Abstract：
:Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for the inhibition of the uptake and some thermodynamic properties qould suggest a facilitated transport rather than an active uphill process. Preincubation of the cultures with various inhibitors of cholinesterases shows no direct parallelism between inhibition of choline high affinity uptake (apparent Km approximately equal to 10-6 M) and inhibition of ecto-acetylcholinesterase (EC 3.1.1.7).
journal_name
Brain Resjournal_title
Brain researchauthors
Massarelli R,Stefanovic V,Mandel Pdoi
10.1016/0006-8993(76)90337-1subject
Has Abstractpub_date
1976-08-06 00:00:00pages
103-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(76)90337-1journal_volume
112pub_type
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