Abstract:
:In order to explore the anatomical nature of the inhibitory GABAergic control of cerebral serotonergic neurons exerted at the level of the anterior raphé cells in the rat, we have studied the effect of GABA agonist agents (given systemically or infused locally into the raphé dorsalis or medianus) on cerebral 5-hydroxytryptophan (5-HTP) accumulation after lesion or pharmacological manipulation of various raphé inputs. Destruction of noradrenergic pathways by local injection of 6-hydroxydopamine in the pedunculus cerebellaris superior or by systemic injection of DSP-4 (50 mg/kg i.p.), or alteration of central dopaminergic transmission (by systemic administration of apomorphine or haloperidol) failed to modify the ability of progabide (400 mg/kg i.p.) or dipropylacetamide (150 mg/kg i.p.) to diminish 5-HTP accumulation in the striatum, hippocampus and substantia nigra. In contrast, electrolytic lesion of the habenular nuclei blocked the ability of these compounds (given systemically) to reduce 5-HTP accumulation both in serotonergic nerve terminal and cell body (raphé dorsalis and medianus) areas. A similar blockade of the effects of GABA mimetics was seen after ibotenate-induced lesion of the habenula but not after electrolytic lesion of the stria medullaris (which conveys most of the afferents to the habenula). Acute cessation of impulse flow in the habenulo-raphé tract also prevented the depamide-induced diminution of cerebral 5-HTP accumulation. Finally, interruption of nerve transmission in the habenulo-raphé pathways (by means of electrolytic lesion of the habenula or fasciculus retroflexus) blocked the ability of GABA (100 micrograms) or muscimol (50 ng) injected into the raphé dorsalis or medianus to reduce 5-HTP accumulation in the corresponding serotonergic nerve terminal areas. It is concluded that the GABAergic inhibition of ascending serotonergic neurons exerted in the raphé dorsalis and medianus depends upon an ongoing neuronal activity in the habenulo-raphé pathways; GABA may exert its inhibitory control over serotonergic neurons by tuning down a facilitatory influence on these cells exerted by the habenula.
journal_name
Brain Resjournal_title
Brain researchauthors
Nishikawa T,Scatton Bdoi
10.1016/0006-8993(85)90717-6subject
Has Abstractpub_date
1985-04-01 00:00:00pages
81-90issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)90717-6journal_volume
331pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We examined whether manipulations of fat metabolism influence the feeding response to peripheral or central administration of 5-thio-D-glucose (5-TG), a potent inhibitor of glucose utilization. The increase in food intake produced by peritoneal (50 mg/kg) or fourth ventricular (50, 100, 150 micrograms) 5-TG was potent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91181-x
更新日期:1988-04-05 00:00:00
abstract::Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01222-0
更新日期:1999-01-23 00:00:00
abstract::The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five major functional systems, namely the dorsal somatomotor basal ganglia; ventral viscerolimbic basal...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2011.09.037
更新日期:2011-11-18 00:00:00
abstract::The vascular changes in the hippocampus and neocortex during kainic acid-induced seizures were investigated in control rats and in rats with chronic, bilateral, cervical sympathectomy. Seizures were induced in unanesthetized, spontaneously breathing rats. The increase in blood flow in the hippocampus of the sympathect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91782-c
更新日期:1990-11-05 00:00:00
abstract::Previous studies focusing on the relationship between lateralization of language function and age suffer from lack of a balanced distribution of age and handedness among participants, especially in the extremes of age. This limits our understanding of the influence of these factors on lateralization of language circui...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.021
更新日期:2017-11-01 00:00:00
abstract::In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article, we select a few examples of recent advances in neuroscience and discuss their application or potential application to the study of motoneurons and the control of movemen...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2011.06.008
更新日期:2011-08-29 00:00:00
abstract::Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90244-6
更新日期:1990-08-27 00:00:00
abstract::In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00687-l
更新日期:1995-09-25 00:00:00
abstract::Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90471-6
更新日期:1976-01-23 00:00:00
abstract::We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02644-6
更新日期:2002-06-28 00:00:00
abstract::The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.044
更新日期:2007-07-09 00:00:00
abstract::Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90875-1
更新日期:1981-11-16 00:00:00
abstract::At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90147-n
更新日期:1991-08-23 00:00:00
abstract::The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91272-6
更新日期:1983-01-24 00:00:00
abstract::Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90203-5
更新日期:1989-02-20 00:00:00
abstract::Bilateral lesions of the amygdaloid complex in C57BL/6 mice prevented the occurrence of morphine-induced hypermotility (running fit). This effect, that was different from that observed after hippocampal lesions but similar to that observed after caudate lesions, confirms the role of the basal ganglia catecholaminergic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91328-0
更新日期:1989-02-06 00:00:00
abstract::An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90615-6
更新日期:1976-03-12 00:00:00
abstract::Long-term memory formation for passive-avoidance learning in the day-old chick is known to have two distinct time windows of protein synthesis (F.M. Freeman, S.P.R. Rose, A.B. Scholey, 1995. Two time windows of anisomycin-induced amnesia for passive-avoidance training in the day-old chick. Neurobiol. Learn. Mem. 63, 2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02181-8
更新日期:2000-05-12 00:00:00
abstract::The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90077-3
更新日期:1982-01-01 00:00:00
abstract::To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03285-6
更新日期:2001-03-02 00:00:00
abstract::The outgrowth region of the regenerating frog sciatic nerve shows an increased permeability for various drugs, which has been utilized for pharmacological studies of axonal transport. Six days after a bilateral crush lesion, the nerves, including the spinal ganglia, were incubated in a compartmented chamber. Orthograd...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91160-7
更新日期:1987-01-13 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90428-1
更新日期:1979-01-12 00:00:00
abstract::The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00151-0
更新日期:1997-04-11 00:00:00
abstract::A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90512-6
更新日期:1994-12-30 00:00:00
abstract::Retrograde axonal transport method of the fluorescent tracer FluoroGold (FG) was combined with immunocytochemistry to investigate the occurrence of nitric oxide synthase (NOS), somatostatin (SOM), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in both intrinsic and cortically projecting neurons of the ra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02408-8
更新日期:2001-06-29 00:00:00
abstract::Proactive motor response inhibition is used to strategically restrain actions in preparation for stopping. In this study, we first examined the event related potential (ERP) elicited by low and high level of proactive response inhibition, as assessed by the stop-signal task. Corroborating previous studies, we found an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147064
更新日期:2020-11-15 00:00:00
abstract::We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.03.021
更新日期:2019-04-15 00:00:00
abstract::Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.02.049
更新日期:2016-10-15 00:00:00
abstract::The functions of the claustrum are not well understood. Few studies explore its electrophysiological properties in awake animals. Here, we address this lacuna by recording spontaneous local field potential (LFP) activity in the anterior claustrum of rats freely exploring open field environments under differing conditi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.021
更新日期:2017-12-15 00:00:00
abstract::The concentrations of GABA, glutamate, aspartate, glycine, taurine, glutamine, asparagine and alanine were determined in the CSF of 10 Senegalese baboons (Papio papio) following initial ketamine anaesthesia and subsequent administration (4 h later) of different compounds known to alter either inhibitory or excitatory ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90370-b
更新日期:1991-01-04 00:00:00