Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats.

Abstract:

:In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium relative to controls, particularly after prolonged (90 min) exposure to high potassium. The data suggest that estrogen may help to maintain cholinergic function under conditions where cholinergic afferents to the hippocampal formation and cortex are challenged or impaired.

journal_name

Brain Res

journal_title

Brain research

authors

Gibbs RB,Hashash A,Johnson DA

doi

10.1016/s0006-8993(96)01375-3

subject

Has Abstract

pub_date

1997-02-21 00:00:00

pages

143-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006899396013753

journal_volume

749

pub_type

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