Effects of sciatic nerve transplants after fimbria-fornix lesion: examination of the role of nerve growth factor.

abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

journal_title：Brain research

authors： Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

更新日期：2009-12-01 00:00:00

abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...

journal_title：Brain research

authors： Liu B,Guo Z,Dong H,Daofeng T,Cai Q,Ji B,Zhang S,Wu L,Wang J,Wang L,Zhu X,Liu Y,Chen Q

更新日期：2015-06-22 00:00:00

abstract：:We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...

journal_title：Brain research

authors： Copani A,Romano C,Di Giorgi Gerevini V,Nicosia A,Casabona G,Storto M,Mutel V,Nicoletti F

更新日期：2000-06-09 00:00:00

abstract：:Following codepletion of endogenous serotonin (5-HT, greater than 90%) and thyrotropin-releasing hormone (TRH, 66%) by neonatal treatment with the serotonergic neurotoxin, 5,7-dihydroxytryptamine (DHT), a 33% (n = 12, P less than 0.01) increase in specific TRH receptor binding was observed in adult rat spinal cord (SC...

journal_title：Brain research

authors： Sharif NA,Towle AC,Burt DR,Mueller RA,Breese GR

更新日期：1989-02-20 00:00:00

abstract：:Glutamate is the main excitatory neurotransmitter in the central nervous system. This amino acid mediates learning and memory processes acting through ionotropic and metabotropic receptor binding. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that stimulate phospholipase C (PLC) or inhibit ...

journal_title：Brain research

authors： Iglesias I,Castillo CA,León D,Ruíz MA,Albasanz JL,Martín M

更新日期：2007-06-11 00:00:00

abstract：:Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...

journal_title：Brain research

authors： Ichinose M,Byrne JH

更新日期：1991-05-17 00:00:00

abstract：:In the present experiment we use a rat model of traumatic brain injury to evaluate the ability of low-pressure hyperbaric oxygen therapy (HBOT) to improve behavioral and neurobiological outcomes. The study employed an adaptation of the focal cortical contusion model. 64 Male Long-Evans rats received unilateral cortica...

journal_title：Brain research

authors： Harch PG,Kriedt C,Van Meter KW,Sutherland RJ

更新日期：2007-10-12 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating subtypes of stroke. Since angiogenesis is a fundamental process to brain development and repair by new blood vessel formation from pre-existing ones, mediated by numerous angiogenic factors including vascular endothelial growth factor (VEGF), th...

journal_title：Brain research

authors： Tang T,Liu XJ,Zhang ZQ,Zhou HJ,Luo JK,Huang JF,Yang QD,Li XQ

更新日期：2007-10-17 00:00:00

abstract：:Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the l...

journal_title：Brain research

authors： Bonaz B,Martin L,Beurriand E,Hostein J,Feuerstein C

更新日期：1992-06-26 00:00:00

abstract：:Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...

journal_title：Brain research

authors： Sinatra RS,Ford DH

更新日期：1979-10-19 00:00:00

abstract：:N-desmethylclozapine (NDMC), a major circulating metabolite of the atypical antipsychotic drug, clozapine, and has M(1) muscarinic receptor partial agonistic property. The purpose of the present study was to examine whether in vivo behavioral effects of NDMC were elicited through the activation of muscarinic receptors...

journal_title：Brain research

authors： Maehara S,Hikichi H,Ohta H

更新日期：2011-10-18 00:00:00

abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

journal_title：Brain research

authors： Li J,Wurtman RJ

更新日期：1999-02-13 00:00:00

abstract：:The in vitro capacity of sympathetic superior cervical ganglia (SCG) to take up [3H]choline from the extracellular medium, to synthesize acetylcholine from [3H]choline, and to release [3H]acetylcholine in response to a high K+ concentration, were examined in rats throughout a 24-h cycle. Both the release of [3H]acetyl...

journal_title：Brain research

authors： González Burgos GR,Rosenstein RE,Cardinali DP

更新日期：1994-02-14 00:00:00

abstract：:Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...

journal_title：Brain research

authors： Czéh G,Horváth Z,Czopf J

更新日期：1990-06-04 00:00:00

abstract：:A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the c...

journal_title：Brain research

authors： Richardson RT,DeLong MR

更新日期：1986-12-10 00:00:00

abstract：:Stellate ganglion block (SGB) is a blockade of sympathetic ganglia innervating the head and neck, and is known to function through vasodilation of the target region. However, the effectiveness of SGB in relieving cerebral vasospasm (CVS) through dilation of intracerebral vessels has not been evaluated. The aim of the ...

