Abstract：
:Several studies have recently shown that basal and stress-induced secretion of corticosterone may enhance vulnerability to drugs of abuse. In this report, we studied the effects of metyrapone, an inhibitor of the synthesis of corticosterone, on cocaine-induced locomotion and on the relapse of cocaine self-administration. Locomotor response to cocaine was studied because psychomotor effects of drugs have been shown to be related to their reinforcing properties. Self-administration was studied in the relapse phase since blockade of relapse is central to the therapy of addiction. Before these behavioral tests, rats in different experimental groups were injected subcutaneously with either metyrapone (100 mg/kg) or vehicle, twice a day for 8 days. Metyrapone treatment reduced cocaine-induced locomotor activity and relapse of cocaine self-administration, without inducing a nonspecific disruption of motor or food-directed behaviors. Under these experimental conditions, the metyrapone treatment totally blocked stress-induced corticosterone secretion but did not modify basal corticosterone levels. These results confirm the involvement of glucocorticoids in the pathophysiological mechanisms underlying vulnerability to drug abuse, and may have implications for the development of new therapeutic strategies of drug addiction.
journal_name
Brain Resjournal_title
Brain researchauthors
Piazza PV,Marinelli M,Jodogne C,Deroche V,Rougé-Pont F,Maccari S,Le Moal M,Simon Hdoi
10.1016/s0006-8993(09)90034-8subject
Has Abstractpub_date
1994-09-26 00:00:00pages
259-64issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(09)90034-8journal_volume
658pub_type
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