Abstract:
:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hippocampal pyramidal neurons. The pattern of inhibition mirrored the binding kinetics of insulin in the hippocampus. Two related peptides, proinsulin and desoctapeptide insulin, had neuronal effects consistent with their binding to insulin receptors in the brain. Proinsulin was effective in doses 30-fold greater than insulin, whereas desoctapeptide insulin had little or no effect. These observations indicate that the inhibitory effect of insulin in this tissue may be insulin receptor-mediated and support a previously suggested functional role of insulin in the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Palovcik RA,Phillips MI,Kappy MS,Raizada MKdoi
10.1016/0006-8993(84)91028-xsubject
Has Abstractpub_date
1984-08-20 00:00:00pages
187-91issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)91028-Xjournal_volume
309pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90481-1
更新日期:1987-11-03 00:00:00
abstract::Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.025
更新日期:2006-09-07 00:00:00
abstract::Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00304-9
更新日期:1995-05-29 00:00:00
abstract::The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00613-6
更新日期:1997-09-05 00:00:00
abstract::The blood-brain barrier (BBB) prevents many drugs from entering the brain. Yet, conventional methods that open the BBB are technically demanding, poorly reversible, and can be associated with long-term adverse effects. In comparison, carbogen, which is introduced nearly a century ago as a treatment for psychiatric dis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146320
更新日期:2019-10-01 00:00:00
abstract::Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.014
更新日期:2011-05-10 00:00:00
abstract::Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90826-8
更新日期:1988-06-28 00:00:00
abstract::The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90731-n
更新日期:1992-05-29 00:00:00
abstract::Neurotensin (NT) is a neuropeptide neurotransmitter in the central nervous system. It has been implicated in the therapeutic and in the adverse effects of neuroleptics. Activity of NT in brain can only be shown by direct injection of the peptide into that organ. However, we have developed a novel analog of NT(8-13), N...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02363-x
更新日期:2000-02-21 00:00:00
abstract::Tumor suppressor p53 has recently been reported to have numerous functions independent of tumorigenesis, including neuronal survival during ischemia. The mammalian target of rapamycin (mTOR) signaling pathway plays a central role in the regulation of metabolism, cell growth, development, and cell survival. Our recent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.009
更新日期:2015-04-24 00:00:00
abstract::Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90875-1
更新日期:1981-11-16 00:00:00
abstract::Nineteen convergent neurones, 19 'non-noxious only' neurones and 13 'proprioceptive' neurones all with peripheral excitatory receptive fields on the ipsilateral hindpaw, were recorded in the lumbar dorsal horn of non-spinalized, anaesthetized rats. These neurones were all excited by the electrophoretic application of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91147-8
更新日期:1984-04-23 00:00:00
abstract::Somatosensory information has been thought to ascend from the spinal cord to limbic areas of the telencephalon through indirect, multisynaptic pathways. We now report that injections of Fluoro-gold into either the nucleus accumbens or the septal nuclei labeled hundreds of neurons in the spinal cord. These and our rece...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90981-5
更新日期:1989-09-11 00:00:00
abstract::Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a v...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.051
更新日期:2004-08-20 00:00:00
abstract::In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01081-6
更新日期:1999-01-02 00:00:00
abstract::17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2012.12.015
更新日期:2013-06-13 00:00:00
abstract::Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03209-7
更新日期:2001-12-27 00:00:00
abstract::Based on pharmacological evidence that inhibitory amino acids mediate vaginocervical mechano-stimulation produced analgesia (VSPA), we hypothesized that inhibitory amino acids would be released endogenously in the spinal cord in response to vaginocervical mechano-stimulation (VS). This hypothesis was tested by HPLC an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90117-6
更新日期:1993-09-10 00:00:00
abstract::Developmental differences (9- to 15-year-olds) in effective connectivity in left hemisphere regions were examined using dynamic causal modeling (DCM) of functional magnetic resonance imaging (fMRI) data. Children completed spelling tasks in the visual and auditory modalities in which they were asked to determine if tw...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.080
更新日期:2008-01-16 00:00:00
abstract::The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP. L-thr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90805-6
更新日期:1991-12-20 00:00:00
abstract::The effects of glucagon like peptide-1 (GLP-1) on reflex swallowing were examined using anaesthetized rats. GLP-1 was injected into the dorsal vagal complex (DVC) using glass micropipettes. Swallowing was induced by repeated electrical stimulation of the central cut end of the superior laryngeal nerve (SLN) and was id...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.07.004
更新日期:2017-09-15 00:00:00
abstract::We have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) receptor in the neuromuscular system as a result of voluntary physical activity. We assessed changes in the mRNAs and proteins for NT-3 and TrkC in the lumbar spinal cord and associated soleus muscle following 3 and 7...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03258-x
更新日期:2003-10-10 00:00:00
abstract::In behaving cats, a cholinergic agonist, carbachol, or Ringer's solution were infused into the pontine reticular formation (PRF). Extracellular microelectrode recordings were obtained from single neurons located 1-4 mm from the infusion site. Sleep polygraphic variables were also recorded. Carbachol microinfusions int...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90137-x
更新日期:1986-10-29 00:00:00
abstract::High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90366-5
更新日期:1986-04-23 00:00:00
abstract::In monkeys (Macaca fuscata and mulatta), horseradish peroxidase (HRP) was injected in the cerebral cortices, areas 4 (medial and lateral parts), 5, 6 and 9 (a part just rostral to area 6), in which stimulation of cerebellar nuclei was known to elicit superficial or deep thalamocortical responses. Retrogradely labelled...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90698-4
更新日期:1983-09-12 00:00:00
abstract::The involvement of terminal sprouts in neurotransmitter release by in vivo botulinum type-A toxin poisoned motor endings was investigated 15 to 40 days after a single injection of the toxin onto the levator auris longus muscle of the mouse. Enhanced quantal acetylcholine release was induced by alpha-latrotoxin or La3+...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00475-2
更新日期:1998-06-29 00:00:00
abstract::Cerebral vascular density is correlated with metabolic demands, which increase in highly active brain areas. External inputs are an essential requirement in the modeling of the visual cortex. Experience-mediated development is very active during the first postnatal month, when congruous blood supply is needed. We stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02361-6
更新日期:2000-02-07 00:00:00
abstract::Binding sites for iodinated endothelin (ET)-2, ET-3 and vasoactive intestinal contractor (VIC) were visualised in the adult rat brain using quantitative autoradiography and have a similar anatomical distribution to that of ET-1 and sarafotoxin S6b. Highest densities of binding sites for all 5 labelled peptides were pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90201-6
更新日期:1991-07-19 00:00:00
abstract::A role for glutamatergic signaling in the nucleus accumbens (NA) in both the expression and extinction of cocaine seeking has been suggested. The effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of GluR1 and NMDAR1 glutamate receptor subunits in the NA shell a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.047
更新日期:2009-04-24 00:00:00
abstract::The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91147-3
更新日期:1985-09-09 00:00:00