journal_title：Brain research

authors： Hu N,Wu Y,Chen BZ,Han JF,Zhou MT

更新日期：2014-10-17 00:00:00

abstract：:During a recent study of the effects of photoreceptor degeneration on Muller cells, we observed that unlike glia from normal adult retinas, glia from degenerating rat retinas could be cultured and maintained in vitro for several weeks. Using a variety of cell type specific antisera, we show that at least 70% of cells ...

journal_title：Brain research

authors： Sarthy PV

更新日期：1985-06-24 00:00:00

abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...

journal_title：Brain research

authors： Galvez R,Gopal AR,Greenough WT

更新日期：2003-05-02 00:00:00

abstract：:The gustatory responses of the Mongolian gerbil were tested with 12 sugar alcohols. The electrophysiological effectiveness of the linear polyols as gustatory stimulants increased as the length of the carbon chain increased from 2 to 5. Six and 7 carbon acyclic polyols were no more effective than the pentitols. By comp...

journal_title：Brain research

authors： Jakinovich W Jr,Oakley B

更新日期：1976-07-16 00:00:00

abstract：:Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...

journal_title：Brain research

authors： Rosenbluth J,Tao-Cheng JH,Blakemore WF

更新日期：1985-12-09 00:00:00

abstract：:In urethane-anesthetized cats, ordinary and partial coherence values relating the 10-Hz rhythmic discharges of sympathetic nerves located on opposite sides of the body were not significantly affected by midsagittal section of the spinal cord from the seventh cervical through eighth thoracic or first cervical through e...

journal_title：Brain research

authors： Zhong S,Gebber GL,Barman SM

更新日期：1995-01-30 00:00:00

abstract：:The present study evaluated the ability of salicylic acid (SA) to attenuate long-term L-DOPA-induced 6-hydroxydopamine (6-OHDA) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. The production of 6-OHDA from dopamine in vitro from ferrous-ascorbate-dopamine (FAD) hydro...

journal_title：Brain research

authors： Borah A,Mohanakumar KP

更新日期：2010-07-16 00:00:00

abstract：:Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...

journal_title：Brain research

authors： Ter Maat A,Lodder JC,Veenstra J,Goldschmeding JT

更新日期：1982-05-13 00:00:00

abstract：:In the present experiment we tested the hypothesis that early interference with noradrenaline transmission can have permanent consequences for brain function in adulthood. Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal...

journal_title：Brain research

authors： Gorter JA,Kamphuis W,Huisman E,Bos NP,Mirmiran M

更新日期：1990-12-03 00:00:00

abstract：:Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. W...

journal_title：Brain research

authors： Dias Soares D,Fernandez F,Aguerre S,Foury A,Mormède P,Chaouloff F

更新日期：2003-01-24 00:00:00

abstract：:Cerebral cortex membranes from rats habituated to manipulations preceding decapitation (habituated rats) had 40% higher GABA binding than membranes from naive animals. Diazepam (5 X 10(-6) M), added to membranes from naive rats, increased GABA binding to the level of habituated rats, but failed to induce any further i...

journal_title：Brain research

authors： Biggio G,Concas A,Serra M,Salis M,Corda MG,Nurchi V,Crisponi C,Gessa GL

更新日期：1984-07-02 00:00:00

abstract：:The effect of different dose, mode and duration of estradiol administration was examined in the different brain catecholaminergic areas in ovariectomized (OVX) female rats. We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I...

journal_title：Brain research

authors： Serova LI,Maharjan S,Huang A,Sun D,Kaley G,Sabban EL

更新日期：2004-07-23 00:00:00

abstract：:Accumulating evidence suggests that dopamine (DA) neurons in the ventral tegmental area (VTA) contribute to the complex amygdala-based neurocircuitry that mediates fear-motivated behaviors. Because of acetylcholine's (ACh) role in DA neuronal activation, the involvement of VTA cholinergic muscarinic receptors in Pavlo...

journal_title：Brain research

authors： Greba Q,Munro LJ,Kokkinidis L

更新日期：2000-07-07 00:00:00

abstract：:The selective dopaminergic antagonist ligands [3H]SCH 23390 and [3H]sulpiride were used to reveal autoradiographically dopamine D1 and D2 receptors, respectively, in brain sections from rats which had received unilateral 6-hydroxydopamine (6-OHDA) injections destroying ascending nigrostriatal neurones. The binding of ...

journal_title：Brain research

authors： Graham WC,Crossman AR,Woodruff GN

更新日期：1990-04-23 00:00:00

abstract：:By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS). Further immunoblot analyses showed that the levels of CA II are increased not only in the brain of adult Ts65Dn mice but also in the brain of infants and young ch...

journal_title：Brain research

authors： Palminiello S,Kida E,Kaur K,Walus M,Wisniewski KE,Wierzba-Bobrowicz T,Rabe A,Albertini G,Golabek AA

更新日期：2008-01-23 00:00:00