Abstract:
:Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male and female rats on days 24, 50 and 70 after birth. Animals used in this experiment were born of mothers that received delta 9-THC (5 mg/kg; p.o.) daily from day 5 of pregnancy until day 24 after offspring birth. delta 9-THC perinatally treated males, but not females, showed higher baseline tail-flick values than controls on days 24 and 50 (Day 24, controls: 3.88 +/- 0.18 s; delta 9-THC group: 4.51 +/- 0.18 s; Day 50, controls: 3.16 +/- 0.17 s; delta 9-THC group: 4.38 +/- 0.38 s). In addition, adult males were found to be tolerant to the analgesic effect of morphine (5 mg/kg; i.p.; % analgesia: controls 71.75 +/- 10.20; delta 9-THC 35.5 +/- 10.59). Moreover, recently weaned pups that received 5 mg/kg of naloxone (i.p.) developed an opioid-like withdrawal syndrome. Taken together all these results suggest that perinatal treatment with delta 9-THC may alter the functionality of the endogenous opioid system, including changes in pain sensitivity.
journal_name
Brain Resjournal_title
Brain researchauthors
Vela G,Fuentes JA,Bonnin A,Fernández-Ruiz J,Ruiz-Gayo Mdoi
10.1016/0006-8993(95)00255-osubject
Has Abstractpub_date
1995-05-22 00:00:00pages
142-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00255-Ojournal_volume
680pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::For the purpose of obtaining chemical information about the physiological role of N-acetylaspartylglutamate (NAAG), the release of endogenous NAAG from and the uptake of [3H]NAAG by Guinea pig cerebellar slices were investigated in comparison with L-aspartate (Asp) and L-glutamate (Glu). Although endogenous NAAG was f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90544-1
更新日期:1989-03-13 00:00:00
abstract::Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91202-r
更新日期:1990-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.07.039
更新日期:2014-09-25 00:00:00
abstract::Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02033-3
更新日期:2000-03-31 00:00:00
abstract::The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90791-9
更新日期:1990-10-29 00:00:00
abstract:OBJECTIVE:This study aimed to investigate whether β-amyloid (Aβ) was able to enhance neurocan expression in a Sox9 dependent manner in astrocytes. METHODS AND MATERIALS:Astrocytes were incubated with Aβ at different concentrations, the expression of Sox9 and neurocan was detected by Western blot assay. Meanwhile, the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.06.010
更新日期:2016-09-01 00:00:00
abstract::Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.006
更新日期:2015-11-02 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is implicated in the temporal organization of circadian rhythms in a variety of physiological, endocrine and behavioral processes. There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90689-0
更新日期:1994-07-18 00:00:00
abstract::Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimulations (100 microA at 1 min intervals) delivered once per day for 14 c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.006
更新日期:2004-04-02 00:00:00
abstract::We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90757-m
更新日期:1991-10-04 00:00:00
abstract::Opioid antagonists block the positive hedonic response to food taste and are potent inhibitors of palatability-driven feeding. However, the specific brain regions within which opioid peptide secretion contributes to the maintenance of palatability-driven feeding have not been clearly established. In the present study,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00719-7
更新日期:1998-09-14 00:00:00
abstract::Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. The GluR2 sub...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.123
更新日期:2006-02-23 00:00:00
abstract::The present study was undertaken to investigate in rats the role of the noradrenergic innervation of the hippocampus in the reversal by antidepressant drugs of escape failures caused by previous exposure to inescapable shocks (learned helplessness design). Rats were either sham-operated or given a bilateral infusion o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91646-5
更新日期:1987-12-29 00:00:00
abstract::Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91893-7
更新日期:1994-03-21 00:00:00
abstract::There is increasing evidence that traumatic brain injury (TBI) induces hypofunction of the striatal dopaminergic system, the mechanisms of which are unknown. In this study, we analyzed the activity of striatal tyrosine hydroxylase (TH) in rats at 1 day, 1 week, and 4 weeks after TBI using the controlled cortical impac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.096
更新日期:2011-01-19 00:00:00
abstract::The present study was designed to investigate the distribution of serotonin 5-HT1A receptor protein (5-HT1A-immunoreactivity) and its localization within cortical pyramidal neurons of the rat cingulate cortex. This experimental direction was inspired by recent data showing the role of 5-HT1A receptors in the pathology...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03352-3
更新日期:2003-10-31 00:00:00
abstract::Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical cir...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02170-3
更新日期:2000-07-07 00:00:00
abstract::The effects of hyperbaric oxygen have been studied on synaptic transmission in the hippocampal brain slice. Oxygen enhances both the prevolley and postsynaptic potential of extracellularly recorded responses following focal stimulation of afferent fiber bundles, but synaptic efficiency is reduced. It is suggested that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90775-8
更新日期:1983-01-31 00:00:00
abstract::Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90929-x
更新日期:1976-03-19 00:00:00
abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91419-4
更新日期:1989-01-16 00:00:00
abstract::We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00258-8
更新日期:1997-06-13 00:00:00
abstract::Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.09.056
更新日期:2011-12-02 00:00:00
abstract::Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02768-9
更新日期:2003-07-18 00:00:00
abstract::Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.087
更新日期:2008-11-25 00:00:00
abstract::The amount of myelin and its protein composition was studied in hypothyroid rats during the first 30 days after birth. Although the brain weight was 92% of that in the controls, the yield of myelin in hypothyroid animals was only 60% of that in controls. The protein and glycoprotein ocmposition of the isolated myelin ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90764-7
更新日期:1975-02-14 00:00:00
abstract::We have previously shown that blockade of neurotransmission mediated by gamma-aminobutyric acid (GABA) in the ventromedial nucleus of the hypothalamus (VMH) by the microinjection of a GABAA receptor antagonist, bicuculline methiodide (BM), exclusively induced running activity in the rat. The purpose of the present stu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91243-l
更新日期:1993-02-19 00:00:00
abstract::Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotransmitter dysregulations within mesolimbic system. Adenosine 5'-triph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.05.025
更新日期:2019-09-15 00:00:00
abstract::In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2021.147277
更新日期:2021-01-07 00:00:00
abstract::Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01161-5
更新日期:1999-01-23 00:00:00
abstract::Double-staining in either vibratome or paraffin sections using contrasting chromogens revealed an alpha-melanocyte-stimulating hormone (alpha-MSH)-containing cell group in the arcuate nucleus, a metorphamide-containing cell group in the paraventricular hypothalamus, and an extensive group of magnocellular perikarya in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90012-1
更新日期:1988-06-14 00:00:00