GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices.

Abstract:

:The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent manner with an EC50 of 4.5 microM. GABA, 3-aminopropanesulphonic acid (3APS) and muscimol did not affect PIPs breakdown, but they strongly increased (greater than 100%) PIPs metabolism induced by 1 microM NE. Their action was antagonized by bicuculline (10 microM). We discuss the implications of these findings in hippocampal neurotransmission.

journal_name

Brain Res

journal_title

Brain research

authors

Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

doi

10.1016/0006-8993(87)90701-3

subject

Has Abstract

pub_date

1987-05-12 00:00:00

pages

196-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90701-3

journal_volume

411

pub_type

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