Abstract：
:The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was shown that 10(-5) M alpha-bungarotoxin from B. multicinctus completely blocks the response resulting from an increase in Cl permeability, while having no effect on either of the other two responses types (even when the toxin concentration was increased to 5 X 10(-5) M). The block of the Cl-dependent response by alpha-bungarotoxin is reversible. None of the three response types were affected by similar concentrations of alpha-toxin from B. caeruleus. Higher concentrations were not systematically tested. These results contradict reports of other authors on the action of alpha-bungarotoxin on molluscan acetylcholine (ACh) responses. Possible reasons for the discrepancies between our findings and those published by other authors are discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Kehoe J,Sealock R,Bon Cdoi
10.1016/0006-8993(76)90142-6subject
Has Abstractpub_date
1976-05-14 00:00:00pages
527-40issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(76)90142-6journal_volume
107pub_type
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