Abstract：
:Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.
journal_name
Brain Resjournal_title
Brain researchauthors
Wagner GC,Ricaurte GA,Seiden LS,Schuster CR,Miller RJ,Westley Jdoi
10.1016/0006-8993(80)91265-2subject
Has Abstractpub_date
1980-01-06 00:00:00pages
151-60issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(80)91265-2journal_volume
181pub_type
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