Abstract：
:To investigate to what extent the loss of cholinergic projections to the neocortex results in functional impairment in the target areas, local rates of cerebral glucose utilization were measured following excitotoxin lesions of the nucleus basalis magnocellularis (NBM) in the rat. Both unilateral and bilateral lesions of NBM resulted in reversible depression of cerebral metabolism. The effects of unilateral lesions were limited to the cortical areas which receive most of the cholinergic projections from NBM. The metabolic defect produced by bilateral lesions was spread to the whole brain. Within 4 months, however, normal metabolic values coexisted with marked changes of the presynaptic cholinergic markers and impairment of conditioned behavior.
journal_name
Brain Resjournal_title
Brain researchauthors
Orzi F,Diana G,Casamenti F,Palombo E,Fieschi Cdoi
10.1016/0006-8993(88)90590-2subject
Has Abstractpub_date
1988-10-11 00:00:00pages
99-103issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90590-2journal_volume
462pub_type
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