Abstract：
:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 28-54% over the 6-h time course. In contrast, insulin hyperphagia was only transiently (2 h) inhibited (27-30%) by either the irreversible mu 1 antagonist, naloxonazine (50 micrograms, i.c.v.) or the selective kappa antagonist, nor-binaltorphamine (NorBNI, 20 micrograms, i.c.v.). The delta-antagonistic actions of [D-Ala2, Leu5, Cys6]-enkephalin (DALCE, 40 micrograms, i.c.v.) failed to affect insulin hyperphagia. These data suggest that the mu 2 opioid receptor subtype modulates insulin hyperphagia.
journal_name
Brain Resjournal_title
Brain researchauthors
Beczkowska IW,Bodnar RJdoi
10.1016/0006-8993(91)90977-4subject
Has Abstractpub_date
1991-05-03 00:00:00pages
315-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90977-4journal_volume
547pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:It has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. The data reviewed here, however, suggest that the oft-stated generalization that normal aging is characterized by disruption of cholinergic input to the hippoca...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(87)90007-5
更新日期：1987-11-01 00:00:00
abstract：:We have applied a technique involving multi-channel linear filtering to the problem of sorting and identifying singly unit neuronal activity in records containing several simultaneously active units. The technique is effective even when the waveforms of two or more nerve impulses are superimposed. We have applied it s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90883-5
更新日期：1975-08-22 00:00:00
abstract：:Retinal and tectal potentials to alternating gratings were recorded in pigeons raised monocularly deprived. Deprived eyes showed consistent myopia and anterior-posterior axis elongation. In addition, vitreal opacities were observed in 70% of the deprived eyes. In pigeons with vitreal opacities, a reduction of retinal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90165-9
更新日期：1985-07-15 00:00:00
abstract：:Brief applications of high glycine concentrations to hippocampal slices have been shown to produce long-lasting changes in synaptic efficacy. In the present study, we show that glycine application transiently and reversibly increases the amplitude and prolongs the duration of synaptic potentials mediated by N-methyl-D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90329-l
更新日期：1993-11-12 00:00:00
abstract：:Neurokinin A and B (NKA and NKB) and neuropeptide K (NPK) were recently isolated from porcine spinal cord and brain, and together with substance P (SP) considerably extend the list of tachykinin-like peptides present in the mammalian nervous system. In order to investigate the distribution of tachykinins in the centra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91514-3
更新日期：1986-12-10 00:00:00
abstract：:Developmental differences (9- to 15-year-olds) in effective connectivity in left hemisphere regions were examined using dynamic causal modeling (DCM) of functional magnetic resonance imaging (fMRI) data. Children completed spelling tasks in the visual and auditory modalities in which they were asked to determine if tw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.080
更新日期：2008-01-16 00:00:00
abstract：:Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.028
更新日期：2009-12-11 00:00:00
abstract：:Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91511-2
更新日期：1985-02-18 00:00:00
abstract：:Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91232-x
更新日期：1982-06-03 00:00:00
abstract：:Intracranial microdialysis was used to measure dopamine (DA) release in the ventrolateral neostriatum of freely moving rats before and after unilateral tactile stimulation was applied to the orofacial region. Several behavioral parameters which have been linked to changes in nigrostriatal DA transmission (scanning, or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90842-j
更新日期：1991-07-12 00:00:00
abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02793-1
更新日期：2000-10-13 00:00:00
abstract：:The present study was undertaken to explore the neuronal mechanisms of hypocretin actions on neurons in the nucleus pontis oralis (NPO), a nucleus which plays a key role in the generation of active (REM) sleep. Specifically, we sought to determine whether excitatory postsynaptic potentials (EPSPs) evoked by stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02566-6
更新日期：2003-06-27 00:00:00
abstract：:Elevations in the plasma levels of glucocorticoids are associated with cognitive impairments that have been ascribed to loss of neurons in the hippocampal formation. However, recent studies have strongly challenged this view. In order to clarify this issue, we have employed for the first time the optical fractionator ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00218-2
更新日期：1998-06-01 00:00:00
abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91311-n
更新日期：1991-04-05 00:00:00
