Abstract：
:Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and P-fracture faces and the cross-fractured cytoplasm of these astrocytes (termed 'perinodal astrocytes') were examined. The cytoplasm of perinodal astrocytes contains 10-nm filaments. The P-faces of perinodal astrocytic membranes are characterized by orthogonal arrays of intramembranous particles ('assemblies'), with a center-to-center periodicity of approximately equal to 6 nm. Complementary orthogonally arranged pits are observed on the E-faces of the astrocytic membranes. The density of these arrays in perinodal astrocytic membranes is similar to that in parenchymal astrocytic membranes, but is substantially lower than that at pericapillary astrocytic membranes. In addition, gap junctions are present between astrocytes, and between astrocytes and paranodal oligodendroglial layers. These findings indicate that astrocytic processes comprise an important structural component of central nodes of Ranvier, and provide a morphological basis for a possible astrocytic role in nodal function.
journal_name
Brain Resjournal_title
Brain researchauthors
Waxman SG,Black JAdoi
10.1016/0006-8993(84)90919-3subject
Has Abstractpub_date
1984-08-06 00:00:00pages
77-87issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90919-3journal_volume
308pub_type
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