Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats.

Abstract:

:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcumin significantly reduced olfactory bulbectomy-induced behavioral abnormalities including deficits in step-down passive avoidance, increased activity in the open area and immobility time. Chronic administration of curcumin significantly reversed levels of 3, 4-dihydroxyphenylacetic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid in the hippocampus region of male albino rats. Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats.

journal_name

Brain Res

journal_title

Brain research

authors

Chang XR,Wang L,Li J,Wu DS

doi

10.1016/j.brainres.2016.03.010

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

219-225

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(16)30135-4

journal_volume

1642

pub_type

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