Abstract:
:The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent manner with an EC50 of 4.5 microM. GABA, 3-aminopropanesulphonic acid (3APS) and muscimol did not affect PIPs breakdown, but they strongly increased (greater than 100%) PIPs metabolism induced by 1 microM NE. Their action was antagonized by bicuculline (10 microM). We discuss the implications of these findings in hippocampal neurotransmission.
journal_name
Brain Resjournal_title
Brain researchauthors
Corradetti R,Ruggiero M,Chiarugi VP,Pepeu Gdoi
10.1016/0006-8993(87)90701-3subject
Has Abstractpub_date
1987-05-12 00:00:00pages
196-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90701-3journal_volume
411pub_type
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