Potassium channel blockade does not alter the modulatory effects of dopamine in neostriatal slices.

abstract：:This study has examined the retinal synapses of the cat superior colliculus using electron microscope autoradiography and morphometric techniques. The depth of each retinal synapse was measured using a computer-based EM plotter. The area, perimeter, and synapse contact density of selected synapses were calculated usin...

journal_title：Brain research

authors： Mize RR

更新日期：1983-06-20 00:00:00

abstract：:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region...

journal_title：Brain research

authors： Sugimoto K,Abe K,Lee TH,Sakurai E,Yanai K,Kogure K,Itoyama Y,Watanabe T

更新日期：1994-12-15 00:00:00

abstract：:The actions of dopamine are mediated by 5 or more receptor subtypes, any of which may be coupled by G-proteins to adenylate cyclase (D1-family: stimulatory, D2-family: inhibitory or no action). Postnatal ocular growth in the chick is a vision-dependent mechanism which involves D2-type receptors in either the retina or...

journal_title：Brain research

authors： Rohrer B,Stell WK

更新日期：1995-10-16 00:00:00

abstract：:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...

journal_title：Brain research

authors： Woolf NJ,Zinnerman MD,Johnson GV

更新日期：1999-03-06 00:00:00

abstract：:Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...

journal_title：Brain research

authors： Takano M,Horie M,Yayama K,Okamoto H

更新日期：2003-07-18 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...

journal_title：Brain research

authors： Zhang X,Lee SJ,Young KZ,Josephson DA,Geschwind MD,Wang MM

更新日期：2014-10-02 00:00:00

abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...

journal_title：Brain research

authors： Courchesne E,Campbell K,Solso S

更新日期：2011-03-22 00:00:00

abstract：:To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolite tele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast ...

journal_title：Brain research

authors： Hough LB,Khandelwal JK,Goldschmidt RC,Diomande M,Glick SD

更新日期：1984-01-30 00:00:00

abstract：:In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium re...

journal_title：Brain research

authors： Gibbs RB,Hashash A,Johnson DA

更新日期：1997-02-21 00:00:00

abstract：:Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...

journal_title：Brain research

authors： Altenau LL,Agranoff BW

更新日期：1979-01-26 00:00:00

abstract：:We report here the results of an autoradiographic analysis of the postnatal development of the hippocampal glucocorticoid receptor system in the rat brain. Quantitative analysis of the autoradiograms revealed a varied pattern of gradual development towards adult receptor concentrations during the second week of life. ...

journal_title：Brain research

authors： Meaney MJ,Sapolsky RM,McEwen BS

更新日期：1985-02-01 00:00:00

abstract：:The contribution of the pedunculopontine nucleus to exploratory locomotion was investigated in rats. Locomotor activity recorded in a standard open-field apparatus was increased more than two-fold when wooden panels were inserted. This novelty-elicited locomotion was reduced significantly when procaine was injected bi...

journal_title：Brain research

authors： Mogenson GJ,Wu M,Tsai CT

更新日期：1989-04-24 00:00:00

abstract：:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...

journal_title：Brain research

authors： Owashi T,Iritani S,Niizato K,Ikeda K,Kamijima K

更新日期：2004-06-04 00:00:00

abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...

journal_title：Brain research

authors： Kuo MC,Dringenberg HC

更新日期：2012-12-07 00:00:00

abstract：:Sustained neuroinflammation contributes to the pathogenesis of postoperative cognitive dysfunction. Dexmedetomidine, a selective α-2 adrenergic receptor agonist, exhibits a protective role in the brain. This study investigated whether dexmedetomidine pretreatment attenuates neuroinflammation induced by tibial fracture...

journal_title：Brain research

authors： Zhu YJ,Peng K,Meng XW,Ji FH

更新日期：2016-08-01 00:00:00

abstract：:Cognitive impairment is a prevalent non-motor feature of Parkinson's disease (PD) which can present even in early stages of the disease. Impairments in executive processing and working memory (WM) are common and have been attributed, in part, to abnormalities within the dorsolateral prefrontal cortex (DLPFC) and broad...

journal_title：Brain research

authors： Hill AT,McModie S,Fung W,Hoy KE,Chung SW,Bertram KL

更新日期：2020-01-01 00:00:00

abstract：:Changes in the astrocytic cytoskeleton were examined in amygdala kindled rats using immunocytochemical techniques. One week following kindling, there was a dramatic increase in immunoreactivity to glial fibrillary acidic protein and vimentin in astrocytes throughout amygdala, pyriform cortex and hippocampus bilaterall...

journal_title：Brain research

authors： Khurgel M,Racine RJ,Ivy GO

更新日期：1992-10-02 00:00:00

abstract：:To investigate to what extent the loss of cholinergic projections to the neocortex results in functional impairment in the target areas, local rates of cerebral glucose utilization were measured following excitotoxin lesions of the nucleus basalis magnocellularis (NBM) in the rat. Both unilateral and bilateral lesions...

journal_title：Brain research

authors： Orzi F,Diana G,Casamenti F,Palombo E,Fieschi C

更新日期：1988-10-11 00:00:00

abstract：:The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...

journal_title：Brain research

authors： Fukuda S,Taga K,Tsukui A,Nishimura N,Kumagai Y,Shimoji K

更新日期：1989-09-04 00:00:00

abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...

journal_title：Brain research

authors： Zhang B,Yang X,Gao X

更新日期：2010-03-12 00:00:00

abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...

journal_title：Brain research

authors： Kubo KY,Iwaku F,Watanabe K,Fujita M,Onozuka M

更新日期：2005-09-28 00:00:00

abstract：:Electrical stimulation of the retina evokes at the optic tract level rhythmic bursts of activity whose temporal structure is predictable from the polarity of the stimulation and the receptive field type. The reaction of lateral geniculate units to this input was studied in fast and slow relay cells as well as in inter...

journal_title：Brain research

authors： Molotchnikoff S,Lachapelle P

更新日期：1978-08-18 00:00:00

abstract：:Auditory working memory (WM) is the cognitive faculty that allows us to actively hold and manipulate sounds in mind over short periods of time. We develop here a particular perspective on WM for non-verbal, auditory objects as well as for time based on the consideration of possible parallels to visual WM. In vision, t...

journal_title：Brain research

authors： Joseph S,Teki S,Kumar S,Husain M,Griffiths TD

更新日期：2016-06-01 00:00:00

abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...

journal_title：Brain research

authors： Alonso G,Assenmacher I

更新日期：1979-07-13 00:00:00

abstract：:Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...

journal_title：Brain research

authors： Ling GY,Cao WH,Onodera M,Ju KH,Kurihara H,Kurihara Y,Yazaki Y,Kumada M,Fukuda Y,Kuwaki T

更新日期：1998-10-19 00:00:00

abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...

journal_title：Brain research

authors： Reith CA,Sillar KT

更新日期：1997-10-03 00:00:00

abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...

journal_title：Brain research

authors： Wolf DH,Nestler EJ,Russell DS

更新日期：2007-07-02 00:00:00

abstract：:The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...

journal_title：Brain research

authors： Rybnikova E,Sitnik N,Gluschenko T,Tjulkova E,Samoilov MO

更新日期：2006-05-17 00:00:00

abstract：:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines woul...

journal_title：Brain research

authors： Larson J,Lynch G

更新日期：1991-01-11 00:00:00

abstract：:Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...

journal_title：Brain research

authors： Jacquin MF,Rhoades RW

更新日期：1983-06-13 00:00:00