Abstract：
:Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the depletion of dopamine (DA) or of norepinephrine (NE) is the critical factor for producing the impairments. In the present report methods to deplete brain catecholamine (CA) differentially were employed in order to test the hypothesis that central 6-OHDA injections act on brain CA substrates per se to produce behavioral and physiological response deficits to angiotensin II (ANG II) challenges. The findings support the interpretation that forebrain dopamine is essential for the mediation of sensorimotor integration involved in response to acute homeostatic stressors. In addition, the outcome identifies an important role for forebrain noradrenergic systems in the mediation of ANG II-elicited drinking and blood pressure responses.
journal_name
Brain Resjournal_title
Brain researchauthors
Bellin SI,Bhatnagar RK,Johnson AKdoi
10.1016/0006-8993(87)90128-4subject
Has Abstractpub_date
1987-02-10 00:00:00pages
105-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90128-4journal_volume
403pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The functional role of many central nervous structures has been inferred from the temporal relationship of a neuronal response with the different sensory and motor events in an experimental design such as when an animal performs a trained movement in response to a conditioned stimulus. However, this kind of data analy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90279-2
更新日期：1983-11-14 00:00:00
abstract：:The current study investigated the time course of the implicit processing of erotic stimuli using event-related potentials (ERPs). ERPs elicited by erotic pictures were compared with those by three other types of pictures: non-erotic positive, negative, and neutral pictures. We observed that erotic pictures evoked enh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.019
更新日期：2012-12-13 00:00:00
abstract：:Previous studies have demonstrated that some anticonvulsant drugs can modulate tolerance to the opioid analgesia. In the present study, the effects of lamotrigine (LTG) on the development and expression of tolerance to the morphine-induced antinociception were evaluated using tail-flick test. To assess the LTG effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.014
更新日期：2009-09-29 00:00:00
abstract：:Concurrent activation of dopamine D1 and D2 receptors (D1 and D2) is required for the expression of certain dopamine (DA)-mediated responses, such as climbing and stereotyped behaviors. Such interactions between D1 and D2 (i.e. D1/D2 synergism) represent an important aspect of dopaminergic function and plasticity. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04277-4
更新日期：2003-03-28 00:00:00
abstract：:In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01375-3
更新日期：1997-02-21 00:00:00
abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90185-6
更新日期：1994-02-04 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：:Radioautography was used to study the intraneuronal distribution of [3H]-serotonin (5-HT) and/or its derivatives selectively taken up by the olfactory bulb (OB) serotonergic terminals and subsequently transported to their parent cell bodies in the midbrain raphe nuclei. This was done 24 h after injection of [3H]5-HT i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90405-9
更新日期：1980-09-08 00:00:00
abstract：:Recent studies have supported the existence of projections to the paraventricular and supraoptic nuclei of the hypothalamus that arise from non-catecholaminergic neurons in the nucleus of the solitary tract, whose terminal distribution is suggestive of interactions with both parvocellular and magnocellular neurosecret...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00760-n
更新日期：1995-10-02 00:00:00
abstract：:We determined whether pentobarbital anesthetic is required to culture postmortem adult rat neurons. Pentobarbital treatment resulted in two-fold increases in neuron survival in culture after 2 and 4 h postmortem compared to non-anesthetic controls, but was not as effective as simple postmortem treatment on ice and the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.006
更新日期：2004-05-29 00:00:00
abstract：:In the adult brain, γ-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.003
更新日期：2012-11-27 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) receptor was solubilized from synaptic membrane of the rat brain by various detergents. Nonidet P-40, a non-ionic detergent, was found to be an effective solubilizing agent, since it caused no interference on the receptor binding assay, yielded a [3H]muscimol binding protein with a high ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90720-x
更新日期：1982-03-25 00:00:00
abstract：:We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00414-l
更新日期：1995-07-03 00:00:00
