Abstract:
:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcumin significantly reduced olfactory bulbectomy-induced behavioral abnormalities including deficits in step-down passive avoidance, increased activity in the open area and immobility time. Chronic administration of curcumin significantly reversed levels of 3, 4-dihydroxyphenylacetic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid in the hippocampus region of male albino rats. Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Chang XR,Wang L,Li J,Wu DSdoi
10.1016/j.brainres.2016.03.010subject
Has Abstractpub_date
2016-07-01 00:00:00pages
219-225eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30135-4journal_volume
1642pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00362-4
更新日期:1997-06-06 00:00:00
abstract::In the adult rabbit, the somatostatin-immunoreactive neurons are seen in all visual cortical layers, with the majority of them being found in layers II-III, V and VI. During postnatal development, we can see labeled cells in layer VI at birth and in layers V and VI on the 3rd day. The labeled cells are seen in layers ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91456-8
更新日期:1985-12-16 00:00:00
abstract::The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of [3H]oxotremorine-M-acetate and oxotremorine/[3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90879-6
更新日期:1986-07-09 00:00:00
abstract::(1) Synaptic transmission was studied in isolated transverse hippocampal slices from guinea pigs. Extracellular evoked potentials were recorded in the region CA1. (2) Changing the normal perfusion solution (containing 2 mM Ca2+) to calcium-free Ringer abolished synaptic transmission which was again restored by adding ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91327-x
更新日期:1980-07-21 00:00:00
abstract::This study investigated the role of strain and vendor differences on the outcome of focal cerebral ischemia in the rat induced by occlusion of the middle cerebral artery by an intraluminal thread. The cortical infarct volumes (Mean +/- S.E.M.) were: 14.2 +/- 6.2 mm3 in Simonsen Laboratories Sprague-Dawley rats; 84.0 +...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00033-m
更新日期:1995-03-27 00:00:00
abstract::The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2008.08.078
更新日期:2008-10-27 00:00:00
abstract::The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory eff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)01965-x
更新日期:2000-03-17 00:00:00
abstract::We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00644-6
更新日期:1995-09-04 00:00:00
abstract::Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01094-7
更新日期:1995-12-12 00:00:00
abstract::This study shows that in the choroid plexus of Rana esculenta particulate guanylate cyclase (GC) is appreciably stimulated by porcine brain natriuretic peptide (BNP). Ultracytochemical tests for GC show that BNP notably increases the enzymatic reaction product along the apical surfaces of the epithelial cells. It can ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01178-1
更新日期:1995-12-24 00:00:00
abstract::The rate and pattern of seizure development provoked by repeated electrical stimulation of the amygdala (kindling) was assessed in rats that had been pretreated with intracerebral injections of the selective catecholaminergic neurotoxin 6-hydroxy-dopamine. Rats with selective depletion of forebrain noradrenaline displ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90289-9
更新日期:1980-05-26 00:00:00
abstract::The Thy-1 antigen is a cell surface glycoprotein found in neural tissue of all mammalian species so far studied. The distribution and amount of this antigen has been measured on 4 human neuronal and 2 neuroglial cell lines and on fresh tumour cells of neuronal origin. In 3 out of 4 neuronal lines (LAN-1, TR14, CHP 212...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90727-2
更新日期:1982-03-25 00:00:00
abstract::Horseradish peroxidase (HRP) was used as a retrograde tracer to identify the distribution pattern of labeled cells in the inferior olivary nucleus (IO) of Tupaia. Crystallized HRP was implanted into dorsal (DPML) and ventral (VPML) divisions of the paramedian lobule (PML) and, following appropriate survival times, the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90433-5
更新日期:1984-07-09 00:00:00
abstract::In the schedule-induced polydipsia model, hungry rats receiving a food pellet every minute will display excessive drinking behaviour (compulsive behaviour). We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.043
更新日期:2008-03-27 00:00:00
