Abstract：
:Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a number of aversive paradigms. Fast rats entered and spent more time in the open arms and spent less time in the closed arms of the elevated plus-maze (EPM) compared to Slow animals. Fast rats had higher conditioned suppression ratios across testing days, defecated less often during conditioning, and successfully disinhibited suppression during extinction in the conditioned emotional response (CER) paradigm compared to Slow-kindlers. In order to pursue these differences in emotional reactivity between the strains and differentiate negative affect from motivational, learning, and impulsive explanations, a separate group of animals were assessed in the light-enhanced acoustic startle chamber, a test of anxiety. When initially exposed to a bright-light, Slow rats significantly increased their startle response while this was not observed in the Fast strain. In combination with previous research on these strains, the present data tentatively suggest that Fast and Slow animals utilize different neural systems in tests of fear and anxiety which may have been co-selected with the direct selection of amygdala-kindling susceptibility.
journal_name
Brain Resjournal_title
Brain researchauthors
Runke D,McIntyre DCdoi
10.1016/j.brainres.2008.08.090subject
Has Abstractpub_date
2008-11-13 00:00:00pages
143-52eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02196-3journal_volume
1240pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Seasonally breeding animals undergo numerous physiological changes in response to changes in the length of the photoperiod. In most warm-weather breeding rodents, these changes result in reproductive quiescence during short photoperiods. It has been hypothesized that this change is mediated by changes in the activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.083
更新日期：2007-11-14 00:00:00
abstract：:At a physiologically relevant concentration (1.25 microM), aluminum had an activating effect on oligodendrocyte cell cultures, similar to that previously reported for other cell types. G protein-linked signal transduction was stimulated as indicated by enhanced production of IP3, and protein synthesis was increased. A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02597-0
更新日期：2002-06-21 00:00:00
abstract：:Immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. This innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arisi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90896-1
更新日期：1987-11-24 00:00:00
abstract：:The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.098
更新日期：2009-12-08 00:00:00
abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.014
更新日期：2003-11-21 00:00:00
abstract：:The interrelationships between axonal conduction velocity, tetanic tension, twitch contraction time and rate of force development during a tetanus have been studied in 126 motor units from 12 cat medial gastrocnemius muscles. While the range of axonal conduction velocities for slow- (contraction time greater than 45 m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90542-9
更新日期：1975-06-27 00:00:00
abstract：:The distribution and subcellular localization of AH9 antigen, recognized by a monoclonal antibody AH9, were examined in rat brain. Highest expression was observed in the lamina lucidum of the dentate gyrus of the rat hippocampus. Synaptic subfields of other limbic areas also expressed AH9 antigen at a substantial leve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01344-x
更新日期：1996-05-06 00:00:00
abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90426-1
更新日期：1981-12-28 00:00:00
abstract：:Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(84)90022-5
更新日期：1984-05-01 00:00:00
abstract：:The immunohistochemical distribution of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta isoforms in the rat forebrain was examined by using monoclonal antibodies specific to each isoform. The present study confirmed that alpha and beta immunoreactivities are localized only in neuronal elemen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90877-x
更新日期：1994-10-03 00:00:00
abstract：:Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90179-0
更新日期：1989-04-03 00:00:00
abstract：:Testosterone's (T) aggression-enhancing effects may be mediated in part by its 5alpha-reduced, 3-hydroxysteroid dehydrogenized metabolite 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). To test this hypothesis, in Expt. 1 gonadectomized (gdx) C21 mice were administered T, 3alpha-diol, or vehicle and were observed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03076-7
更新日期：2002-09-06 00:00:00
abstract：:Previous studies have shown that microinjection of morphine into the prefrontal ventrolateral orbital cortex (VLO) produces antinociception. The current study examined whether gamma-aminobutyric acid (GABA) containing neurons in the VLO were involved in this antinociception. Under light anesthesia, the GABA(A) recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.067
更新日期：2006-02-16 00:00:00
abstract：:We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90718-o
更新日期：1992-05-29 00:00:00
abstract：:Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90290-9
更新日期：1988-08-30 00:00:00
abstract：:The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.11.062
更新日期：2012-01-30 00:00:00
abstract：:In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02328-3
更新日期：2000-06-23 00:00:00
abstract：:Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91265-2
更新日期：1980-01-06 00:00:00
abstract：:The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. While about 90% of neurons survived 2 h after exposure to ionomycin, the surviving neurons had decreased by about 30 to 40% at 16 h. Both RNA and protein synthesis inhibitors blocked this neurotoxicity....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90317-4
更新日期：1994-07-25 00:00:00
abstract：:This study was performed to investigate the mechanism how amantadine increases the extracellular dopamine (DA) levels in the striatum in vivo. Local application of amantadine (1 mM, 40 min) to the striatum through the dialysis membrane significantly increased the extracellular DA levels. Coadministration of nomifensin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90821-4
更新日期：1994-10-31 00:00:00
abstract：:Synaptic activation of the neurosecretory cells within the glandular lobe of the corpus cardiacum of locusts results in the release of bioassayable adipokinetic hormones and an elevation in cAMP. The effectiveness of several putative aminergic neurotransmitters in mimicking these actions of the natural transmitter, an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90116-6
更新日期：1983-12-12 00:00:00
abstract：:Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the administration of the hepa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.095
更新日期：2007-06-11 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:D-Fen-induced hyperthermia has been shown to coincide with an enhanced depletion of 5-HT and 5-hydroxyindole acetic acid (5-HIAA). Because these observations have relied on D-Fen exposure at multiple environmental temperatures, some have questioned the validity of the findings. Therefore, this experiment was designed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01732-1
更新日期：1999-08-28 00:00:00
abstract：:Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91111-d
更新日期：1991-05-10 00:00:00
abstract：:The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91077-3
更新日期：1988-03-29 00:00:00
abstract：:In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article, we select a few examples of recent advances in neuroscience and discuss their application or potential application to the study of motoneurons and the control of movemen...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.06.008
更新日期：2011-08-29 00:00:00
abstract：:The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90798-r
更新日期：1993-09-17 00:00:00
abstract：:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01318-c
更新日期：1995-02-13 00:00:00
abstract：:Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.009
更新日期：2006-12-13 00:00:00
