Abstract：
:Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating subtypes of stroke. Since angiogenesis is a fundamental process to brain development and repair by new blood vessel formation from pre-existing ones, mediated by numerous angiogenic factors including vascular endothelial growth factor (VEGF), the goal of the present work is to establish whether there is cerebral angiogenesis in rat brains with collagenase-induced ICH. Investigations were also performed to evaluate whether ICH alters expression of VEGF and its receptors Flt-1 and Flk-1. ICH was induced on adult male Sprague-Dawley rats by stereotactic injection of collagenase type VII into right globus pallidus. Angiogenesis was identified by hematoxylin-eosin stain and double immunolabeling method, and expression of VEGF and the receptors was evaluated by immunohistochemistry and quantitative real time reverse transcription-polymerase chain reaction. New vessels appeared around the hematoma and extended into it from 7 days, and 5-Bromo-2-Deoxyuridine-labeled nuclei in cerebral endothelial cells resided around the hematoma and the labeling peaked from 7 to 14 days. Expression of VEGF, Flt-1 and Flk-1 was observed in cerebral endothelial cells at the hemorrhagic basal ganglion, and increases of their mRNA persisted to 28 days. These findings suggest that ICH can induce cerebral angiogenesis and upregulation of VEGF, Flt-1 and Flk-1 and that modulation of angiogenesis via altering expression of VEGF and its receptors may be a potential strategy for promoting ICH repair.
journal_name
Brain Resjournal_title
Brain researchauthors
Tang T,Liu XJ,Zhang ZQ,Zhou HJ,Luo JK,Huang JF,Yang QD,Li XQdoi
10.1016/j.brainres.2007.08.028subject
Has Abstractpub_date
2007-10-17 00:00:00pages
134-42eissn
0006-8993issn
1872-6240pii
S0006-8993(07)01801-Xjournal_volume
1175pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Androgens are involved in a variety of centrally mediated functions after binding to their intracellular receptors. In the present report, we have employed the androgen receptor antibody, PG-21, and indirect immunohistochemistry to examine the distribution of cells containing androgen receptor-like immunoreactivity (A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00983-3
更新日期：1995-12-12 00:00:00
abstract：:Prairie voles (Microtus ochrogaster) are monogamous rodents that display high levels of affiliative behaviors, including pair-bonding, biparental care, and cooperative breeding. Species differences in basal cocaine- and amphetamine-regulated transcript (CART) mRNA and peptide expression have been found between prairie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.040
更新日期：2011-09-26 00:00:00
abstract：:Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91096-1
更新日期：1987-05-19 00:00:00
abstract：:The pyrithiamine-treated rats produced by our method histopathologically exhibited the edematous lesion not only around the third ventricle and at the tegmentum of pons, as expected, but also in the cerebral cortex. These animals were, therefore, used in a biochemical study of the cerebral cortex, in particular, gluco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91399-6
更新日期：1988-02-16 00:00:00
abstract：:The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01234-6
更新日期：1997-01-16 00:00:00
abstract：:Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90291-8
更新日期：1977-02-18 00:00:00
abstract：:During functional spinal neural network activity motoneurons receive massive synaptic excitation and inhibition, and their membrane conductance increases considerably - they are switched to a high-conductance state. High-conductance states can substantially alter response properties of motoneurons. In the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.030
更新日期：2016-10-01 00:00:00
abstract：:The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically signif...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90311-5
更新日期：1981-08-31 00:00:00
abstract：:The present study was undertaken to investigate in rats the role of the noradrenergic innervation of the hippocampus in the reversal by antidepressant drugs of escape failures caused by previous exposure to inescapable shocks (learned helplessness design). Rats were either sham-operated or given a bilateral infusion o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91646-5
更新日期：1987-12-29 00:00:00
abstract：:A novel and convenient assay was used to determine the effect of recombinant Interleukin-2 (IL-2) on the function of the blood-brain barrier (BBB). The assay is based on a variant of the West Nile virus, WN-25, which had lost its neuroinvasiveness but not its neurovirulence. WN-25, when injected intravenously, can cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91079-2
更新日期：1989-09-04 00:00:00
abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.033
更新日期：2015-05-22 00:00:00
