Abstract：
:Colchicine was injected into the region of the organum vasculosum lamina terminalis/anterior region of the third cerebral ventricle (OVLT/AV3V) to produce a temporary disruption of the nervous connections of this area and the rest of the anterior hypothalamus, but to maintain the vascular connections intact. Rats were kept in metabolism cages throughout the experiment and food and water intake plus urine and electrolyte excretion and body weight were measured each day. Food intake, body weight gain and urine and sodium excretion were reduced for several days after the injection of colchicine and the rats went into a marked positive sodium balance from the third day postinjection. Following 24 h water deprivation, 7 days after the colchicine injection, water intake was increased for 2 days. Urine and electrolyte excretion and food intake were also increased on the second day after the deprivation. Following a second deprivation, 10 days later, the colchicine-injected animals behaved as the control rats had done during both the deprivation periods. Injections of colchicine into the OVLT region of the AV3V, that would have blocked neural activity while maintaining a constant blood supply, produced some of the characteristics of a 'normal' lesion in this area; the rats decreased sodium excretion and increased their water intake in response to water deprivation. Therefore, colchicine may provide a useful means of investigating what role the constituent areas of the AV3V play in body fluid regulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Thornton SN,Sirinathsinghji DJ,Delaney CEdoi
10.1016/0006-8993(87)91648-9subject
Has Abstractpub_date
1987-12-29 00:00:00pages
339-44issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91648-9journal_volume
437pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00654-9
更新日期：1997-08-08 00:00:00
abstract：:Intrathecal administration of alpha(2) adrenergic agonists, such as clonidine, is capable of alleviating neuropathic pain. Recent studies suggest that spinal nitric oxide (NO) mediates the analgesic effect of intrathecal clonidine. Furthermore, compared to nicotinic receptors, spinal muscarinic receptors play a greate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02051-5
更新日期：2000-04-10 00:00:00
abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91253-w
更新日期：1991-09-27 00:00:00
abstract：:While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00726-7
更新日期：1995-09-18 00:00:00
abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.028
更新日期：2017-02-15 00:00:00
abstract：:A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90207-4
更新日期：1982-03-04 00:00:00
abstract：:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90953-2
更新日期：1982-10-28 00:00:00
abstract：:The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02672-x
更新日期：2000-09-22 00:00:00
abstract：:We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90169-v
更新日期：1991-07-19 00:00:00
abstract：:The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90566-1
更新日期：1975-10-10 00:00:00
abstract：:Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.003
更新日期：2004-07-02 00:00:00
abstract：:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.027
更新日期：2007-08-20 00:00:00
abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.003
更新日期：2016-09-15 00:00:00
abstract：:cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90409-x
更新日期：1994-08-08 00:00:00
abstract：:The visual properties of cells in the cat ventral lateral geniculate nucleus (LGV) identified antidromically from the pretectum and/or superior colliculus (projection cells) were studied in comparison with those of LGV neurons which could not be activated antidromically (non-projection cells). ON-phasic receptive fiel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90672-4
更新日期：1986-01-15 00:00:00
abstract：:The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90142-6
更新日期：1976-05-14 00:00:00
abstract：:Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147127
更新日期：2020-12-15 00:00:00
abstract：:Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03263-2
更新日期：2002-03-08 00:00:00
abstract：:The present experiments were designed to evaluate pharmacologically the role of three neuroanatomically related systems--dopamine, glutamate and GABA--in the motor-stimulant response to amphetamine and cocaine. The data indicate that stimulant-induced stereotypy is blocked by antagonists of all three systems and that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01334-e
更新日期：1995-02-06 00:00:00
abstract：:The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00522-r
更新日期：1995-08-07 00:00:00
abstract：:DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form of DJ-1, was observed in PD patients. DJ-1-binding compound B, which ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146641
更新日期：2020-02-15 00:00:00
abstract：:This study was designed to evaluate the role of spinal glutamatergic receptors in the antinociception elicited by agmatine in mice. Intraperitoneal (i.p.) administration of agmatine (1.0-100.0 mg/kg) dose dependently inhibited the nociceptive response induced by intrathecal (i.t.) injection of glutamate, N-methy-D-asp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.087
更新日期：2006-06-06 00:00:00
abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90087-8
更新日期：1986-09-01 00:00:00
abstract：:Effects of phenytoin (PHT) on the intracellular calcium and intracellular protein changes during pentylenetetrazole (PTZ)-induced bursting activity in the neurons of the Japanese land snail Euhadra peliomphala were examined. In the examination with a computer controlled electron probe X-ray microanalyzer, PHT clearly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91510-0
更新日期：1985-02-18 00:00:00
abstract：:Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.021
更新日期：2005-04-25 00:00:00
abstract：:Subtypes of muscarinic receptors were characterized in the frontal cortices of control and Alzheimer brains, with labelled quinuclidinyl benzilate [3H]QNB and the unlabelled muscarinic antagonists pirenzepine, AF-DX 116, hexahydro-sila-diphenidol (HHSiD), para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and himbacine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91541-l
更新日期：1992-11-20 00:00:00
abstract：:It is well established that autonomic control of digestive function is modulated by central autonomic neurotransmission. In this context it has been shown that digestive function can be modulated by exogenous neuropeptides microinjected into specific brain sides. Furthermore, there is considerable evidence suggesting ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.034
更新日期：2005-03-02 00:00:00
abstract：:The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90150-0
更新日期：1982-08-19 00:00:00
abstract：:The blink reflex consists of an early, pontine R1-component and a late, medullary R2-component. R1 and R2 can be evoked by innocuous stimuli, but only the R2 also by painful heat, suggesting that the R2 is mediated by wide dynamic range neurons (WDR) of the spinal trigeminal nucleus. Remote noxious stimuli suppress th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00646-5
更新日期：1998-08-24 00:00:00
abstract：:This study has presented cells, fibers and non-neuronal elements as seen in 3 dimensions using the SEM. Our discussion on possible artifacts which can occur with this method is offered in the hope that others will develop better techniques of dissection and specimen preparation. With the picture of normal tissue in mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(84)90006-7
更新日期：1984-12-01 00:00:00
