Modulation of K(+)-induced synaptosomal calcium influx by gabapentin.


:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release.


Brain Res


Brain research


Meder WP,Dooley DJ




Has Abstract


2000-09-01 00:00:00














  • Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus.

    abstract::Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kow LM,Devidze N,Pataky S,Shibuya I,Pfaff DW

    更新日期:2006-10-20 00:00:00

  • The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures.

    abstract::We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gober MD,Laing JM,Thompson SM,Aurelian L

    更新日期:2006-11-13 00:00:00

  • Kappa-Opioid and NMDA glutamate receptors are differentially targeted within rat medial prefrontal cortex.

    abstract::Activation of kappa-opioid receptors (KOR) in the medial prefrontal cortex (mPFC) modulates excitatory transmission, which may involve interactions with N-methyl-D-aspartate (NMDA) glutamate receptors. We investigated possible anatomical correlates of this modulation by using dual labeling electron microscopy to exami...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Svingos AL,Colago EE

    更新日期:2002-08-16 00:00:00

  • Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. II. Distribution and characteristics of dopamine adenylate cyclase--interaction of d-LSD with dopaminergic receptors.

    abstract::The characteristics of dopamine adenylate cyclase in the rat striatum were first studied on homogenates of fresh tissues. In the assay conditions used, dopamine (10(-4) M) stimulated the enzyme activity by 250%. This effect was completely blocked by fluphenazine (10(-5) M; Ki=9X10(-9) M) and by phentolamine (10(-5) M;...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bockaert J,Premont J,Glowinski J,Thierry AM,Tassin JP

    更新日期:1976-05-07 00:00:00

  • Effects of fenfluramine and phentermine (fen-phen) on dopamine and serotonin release in rat striatum: in vivo microdialysis study in conscious animals.

    abstract::We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chron...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Balcioglu A,Wurtman RJ

    更新日期:1998-11-30 00:00:00

  • Lesions of the cerebellar interpositus nucleus abolish both nictitating membrane and eyelid EMG conditioned responses.

    abstract::Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lavond DG,Logan CG,Sohn JH,Garner WD,Kanzawa SA

    更新日期:1990-04-30 00:00:00

  • Expression of phenylethanolamine N-methyltransferase in sympathetic neurons and extraadrenal chromaffin tissue of chick embryos in vivo and in vitro.

    abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Teitelman G,Skaper S,Baker H,Park DH,Joh TH,Adler R

    更新日期:1984-04-01 00:00:00

  • Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs.

    abstract::Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (+/-)-SKF 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol) [DA D1-like]; bromocriptine, [DA D2 selective]; quinpirole, [DA D2/D3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-OH-DPAT), [DA D3/D2 preferr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cho S,Duchemin AM,Neff NH,Hadjiconstantinou M

    更新日期:1999-06-05 00:00:00

  • Experimental studies on the olfactory marker protein. I. Presence of the olfactory marker protein in tufted and mitral cells.

    abstract::Partial, unilateral olfactory nerve section was performed in mice, and the behavior of the olfactory marker protein (OMP) studied, after this experimental manipulation, with the peroxidase--antiperoxidase method. The protein, which in normal mice is present only in mature olfactory sensory neurons, after unilateral le...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Monti Graziadei GA,Graziadei PP

    更新日期:1981-03-30 00:00:00

  • Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.

    abstract::Cholinergic systems modulate synaptic transmission across the neuraxis and play an important role in higher brain function including cognition, arousal and nociception. The anterior cingulate cortex (ACC) is a fundamental brain region for nociception and chronic pain, and receives cholinergic projections mainly from b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Koga K,Matsuzaki Y,Migita K,Shimoyama S,Eto F,Nakagawa T,Matsumoto T,Terada K,Mishima K,Furue H,Honda K

    更新日期:2019-02-01 00:00:00

  • The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats.

    abstract::The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rybnikova E,Sitnik N,Gluschenko T,Tjulkova E,Samoilov MO

    更新日期:2006-05-17 00:00:00

  • Clorazepate synchronizes cultured rat C6 glioma in the early G1 phase of the cell cycle.

    abstract::A water soluble benzodiazepine, clorazepate, has been used to establish the point of benzodiazepine proliferative arrest in the rat C6 glioma. Clorazepate inhibited C6 proliferation in a dose-dependent manner with an IC50 value of 280 microM, as judged by a nuclei counting procedure. Release of cells from a 48 h expos...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maguire C,O'Connell C,Regan CM

    更新日期:1992-09-11 00:00:00

  • Pontine respiratory neurons in anesthetized cats.

    abstract::The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anest...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dick TE,Bellingham MC,Richter DW

    更新日期:1994-02-14 00:00:00

  • Chromatin binding of estradiol in the hypothalamus and cortex of male and female rats.

    abstract::Gonadal steroids are thought to act by activation of the genome following cytoplasmic binding, translocation of the hormone--receptor complex to the nucleus and chromatin binding at specific acceptor sites. This study examined the kinetics of chromatin binding of estradiol by hypothalamic and cortical cells of adult g...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Whalen RE,Olsen KL

    更新日期:1978-08-18 00:00:00

  • Survival of the ganglion cell population in the rabbit retina following neonatal visual cortex ablation.

    abstract::Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration doe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilkes M,Zingaro G,Murphy EH

