Abstract：
:During functional spinal neural network activity motoneurons receive massive synaptic excitation and inhibition, and their membrane conductance increases considerably - they are switched to a high-conductance state. High-conductance states can substantially alter response properties of motoneurons. In the present study we investigated how an increase in membrane conductance affects spike frequency adaptation, the gain (i.e., the slope of the frequency-current relationship) and the threshold for action potential generation. We used intracellular recordings from adult turtle motoneurons in spinal cord slices. Membrane conductance was increased pharmacologically by extracellular application of the GABAA receptor agonist muscimol. Our findings suggest that an increase in membrane conductance of about 40-50% increases the magnitude of spike frequency adaptation, but does not change the threshold for action potential generation. Increased conductance causes a subtractive rather than a divisive effect on the initial and the early frequency-current relationships and may have not only a subtractive but also a divisive effect on the steady-state frequency-current relationship.
journal_name
Brain Resjournal_title
Brain researchauthors
Grigonis R,Guzulaitis R,Buisas R,Alaburda Adoi
10.1016/j.brainres.2016.07.030subject
Has Abstractpub_date
2016-10-01 00:00:00pages
110-118issue
Pt Aeissn
0006-8993issn
1872-6240pii
S0006-8993(16)30512-1journal_volume
1648pub_type
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