abstract：:Sera from patients with multiple sclerosis (MS) frequently produce demyelination of central nervous system tissue cultures. The nature of the factors responsible for demyelination is not as yet clearly established. However, several authors previously reported, in in vivo and in vitro models, demyelinating activity in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91075-8
更新日期：1979-01-19 00:00:00
abstract：:Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.035
更新日期：2018-11-15 00:00:00
abstract：:Bromodeoxyuridine (BrUdR) injected into Xenopus embryos at stages before, during or after the last period of DNA synthesis in Mauthner's neurons had no serious effect on differentiation of Mauthner's neurons. However, the BrUdR caused widespread cell degeneration in the central nervous system. The action of BrUdR on r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90819-3
更新日期：1978-07-21 00:00:00
abstract：:We examined the effect of the peripheral application of glutamate and capsaicin to the temporomandibular joint (TMJ) in influencing the activation and central sensitization of TMJ-responsive nociceptive neurons in the trigeminal subnucleus caudalis/upper cervical cord (Vc/UCC). The activity of single neurons activated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.056
更新日期：2009-02-09 00:00:00
abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90204-0
更新日期：1988-07-01 00:00:00
abstract：:Activation of a purinergic P2 receptor by adenosine 5'-triphosphate (ATP) has previously been shown to open a non-selective cation channel with a reversal potential of approximately 0 mV. We examined the effect of P2 receptor activation on voltage-gated ionic currents in acutely isolated CA3 pyramidal neurons from gui...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01588-4
更新日期：1996-04-09 00:00:00
abstract：:We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3-5 months old) and aged (22-24 months old) male Sprague-Dawley rats were tested in the hot plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays. Compared to young rats, aged rats displaye...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01960-0
更新日期：2000-03-10 00:00:00
abstract：:Percussion of the quadriceps tendon was used to test the hypothesis that knee extensor muscle spindle discharge initiates down-regulation of the gain of the soleus H reflex. Seven subjects participated. Soleus H reflex magnitude was observed for up to 15 s, following conditioning tendon taps of 60 N or 80 N force and ...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/0006-8993(95)00273-s
更新日期：1995-05-29 00:00:00
abstract：:In the previous study, we reported increased NOS expression in the astrocytes in the spinal cord of the transgenic mice that are used as ALS animal model. In the present study, we performed immunocytochemical studies to investigate the changes of nitrotyrosine-immunoreactivity in the brains of the transgenic mice, and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02302-1
更新日期：2000-01-17 00:00:00
abstract：:This study investigated the role of strain and vendor differences on the outcome of focal cerebral ischemia in the rat induced by occlusion of the middle cerebral artery by an intraluminal thread. The cortical infarct volumes (Mean +/- S.E.M.) were: 14.2 +/- 6.2 mm3 in Simonsen Laboratories Sprague-Dawley rats; 84.0 +...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00033-m
更新日期：1995-03-27 00:00:00
abstract：:The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91440-0
更新日期：1988-02-23 00:00:00
abstract：:Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01211-7
更新日期：1996-01-22 00:00:00
abstract：:The aim of this work was to study whether the vestibular afferent fibers establish direct connections with the motoneurons of glossopharyngeal and vagus nerves of the frog, Rana esculenta. In anaesthetized animals the vestibulocochlear nerve and the common root of glossopharyngeal-vagus and accessory (IX-X-XI) nerves ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.048
更新日期：2009-08-25 00:00:00
abstract：:A direct, although transient, projection from the sensorimotor cortex to the cerebellum has been described previously in the neonatal kitten. The present report demonstrates that this pathway can be induced to persist into juvenile stages of the cat by partially denervating the deep cerebellar nuclei. Most of the cere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80021-x
更新日期：1986-11-01 00:00:00
abstract：:The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03086-5
更新日期：2003-09-05 00:00:00
abstract：:We previously reported a model of acute cochlear energy failure using a mitochondrial toxin, 3-nitropropionic acid (3-NP), to study mechanisms of inner ear disorders such as inner ear ischemia. In this model, the main cause of hearing loss is apoptosis of fibrocytes in the cochlear lateral wall. Here, we analyzed the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.062
更新日期：2011-10-24 00:00:00
abstract：:The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.001
更新日期：2007-06-02 00:00:00
