Abstract:
:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous large varicosities reminiscent of terminal boutons, which closely surrounded GPi cell bodies and primary dendrites. Conversely, PHA-L injections in the GPi of squirrel monkeys produced anterograde fiber labeling in the GPe. However, in contrast to fibers in GPi, those in GPe did not make prominent pericellular contacts. Instead, they displayed a rather linear course, had long intervaricose segments, and appeared to contact several GPe neurons along their course by close appositions on cell bodies and primary dendrites. These results suggest the existence of a reciprocal connection between the two pallidal segments, which may play a crucial role in the functional organization of the basal ganglia in primates.
journal_name
Brain Resjournal_title
Brain researchauthors
Hazrati LN,Parent A,Mitchell S,Haber SNdoi
10.1016/0006-8993(90)91813-vsubject
Has Abstractpub_date
1990-11-12 00:00:00pages
171-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91813-Vjournal_volume
533pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::At present severe damage to hair cells and sensory neurons in the inner ear results in non-treatable auditory disorders. Cell implantation is a potential treatment for various neurological disorders and has already been used in clinical practice. In the inner ear, delivery of therapeutic substances including neurotrop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.078
更新日期:2011-03-04 00:00:00
abstract::High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(86)90016-1
更新日期:1986-07-01 00:00:00
abstract::The neurosteroid allopregnanolone is a potent and efficacious modulator of gamma-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 micrograms/5 microliters) on basal and stress-induced release of acetylcholine were investigated in various regions o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01478-0
更新日期:1996-02-26 00:00:00
abstract::The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...
journal_title:Brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0006-8993(96)01268-1
更新日期:1997-01-30 00:00:00
abstract::Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02086-8
更新日期:2001-04-06 00:00:00
abstract::Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.10.062
更新日期:2015-01-21 00:00:00
abstract::Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90064-i
更新日期:1990-06-11 00:00:00
abstract::The behavioral and EEG effects of rat and ovine corticotropin releasing factor (r- and o-CRF) were compared. Both peptides were injected intracerebroventricularly into rats through chronically implanted cannulae. At the doses of 0.1 and 1 microgram both peptides activated the EEG and stimulated motor activity. At the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90413-6
更新日期:1987-04-07 00:00:00
abstract::Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90085-8
更新日期:1983-03-01 00:00:00
abstract::Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.05.008
更新日期:2005-06-28 00:00:00
abstract::We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.03.021
更新日期:2019-04-15 00:00:00
abstract::Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91444-6
更新日期:1991-12-13 00:00:00
abstract::Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03749-6
更新日期:2003-01-10 00:00:00
abstract::We have examined the afferent and efferent projections between the claustrum and visual cortex in the Long-Evans rat using anterograde and retrograde axonal transport techniques. Injections of either wheat germ agglutinin/horseradish peroxidase (WGA/HRP) or Fast Blue were made into each of the main visual regions (17,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90524-4
更新日期:1985-03-11 00:00:00
abstract::Endogenous long-duration burst-organizing potentials (driver potentials, DPs) generated by neurons in the lobster cardiac ganglion play a critical role in the ability of the system to generate rhythmic bursts of nerve impulses. The DPs are normally terminated by a voltage-dependent potassium current, but when this is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90854-g
更新日期:1993-04-23 00:00:00
abstract::Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90081-9
更新日期:1988-07-12 00:00:00
abstract::In the electrophysiologic test of the hindlimb withdrawal reflex where the long latency component is found to be dependent on noradrenaline (NA), implants of fetal NA tissue in lesioned animals result in a recovery of NA dependent function proportional to the number of catecholamine fluorescent cells in the implants. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90396-s
更新日期:1990-02-05 00:00:00
abstract::The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90107-x
更新日期:1984-08-01 00:00:00
abstract::Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the CA3 region resulted in a series of population cell bursts in CA3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91618-0
更新日期:1987-12-01 00:00:00
abstract::We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.068
更新日期:2009-12-01 00:00:00
abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.014
更新日期:2009-08-11 00:00:00
abstract::Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04151-3
更新日期:2003-03-07 00:00:00
abstract::Active substance P binding sites were solubilized from rat brain membranes by treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. About 50% of the binding activity in membrane-bound binding sites was recovered in the solubilized fraction after centrifugation at 105,000 g for 1 h. [3H]Substance P absorbed exte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91122-4
更新日期:1986-04-02 00:00:00
abstract::Parkinson's disease (PD) is caused by oxidative stress, and erythropoietin (EPO) reduces oxidative stress in the brain. However, EPO cannot be developed as a treatment for PD, because EPO does not cross the blood-brain barrier (BBB). A brain penetrating form of human EPO has been developed wherein EPO is fused to a ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.061
更新日期:2011-03-25 00:00:00
abstract::Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90787-a
更新日期:1992-02-28 00:00:00
abstract::The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90097-9
更新日期:1982-05-01 00:00:00
abstract::This study assessed the contribution of K+ conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from rats. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in sta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00124-2
更新日期:1996-04-29 00:00:00
abstract::Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02929-2
更新日期:2000-11-17 00:00:00
abstract::Maternal cocaine abuse has several deleterious effects in the newborn, including perinatal asphyxia, hypoxia, and hypercapnia. We hypothesized that chronic cocaine exposure during development may alter cerebral blood flow (CBF) regulation. We studied 16 neonatal rabbits that had received cocaine (20 mg/kg, i.p. b.i.d....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00178-9
更新日期:1997-04-25 00:00:00
abstract::Catecholamine-containing fibers have been examined in the cerebella of normal and hypocerebellar mutant mice using Falck-Hillarp and glyoxylic acid histofluorescence techniques. The amounts of norepinephrine and dopamine were also determined chemically in the same mutants. Green fluorescent fibers in cerebella of norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90349-2
更新日期:1975-08-08 00:00:00