abstract：:5-Hydroxytryptamine (5-HT) has been shown to activate the hypothalamo-pituitary-adrenal axis, possibly by a direct action on hypothalamic CRF synthesis and release. In order to study the mechanisms involved in this effect, foetal hypothalamic cells were cultured and corticotropin-releasing factor-41 (CRF) release was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90826-u
更新日期：1992-03-06 00:00:00
abstract：:We tested the hypothesis that intravenous infusion of human marrow stromal cells (hMSC) with a nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA/NONOate), enhances angiogenesis, neurogenesis and neurological functional recovery after stroke in rats compared to indivi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.080
更新日期：2004-04-16 00:00:00
abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00072-9
更新日期：1998-04-20 00:00:00
abstract：:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02308-9
更新日期：2002-04-05 00:00:00
abstract：:Dendritic architecture and distribution of dendritic protrusions were studied on Golgi-impregnated neurons in the medial preoptic area (MPOA) of infant rats (7 and 20 days old), of animals at puberty (34 days old) and of postpubertal rats (90 days old) using computerized image analysis. The protrusions showed a peak d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90006-4
更新日期：1986-04-01 00:00:00
abstract：:Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.068
更新日期：2011-08-02 00:00:00
abstract：:Dendrites were transected 100 microns from nerve cell somata. The probability of cell survival increased as a function of the extent of proximal segment retraction. The retraction effect is probably the result of increased resistance to calcium and sodium currents at the lesion. It is speculated that limitation of ner...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90526-9
更新日期：1987-11-10 00:00:00
abstract：:The present study examined dopamine-immunoreactive neuronal structures using immunohistochemistry in conjunction with an anti-dopamine antiserum, following injection of l-3,4-dihydroxyphenylalanine (L-DOPA) with or without an inhibitor of monoamine oxidase (Pargyline) in the cat brain. L-DOPA injection made it possibl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.081
更新日期：2007-09-05 00:00:00
abstract：:To determine the mechanisms underlying the depolarization induced by anoxia in brainstem neurons, we studied single neurons in brainstem slices using conventional micro-electrodes and freshly dissociated hypoglossal and vagal cells using patch clamp techniques (whole-cell configuration). Since glutamate concentration ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91067-3
更新日期：1993-10-22 00:00:00
abstract：:The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90015-x
更新日期：1983-12-19 00:00:00
abstract：:The experimental evidence linking glutamate to ischemic neuronal injury is derived from in vitro or in vivo animal stroke models. We, therefore, developed an in vitro preparation to determine whether glutamate contributes to early neuronal swelling in oxygen and glucose deprived (OGD) human neocortical slices. In orde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01286-9
更新日期：1998-01-26 00:00:00
abstract：:Rats received 1-stage bilateral and sequential unilateral (serial) lesions of the posterior hypothalamus and were tested for the ability to regulate body temperature after a lengthy recovery period. The groups with lesion differed from the sham-operated groups in the cold, although not under ambient or warm conditions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90309-7
更新日期：1981-08-31 00:00:00
abstract：:Membrane properties of rat magnocellular neuroendocrine cells (MNCs) were examined during intracellular recordings in vivo. Current-clamp experiments revealed sustained outward rectification positive to -55 mV and transient outward rectification of depolarizing responses elicited from negative holding potentials. Trai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90535-4
更新日期：1991-02-01 00:00:00
abstract：:Structural equation modeling (SEM) and fMRI were used to test whether changes in the regional activity are accompanied by changes in the inter-regional connectivity as motor practice progresses. Ten healthy subjects were trained to perform finger movement task daily for 4 weeks. Three sessions of fMRI images were acqu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.073
更新日期：2010-03-08 00:00:00
abstract：:Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147049
更新日期：2020-11-15 00:00:00
abstract：:Glial-cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN) and persephin (PSPN), known as the GDNF family ligands (GFLs), influence the development, survival and differentiation of cultured dopaminergic neurons from ventral mesencephalon (VM). Detailed knowledge about the effects of GFLs on o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.056
更新日期：2006-01-19 00:00:00