    更新日期:1985-08-01 00:00:00

  • Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia.

    abstract::Vascular basement membrane (BM) stabilizes brain vessels and inhibits endothelial cell cycle. Cerebral ischemia causes BM breakdown with the loss of structural BM components including collagens and laminins. In this study, the expression changes of the BM proteoglycan agrin, and the non-structural BM constituent SPARC...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baumann E,Preston E,Slinn J,Stanimirovic D

    更新日期:2009-05-07 00:00:00

  • Protein phosphatase inhibitors prolong Ca(2+)-transients and divalent cation-dependent action potentials in leech Retzius cells.

    abstract::Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kleinhaus AL,Zeman RJ

    更新日期:1994-07-11 00:00:00

  • Ventral pontine catecholaminergic pathway mediates the vasopressin response to splanchnic osmostimulation in conscious rats.

    abstract::This study examines the role of catecholamines, cell bodies and fibers of passage within the subcoeruleus area (subLC) in the arginine vasopressin (AVP) response to splanchnic osmotic stimulation and hemorrhage. Bilateral chemical lesions were induced into the subLC, approximately 1 mm ventral to the locus coeruleus (...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: King MS,Baertschi AJ

    更新日期:1992-05-15 00:00:00

  • Synaptic transmission elevates adenosine 3', 5'-monophosphate (cyclic AMP) in locust neurosecretory cells.

    abstract::The release of adipokinetic hormones from the neurosecretory cells within the glandular lobe of the corpus cardiacum (CC) of locusts is under the synaptic control of axons within the nervi corporis cardiaca II (NCC II). This synapse has been shown to be aminergic with the transmitter tentatively identified as octopami...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Orchard I,Loughton BG,Gole JW,Downer RG

    更新日期:1983-01-03 00:00:00

  • Effects of sciatic nerve transplants after fimbria-fornix lesion: examination of the role of nerve growth factor.

    abstract::At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

    更新日期:1991-08-23 00:00:00

  • Extracellular K+ accumulation during penicillin-induced epileptogenesis in the CA3 region of immature rat hippocampus.

    abstract::Ion-selective microelectrode techniques were used to study extracellular K+ changes associated with penicillin-induced epileptogenesis in the CA3 region of hippocampal slices. Recordings were made in slices taken from rats 9-16 days of age, which have a pronounced capacity to undergo prolonged synchronized afterdischa...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Swann JW,Smith KL,Brady RJ

    更新日期:1986-12-01 00:00:00

  • Tectal input to the central posterior/prepacemaker nucleus of weakly electric fish, Apteronotus leptorhynchus: an in vitro tract-tracing study.

    abstract::The weakly electric fish Apteronotus leptorhynchus produces electric organ discharges which are highly stable in waveform and frequency. Short-term modulations of these discharges, typically displayed during social interactions, are controlled by the prepacemaker nucleus (PPn). Neurons of this thalamic cell group inte...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zupanc GK,Horschke I

    更新日期:1996-11-11 00:00:00

  • Quantitative analysis and postsynaptic targets of GABA-immunoreactive boutons within the rat trigeminal motor nucleus.

    abstract::We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Saha S,Appenteng K,Batten TF

    更新日期:1991-10-04 00:00:00

  • Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury.

    abstract::At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu X,Chung K,Chung JM

    更新日期:1999-12-04 00:00:00

  • Protection of oxidative preconditioning against apoptosis induced by H2O2 in PC12 cells: mechanisms via MMP, ROS, and Bcl-2.

    abstract::The present study is designed to investigate the effects of preconditioning with different doses of hydrogen peroxide (H2O2) on oxidative stress-induced apoptosis and the changes in mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) level, and expression of Bcl-2 during H2O2 preconditi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tang XQ,Feng JQ,Chen J,Chen PX,Zhi JL,Cui Y,Guo RX,Yu HM

    更新日期:2005-09-28 00:00:00

  • Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.

    abstract::The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bick RJ,Poindexter BJ,Kott MM,Liang YA,Dinh K,Kaur B,Bick DL,Doursout MF,Schiess MC

    更新日期:2008-06-27 00:00:00

  • Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity.

    abstract::The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ha JS,Dho SH,Youm TH,Kwon KS,Park SS

    更新日期:2014-11-24 00:00:00

  • Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease.

    abstract::Recent evidence suggest that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease (PD). In the present study, we have explored the motor effects of rimonabant, a selective antagonist of CB1 receptors, in a rat model of PD generated by an intracerebr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: González S,Scorticati C,García-Arencibia M,de Miguel R,Ramos JA,Fernández-Ruiz J

    更新日期:2006-02-16 00:00:00

  • K(v) channel interacting protein 3 expression and regulation by haloperidol in midbrain dopaminergic neurons.

    abstract::Antipsychotic drugs are the main treatment for schizophrenia, despite their adverse side effects and uncertain mode of action. Gene expression studies in the brains of rodents treated with antipsychotic drugs aim to uncover this mechanism and elucidate more specific targets for schizophrenia treatment. Previous expres...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Duncan CE,Schofield PR,Weickert CS

    更新日期:2009-12-22 00:00:00

  • Postural change and straining induced by distension of the rectum, vagina and urinary bladder of decerebrate dogs.

    abstract::In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fukuda H,Fukai K

    更新日期:1986-08-20 00:00:00