Abstract:
:The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and D-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) but not in the nucleus accumbens or striatum: PFC DOPAC was significantly increased and decreased bilaterally after 24 and 48 h of food deprivation, respectively. Left greater than right hemispheric asymmetries were seen for DOPAC and DOPAC/DA in the control animals. In a separate experiment, 24 h of food deprivation enhanced right rotational behavior, while 48 h significantly increased left rotational behavior. The results are discussed in terms of food deprivation's effects on mesocortical DAergic neurons, previous work on cortical modulation of striatal function and how these effects on rotational behavior may be determined by brain asymmetry.
journal_name
Brain Resjournal_title
Brain researchauthors
Carlson JN,Glick SD,Hinds PA,Baird JLdoi
10.1016/0006-8993(88)90840-2subject
Has Abstractpub_date
1988-06-28 00:00:00pages
373-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90840-2journal_volume
454pub_type
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