Lesion of the ponto-geniculo-occipital pathways in kittens. I. Effects on sleep and on unitary discharge of the lateral geniculate nucleus.

abstract：:Interaural intensity and time differences (IID and ITD) are two binaural auditory cues for localizing sounds in space. This study investigated the spatio-temporal brain mechanisms for processing and integrating IID and ITD cues in humans. Auditory-evoked potentials were recorded, while subjects passively listened to n...

journal_title：Brain research

authors： Tardif E,Murray MM,Meylan R,Spierer L,Clarke S

更新日期：2006-05-30 00:00:00

abstract：:In the present study, we performed immunohistochemical studies to investigate the changes of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation. In contrast to the controls, a high density of Bcl-2-IR astrocytes were detected all around the gray matter of the spina...

journal_title：Brain research

authors： Shin CM,Chung YH,Kim MJ,Shin DH,Kim YS,Gurney ME,Lee KW,Cha CI

更新日期：2000-12-29 00:00:00

abstract：:The frequency-dependent effect of various anticonvulsant drugs on the conduction in central axons was studied in the corpus callosum of rat and guinea pig brain slices from the parietal region. Extracellularly recorded compound action potentials (CAPs) were evoked by either single stimulus or high frequency stimulatio...

journal_title：Brain research

authors： Silberstein E,Schleifstein-Attias D,Grossman Y

更新日期：1992-07-24 00:00:00

abstract：:The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of peripheral leukocytes. Astrocytes can respond to inflammatory cytokines like IL-1beta and TNF-alpha by producing chemokines. This study aims to test the ability of IL-1beta and ...

journal_title：Brain research

authors： Thompson WL,Van Eldik LJ

更新日期：2009-09-01 00:00:00

abstract：:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response ...

journal_title：Brain research

authors： Meder WP,Dooley DJ

更新日期：2000-09-01 00:00:00

abstract：:The influence of osmotic stimulation on the density of beta-adrenoceptor binding sites in the rat supraoptic nucleus (SON) was studied by quantitative autoradiography using 125I-cyanopindolol (ICYP). Increased density of beta-adrenoceptor binding sites was observed in osmotically stimulated rats and also after the sup...

journal_title：Brain research

authors： Lafarga M,Berciano MT,Del Olmo E,Andres MA,Pazos A

更新日期：1992-08-21 00:00:00

abstract：:The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of ...

journal_title：Brain research

authors： Moshé SL,Albala BJ

更新日期：1982-05-01 00:00:00

abstract：:The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC 3.4.11.8) (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...

journal_title：Brain research

authors： Busby WH Jr,Youngblood WW,Kizer JS

更新日期：1982-06-24 00:00:00

abstract：:DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form of DJ-1, was observed in PD patients. DJ-1-binding compound B, which ...

journal_title：Brain research

authors： Niki T,Endo J,Takahashi-Niki K,Yasuda T,Okamoto A,Saito Y,Ariga H,Iguchi-Ariga SMM

更新日期：2020-02-15 00:00:00

abstract：:Retinotectal projections were studied in 33 different species of Actinopterygii, the ray-finned fishes, with horseradish peroxidase and cobalt tracing techniques. The distribution of retinorecipient layers in the contralateral optic tectum was analyzed. In addition, the degree of differentiation of the stratum periven...

journal_title：Brain research

authors： von Bartheld CS,Meyer DL

更新日期：1987-09-15 00:00:00

abstract：:Intracellular recordings were made from neurons in the isolated myenteric plexus of the guinea-pig ileum. Methionine- and leucine-enkephalin were applied to the neurons either by adding them to the perfusing solution in known concentrations or be ejecting them by microiontophoresis. When applied in the perfusion solut...

journal_title：Brain research

authors： North RA,Katayama Y,Williams JT

更新日期：1979-04-06 00:00:00

abstract：:Factors underlying paired-pulse facilitation (PPF) were studied by intracellular and field recordings of CA1 neurons in the hippocampal slice in vitro, following stimulation of the Schaffer collaterals apical dendritic afferents. Similar magnitudes of PPF were found using the slopes or peaks of the excitatory postsyna...

journal_title：Brain research

authors： Leung LS,Fu XW

更新日期：1994-07-04 00:00:00

abstract：:The effects of glucagon like peptide-1 (GLP-1) on reflex swallowing were examined using anaesthetized rats. GLP-1 was injected into the dorsal vagal complex (DVC) using glass micropipettes. Swallowing was induced by repeated electrical stimulation of the central cut end of the superior laryngeal nerve (SLN) and was id...

journal_title：Brain research

authors： Kobashi M,Mizutani S,Fujita M,Mitoh Y,Shimatani Y,Matsuo R

更新日期：2017-09-15 00:00:00

abstract：:Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...

