Abstract：
:The present study examined dopamine-immunoreactive neuronal structures using immunohistochemistry in conjunction with an anti-dopamine antiserum, following injection of l-3,4-dihydroxyphenylalanine (L-DOPA) with or without an inhibitor of monoamine oxidase (Pargyline) in the cat brain. L-DOPA injection made it possible to detect dopamine immunoreactivity in presumptive serotonergic and noradrenergic cell bodies and axons. Weak to moderate dopamine immunoreactivity was observed in non-aminergic cells (possibly so-called "D" cells containing aromatic L-amino acid decarboxylase (AADC)) in several hypothalamic, midbrain, pontine and medullary nuclei. Intense dopamine immunoreactivity became visible in a large number of cells and axons (possibly containing AADC) with wide distribution in the brain following administration of L-DOPA with Pargyline. AADC is most likely active in cells and axons that take up L-DOPA, where it decarboxylates the L-DOPA to dopamine. However, newly synthesized dopamine in such cells is rapidly oxidized by monoamine oxidase.
journal_name
Brain Resjournal_title
Brain researchauthors
Kitahama K,Geffard M,Araneda S,Arai R,Ogawa K,Nagatsu I,Pequignot JMdoi
10.1016/j.brainres.2007.05.081subject
Has Abstractpub_date
2007-09-05 00:00:00pages
56-70eissn
0006-8993issn
1872-6240pii
S0006-8993(07)01345-5journal_volume
1167pub_type
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