：:The effects of spinal cord hemisection on protein labeling in the medulla, pons, midbrain, and cortex in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of brain. Animals were sacrificed 3, 6 or 13 days after hemisectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90458-9
更新日期：1977-02-25 00:00:00
abstract：:In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01625-x
更新日期：1999-07-31 00:00:00
abstract：:Previous research has shown that hippocampal and neocortical activation accompanies the postural changes occurring during self-grooming in rats but is absent or reduced during the stereotyped components of grooming, including head-washing and licking or biting. Since electrocortical activation is dependent on ascendin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01743-6
更新日期：1999-08-14 00:00:00
abstract：:The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91058-m
更新日期：1992-11-13 00:00:00
abstract：:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90306-2
更新日期：1983-07-25 00:00:00
abstract：:It has been suggested that the mechanism underlying the pain that occurs in patients with diabetic neuropathy may be similar to that mediating sympathetically maintained pain (SMP), such as occurs in patients with reflex sympathetic dystrophy. To evaluate this suggestion we have examined a model of diabetes mellitus, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90206-3
更新日期：1993-07-09 00:00:00
abstract：:Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90735-9
更新日期：1987-04-14 00:00:00
abstract：:Chronic administration of guanethidine to adult rats induces a selective autoimmune adrenergic neuropathy. Physiological and biochemical features of this disorder in the peripheral nervous system were explored in young adult Sprague-Dawley rats given daily intraperitoneal guanethidine monosulfate for 5 weeks. Control ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90720-2
更新日期：1988-09-27 00:00:00
abstract：:The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of potentially therapeutic proteins to motor neurons from the periphery following an intramuscular injection. The unique binding and transport properties of this 50-kDa polypeptide sugge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.007
更新日期：2004-06-11 00:00:00
abstract：:Freezing and escape responses induced by gradual increases in the intensity of the electrical current applied to dorsal regions of the periaqueductal gray (dPAG) cause a distinct pattern of Fos distribution in the brain. From these studies, it has been suggested that a pathway involving the dPAG itself, dorsomedial hy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.044
更新日期：2005-01-21 00:00:00