abstract：:The distribution of cortical neurons which project to the spinal cord was investigated in the developing and adult rat using the retrograde transport of horseradish peroxidase (HRP). Following injections of HRP into the cervical spinal cord of a postnatal day 4 rat, retrogradely labeled neurons are located in layer Vb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90161-5
更新日期：1984-04-01 00:00:00
abstract：:We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02777-9
更新日期：2001-09-21 00:00:00
abstract：:The behavioral and EEG effects of rat and ovine corticotropin releasing factor (r- and o-CRF) were compared. Both peptides were injected intracerebroventricularly into rats through chronically implanted cannulae. At the doses of 0.1 and 1 microgram both peptides activated the EEG and stimulated motor activity. At the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90413-6
更新日期：1987-04-07 00:00:00
abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90556-3
更新日期：1993-10-29 00:00:00
abstract：:The effects of cocaine administration and withdrawal on D1 and D2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90255-0
更新日期：1994-01-14 00:00:00
abstract：:The thalamic midline/intralaminar complex is part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways. The midline thalamic nuclei connect with the medial prefrontal cortex and the medial temporal lobe. On the other hand, the intralaminar nuc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.047
更新日期：2014-10-24 00:00:00
abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system. PACAP is also found in nerve fibers innervating the pineal gland, where it stimulates the secretion of the pinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03127-5
更新日期：2003-09-12 00:00:00
abstract：:Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90075-5
更新日期：1983-03-01 00:00:00
abstract：:After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.048
更新日期：2014-10-24 00:00:00
abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:Preferential uptake of dopamine occurred in mesocortical vs striatal synaptosomes obtained from acutely fighting isolated male ICR mice. Specifically, both Km and Vmax were significantly increased in the prefrontal cortex but not the caudate-putamen. The findings are similar to selective changes in mesocortical activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90954-9
更新日期：1981-10-05 00:00:00
abstract：:Antisense oligodeoxynucleotide (AS ODN) probes directed against the alpha-subunit of different G-proteins have been used to differentiate feeding responses in rats elicited by different opioid agonists, including morphine, beta-endorphin and dynorphin. Furthermore, antisense probes directed against G(o)alpha, but not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03361-9
更新日期：2002-11-15 00:00:00
abstract：:The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02687-7
更新日期：2001-08-24 00:00:00
abstract：:This study aimed at gaining insight into the role of the excitatory neurotransmitter glutamate in topographic map reorganization in the sensory systems of adult mammals after restricted deafferentations. Hereto, in vivo microdialysis was used to sample extracellular glutamate from sensory-deprived and non-deprived vis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04047-7
更新日期：2003-02-07 00:00:00
abstract：:Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.07.018
更新日期：2018-12-01 00:00:00
abstract：:Most functional neuroimaging techniques rely on activation-flow coupling (AFC) to detect changes in regional brain function, but AFC responses may also be altered during pathophysiological conditions such as ischemia. To define the relationship between progressive ischemia and the AFC response, graded levels of cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.024
更新日期：2005-06-14 00:00:00
abstract：:Following lesions of the pyramidal tract in hamsters, retrograde changes were studied in the sensorimotor cortex and in the pyramidal tract axons proximal to the lesion, at survival times ranging from 2 weeks to 14 months. Severe cell shrinkage occurred in layer 5 pyramidal neurons as early as 2 weeks, but there was n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90130-4
更新日期：1975-05-16 00:00:00
abstract：:Antagonism of the alpha receptor sub-type at gamma-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAA receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90222-4
更新日期：1994-07-04 00:00:00
abstract：:A quantitative double blind procedure is described to test the myelinotoxicity of cerebrospinal fluid (SSF) by using optic nerves of Xenopus tadpoles as an in vivo model of a myelinated CNS tract. Only 0.5 ml of unconcentrated CSF is needed for a test and the result is known in 5 days. Groups of 8-10 Xenopus tadpoles ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90500-5
更新日期：1977-01-14 00:00:00
