Abstract：
:The discovery of glucagon biosynthesis and receptors within mammalian brain has led one to suspect a neurotransmitter role for glucagon. In order to address this hypothesis in birds, we investigated the existence of glucagon receptors in duck brain by radioligand binding on fresh tissue sections and radioautography. Specific high-affinity [125I]glucagon binding sites similar to those in the liver were demonstrated in the avian brain. Mapping of these putative glucagon receptors revealed a discrete distributional pattern. Most of the [125I]glucagon binding capacity in duck brain is concentrated within the telencephalon, mainly in components of motor and limbic systems. Specific labeling densities were associated with avian equivalents of the mammalian pyramidal system (hyperstriatum accessorium; archistriatum intermedium and tractus occipitomesencephalicus) and extrapyramidal system (paleostriatum augmentatum, paleostriatum primitivum and lobus parolfactorius), as well as several limbic structures (hippocampal formation, nucleus taeniae and the caudal part of the archistriatum). Few glucagon-reactive foci were detected in the diencephalon (the nucleus dorsomedialis of hypothalamus, the two circumventricular organs, organum vasculosum of the lamina terminalis and median eminence and the nucleus habenularis medialis). These findings suggest that glucagon might be involved in the central control of somatic motricity and basic behaviors and point therefore to glucagon as a new neuroactive messenger in avian brain. The extensive difference between the distribution of glucagon binding sites observed in duck brain and that previously reported in rat brain suggests that glucagon does not subserve the same physiological role(s) in avian and mammalian brains.
journal_name
Brain Resjournal_title
Brain researchauthors
Montaron A,Moyse E,Barré Hdoi
10.1016/0006-8993(94)90469-3subject
Has Abstractpub_date
1994-11-07 00:00:00pages
121-30issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)90469-3journal_volume
663pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00990-0
更新日期：1996-10-28 00:00:00
abstract：:High cell density, with attendant aggregation, selectively increases expression of substance P (SP) and choline acetyltransferase (ChAT) in virtually pure neonatal sympathetic neuronal cultures. To investigate the specific role of cell contact in selective transmitter expression, SP content and ChAT activity were exam...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80202-5
更新日期：1986-12-01 00:00:00
abstract：:The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91368-3
更新日期：1993-03-05 00:00:00
abstract：:Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.032
更新日期：2012-11-27 00:00:00
abstract：:An in vitro preparation was used to determine if rapidly transported radiolabeled protein which is isolated with the myelin fraction of frog sciatic nerves is similar to rapidly transported radiolabeled protein released from sciatic nerves. Sciatic nerves along with their eighth and ninth dorsal root ganglia were plac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90525-x
更新日期：1982-05-13 00:00:00
abstract：:In the course of pulse-label studies on the axonal transport of the small, basic, actin-binding proteins--actin depolymerizing factor, cofilin and profilin--in chicken motor neurones, we observed a heavily labelled protein of M(r) 18 kDa and pI 8.2 on fluorographs of two-dimensional polyacrylamide gels. On the basis o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00766-x
更新日期：1997-10-17 00:00:00
abstract：:The content of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) was analysed in 71 human spinal cords obtained post-mortem. The highest content of 5-HT, 5-HIAA and NE was found in the lumbar enlargement of the spinal cord. 5-HT and 5-HIAA content increased from fetal to adult spinal cord w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91613-7
更新日期：1988-03-08 00:00:00
abstract：:Neuropeptide Y (NPY) blocks the effect of light on the mammalian circadian clock during the subjective night. The present study explores the role of the NPY Y1 receptor in this interaction. The effect of NPY when co-applied with NMDA, a glutamate agonist that can mimic the effect of light, was examined in NPY Y1-/- mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.037
更新日期：2004-10-08 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：:We report the localization of angiotensin-converting enzyme (kininase II, EC 3.4.15.1) in discrete nuclei and areas of the rat brain by a quantitative autoradiographic technique using image processing coupled to computerized microdensitometry, after incubation of brain sections with the specific converting enzyme inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90746-8
更新日期：1986-06-11 00:00:00
