Abstract：
:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release.
journal_name
Brain Resjournal_title
Brain researchauthors
Meder WP,Dooley DJdoi
10.1016/s0006-8993(00)02610-xsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
157-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02610-Xjournal_volume
875pub_type
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