Abnormal localization of iron regulatory protein in Alzheimer's disease.

Abstract:

:A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic lesions with markers of free radical-induced damage and redox-active iron. We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis. Here, we report that while IRP-1 is present at similar levels in both Alzheimer and control brain tissue, IRP-2 shows striking differences and is associated with intraneuronal lesions, including neurofibrillary tangles, senile plaque neurites and neuropil threads. Since IRP-2 colocalizes with redox-active iron, our results suggest that alterations in IRP-2 might be directly linked to impaired iron homeostasis in Alzheimer's disease.

journal_name

Brain Res

journal_title

Brain research

authors

Smith MA,Wehr K,Harris PL,Siedlak SL,Connor JR,Perry G

doi

10.1016/s0006-8993(98)00002-x

subject

Has Abstract

pub_date

1998-03-30 00:00:00

pages

232-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(98)00002-X

journal_volume

788

pub_type

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