abstract::The second phase of Ca2+ transients (aequorin luminescence) which was not accompanied by twitch tensions were generated by 0.3 microM neostigmine in indirectly-stimulated diaphragm muscles of mice. This phase was dependent on external [Ca2+]o, was inhibited by a low concentration of (+)-tubocurarine (+)-TC; 0.013-0.13...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90287-l
更新日期:1990-01-22 00:00:00
abstract::In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90763-2
更新日期:1985-09-23 00:00:00
abstract::Glutamate induced responses in the surface membrane of Xenopus oocyte by injection with mRNA from crustacea and insect muscle. Glutamate (10(-5) to 10(-4) M) elicited smooth current responses which resembled those induced by kainate. This smooth current reversed direction at about 0 mV and was blocked by a spider toxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90048-9
更新日期:1987-12-01 00:00:00
abstract::Intracisternal injections of hypocretin-1 (hcrt-1) have been shown to elicit sympathoexciatory responses. However, the location of central sites that may mediate these cardiovascular effects have not been clearly elucidated. This study was done in male Wistar rats to investigate the effects of microinjections of hcrt-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.008
更新日期:2003-11-21 00:00:00
abstract::Knife cuts in the frontal plane separating the anterior part of the caudate-putamen from the globus pallidus resulted in marked decreases in substances P levels in the reticular part of the substantia nigra. More caudal knife cuts were required in order to effect maximal decreases in nigral glutamic acid decarboxylase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)91034-4
更新日期:1977-10-28 00:00:00
abstract::The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90269-9
更新日期:1981-08-24 00:00:00
abstract::The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.015
更新日期:2014-11-24 00:00:00
abstract::Drebrins are developmentally regulated proteins found in chicken brain and are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). Although the time courses of their appearance are different from each other, the structures of the 3 forms are closely related. Two kinds of dre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(88)90027-7
更新日期:1988-11-01 00:00:00
abstract::Factors underlying paired-pulse facilitation (PPF) were studied by intracellular and field recordings of CA1 neurons in the hippocampal slice in vitro, following stimulation of the Schaffer collaterals apical dendritic afferents. Similar magnitudes of PPF were found using the slopes or peaks of the excitatory postsyna...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90209-7
更新日期:1994-07-04 00:00:00
abstract::We examined the radical-scavenging activity of docosahexaenoic acid (DHA) and its effects on the neuronal cell death induced by oxidative or hypoxic stress in cultured retinal ganglion cells (RGC-5, a rat ganglion cell-line transformed using E1A virus). The radical-scavenging activity [hydrogen peroxide (H(2)O(2)), su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.031
更新日期:2009-01-28 00:00:00
abstract::Dissociated 4-day (stage 23) chick embryo lumbar cord cells were cultured at low or high cell densities for 1 or 5 days in the presence or absence of added spinal neuronotrophic factor (supplied as RN22 Schwannoma conditioned medium, RCM). In low density, 1-day cultures neuronal survival was dependent on added RCM whe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91039-9
更新日期:1983-05-09 00:00:00
abstract::To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90205-5
更新日期:1983-12-01 00:00:00
abstract::In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90084-8
更新日期:1985-07-29 00:00:00
abstract::The postnatal development of the distribution of 3 different ionic channel proteins in rat brain was studied using light microscopic autoradiography. [3H]Ethylenediaminetetrodotoxin, [125I]apamin and (-)-[3H]desmethoxyverapamil were used to label one class of voltage-dependent Na+ channel proteins, one class of Ca2+-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90175-2
更新日期:1987-08-04 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) can initiate an energy-consuming and inefficient repair cycle following cerebral ischemia/reperfusion by transferring ADP ribose units to nuclear proteins eventually leading to cellular dysfunction and neuronal death. 3-Aminobenzamide (3-AB) is a selective inhibitor of PARP that can ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02852-9
更新日期:2001-10-12 00:00:00
abstract::The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90211-7
更新日期:1979-04-27 00:00:00