Food deprivation alters dopamine utilization in the rat prefrontal cortex and asymmetrically alters amphetamine-induced rotational behavior.

Abstract:

:The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and D-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) but not in the nucleus accumbens or striatum: PFC DOPAC was significantly increased and decreased bilaterally after 24 and 48 h of food deprivation, respectively. Left greater than right hemispheric asymmetries were seen for DOPAC and DOPAC/DA in the control animals. In a separate experiment, 24 h of food deprivation enhanced right rotational behavior, while 48 h significantly increased left rotational behavior. The results are discussed in terms of food deprivation's effects on mesocortical DAergic neurons, previous work on cortical modulation of striatal function and how these effects on rotational behavior may be determined by brain asymmetry.

journal_name

Brain Res

journal_title

Brain research

authors

Carlson JN,Glick SD,Hinds PA,Baird JL

doi

10.1016/0006-8993(88)90840-2

subject

Has Abstract

pub_date

1988-06-28 00:00:00

pages

373-7

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(88)90840-2

journal_volume

454

pub_type

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