abstract：:The effects of midazolam, one of the most popular benzodiazepines, on synaptic transmissions were compared with intracellular recordings between CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. First, we studied the effects of midazolam on orthodromically evoked spikes,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00920-7
更新日期：1997-10-31 00:00:00
abstract：:The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults. Partial nerve injury elicited neuropathic pain is accompanied by increased phosphoryl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03348-1
更新日期：2003-10-24 00:00:00
abstract：:Transport of fragmented DNA in apical dendrites of the CA1 pyramidal neurons of gerbil hippocampus is observed in the apoptotic process following transient forebrain ischemia. The time-course of specific DNA fragmentation was examined after the ischemic insult by in situ nick-end-labeling method and fluorescence detec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00753-7
更新日期：1998-09-28 00:00:00
abstract：:An endogenous opioid peptide, [Met5]-enkephalin, termed opioid growth factor (OGF) is a tonically active, autocrine-produced inhibitory molecule related to developing, neoplastic, renewing and healing tissues. The present investigation was designed to examine the role of OGF on corneal epithelial wound closure in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00610-6
更新日期：1998-08-24 00:00:00
abstract：:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90284-5
更新日期：1981-08-24 00:00:00
abstract：:N-Acetylated-alpha-linked acidic dipeptidase (NAALADase) hydrolyzes N-acetyl-aspartyl-glutamate (NAAG) to liberate N-acetyl-aspartate and glutamate. NAAG is a putative neurotransmitter and acts as a mixed agonist/antagonist on N-methyl-D-aspartate (NMDA) receptors and acts as an agonist on the metabotropic glutamate r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02650-6
更新日期：2001-08-03 00:00:00
abstract：:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00026-m
更新日期：1995-04-03 00:00:00
abstract：:Decreasing transsynaptic activity through surgical adrenal denervation or by medullary explantation, increases Leu-enkephalin immunoreactivity (Leu-Enk) and preproenkephalin mRNA (prepro-EK). Membrane depolarization prevents this rise. To determine whether depolarizing effects are mediated by intracellular movement of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91407-2
更新日期：1988-02-16 00:00:00
abstract：:Experiments were performed which demonstrate that low power, pulsed microwave exposure induces a significant increase in local cerebral blood flow within the brain of the conscious rat. Previous studies purporting to examine changes in brain vascular permeability induced by microwave radiation must be re-evaluated in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90668-5
更新日期：1981-01-05 00:00:00
abstract：:Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.062
更新日期：2007-10-12 00:00:00
abstract：:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90678-1
更新日期：1989-04-17 00:00:00
abstract：:Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90663-8
更新日期：1985-06-17 00:00:00
abstract：:Glutamate induced responses in the surface membrane of Xenopus oocyte by injection with mRNA from crustacea and insect muscle. Glutamate (10(-5) to 10(-4) M) elicited smooth current responses which resembled those induced by kainate. This smooth current reversed direction at about 0 mV and was blocked by a spider toxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90048-9
更新日期：1987-12-01 00:00:00
abstract：:3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death tr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00447-2
更新日期：1997-06-20 00:00:00
abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01488-8
更新日期：1996-03-25 00:00:00
abstract：:A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91348-9
更新日期：1984-05-21 00:00:00
abstract：:Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91312-3
更新日期：1992-10-16 00:00:00
abstract：:The effects of 0.1 to 500 mM ethanol on NMDA-activated currents were studied in primary cultures of mouse cortical and hippocampal neurons. In whole-cell recordings the IC50S for inhibition of NMDA-activated currents by ethanol were 129 mM +/- 20 mM in hippocampal neurons and 126 +/- 18 mM in cortical neurons. In sing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00780-9
更新日期：1996-11-04 00:00:00
abstract：:The main purpose of the present study was to determine whether specific lymphokines may be neurotrophic, by testing their effects on the survival of hippocampal neuronal cultures. Previous studies have shown that a variety of interleukins may be neurotrophic or neurotoxic, depending upon the culture conditions, as wel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90400-h
更新日期：1993-01-08 00:00:00