journal_title：Brain research

authors： Massarelli R,Stefanovic V,Mandel P

更新日期：1976-08-06 00:00:00

abstract：:The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was sensitive to lesions induced by focal cerebral ischemia. Sprague-Dawley rats were pre-screened for startle reflex responses 3-6 days prior to surgery and there were ...

journal_title：Brain research

authors： Maynard KI,Sukoff SJ,Ji Z,Wettstein JG,Black MD

更新日期：2005-01-25 00:00:00

abstract：:Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...

journal_title：Brain research

authors： McGaraughty S,Reinis S,Tsoukatos J

更新日期：1993-02-26 00:00:00

abstract：:Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...

journal_title：Brain research

authors： Sims TJ,Gilmore SA

更新日期：1997-07-18 00:00:00

abstract：:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...

journal_title：Brain research

authors： Sawchenko PE

更新日期：1987-12-29 00:00:00

abstract：:5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the regional density of binding to 5-HT receptors and transporters and the l...

journal_title：Brain research

authors： Park S,Harrold JA,Widdowson PS,Williams G

更新日期：1999-11-13 00:00:00

abstract：:The immunohistochemical distribution of substance P (SP) in the hypothalamic suprachiasmatic nucleus (SCN) was studied in adult male and female Djungarian hamsters (Phodopus sungorus) held under either long or short photoperiods. Intact animals were killed by perfusion with a fixative at the middle of the light or dar...

journal_title：Brain research

authors： Reuss S,Bürger K

更新日期：1994-02-28 00:00:00

abstract：:Brevetoxins (PbTx) are potent allosteric enhancers of voltage-gated sodium channel (VGSC) function and are associated with periodic "red tide" blooms. These neurotoxins produce neuronal injury and death in cerebellar granule cells (CGC) following acute exposure. In murine neocortical neurons, brevetoxin induces Ca(2+)...

journal_title：Brain research

authors： Dravid SM,Baden DG,Murray TF

更新日期：2005-01-07 00:00:00

abstract：:Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...

journal_title：Brain research

authors： Brenowitz GL,Collins WF 3rd,Erulkar SD

更新日期：1983-09-12 00:00:00

abstract：:Five complete poles of long nuclear chain intrafusal fibers of cat tenuissimus muscle spindles embedded in a plastic medium were cut in serial, 1 micron thick transverse sections and stained with toluidine blue. Each fiber pole displayed one plate-type motor ending positioned outside the encapsulated part of the spind...

journal_title：Brain research

authors： Kucera J,Hughes R

更新日期：1983-03-07 00:00:00

abstract：:Changes in the astrocytic cytoskeleton were examined in amygdala kindled rats using immunocytochemical techniques. One week following kindling, there was a dramatic increase in immunoreactivity to glial fibrillary acidic protein and vimentin in astrocytes throughout amygdala, pyriform cortex and hippocampus bilaterall...

journal_title：Brain research

authors： Khurgel M,Racine RJ,Ivy GO

更新日期：1992-10-02 00:00:00

abstract：:The regulation of corticosteroid receptor expression in the rat brain by adrenal steroids remains controversial. The results of in vivo studies [Brinton and McEwen, 1988; Luttge et al., 1989] suggest that activation of type I receptors can modulate both mineralocorticoid (MR; type I) and glucocorticoid (GR; type II) r...

journal_title：Brain research

authors： O'Donnell D,Meaney MJ

更新日期：1994-02-04 00:00:00

abstract：:Substance P(SP), the heptapeptide SP and the stable analogue (p-Glu5-MePhe8-MeGly9) SP (DiMe-C7) induce a Ca2+-dependent release of Met5-enkephalin (MET) from slices of periaqueductal gray matter (PAG) and striatum of rats. The MET release from striatal slices is greater than that from PAG slices because of the higher...

journal_title：Brain research

authors： Del Río J,Naranjo JR,Yang HY,Costa E

更新日期：1983-11-21 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...

journal_title：Brain research

authors： Levine J

更新日期：2016-05-01 00:00:00

abstract：:Twelve weeks after focal ventrolateral cerebrocortical suction lesions (ca. 12 X 4 mm) were made in rats, concentrations of the monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their metabolites were measured in several cortical and subcortical brain regions using high performance liquid chromat...

journal_title：Brain research

authors： Finklestein S,Campbell A,Baldessarini RJ,Moya KL,Haber SN

更新日期：1985-10-07 00:00:00

abstract：:Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunof...

journal_title：Brain research

authors： Ichikawa H,Sugimoto T

更新日期：2003-06-06 00:00:00

abstract：:Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...

journal_title：Brain research

authors： Czéh G,Horváth Z,Czopf J

更新日期：1990-06-04 00:00:00