Abstract：
:Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant path kindling. MK-801 (0.1 and 1.0 mg/kg) blocked induction of LTP of the perforant path in the unanesthetized animal measured 24 h after train delivery. The 1.0 mg/kg dosage also increased afterdischarge (AD) thresholds, delayed kindling development from daily stimulation of the perforant path (means = 8.82 +/- 1.19 and 22.9 +/- 3.66 sessions to the first stage 5 seizure), and increased AD durations. Kindling produced a significant potentiation of the EPSP (47%) and population spike (49%) after the first evoked AD in control animals. No significant enhancement of either component of the field potential was observed in MK-801-treated animals. Animals treated with this dosage of MK-801, did, however, kindle in the absence of potentiation at this synapse. It was concluded that although NMDA-mediated potentiation may facilitate kindling, synaptic potentiation does not appear to be a critical requirement for kindling to develop. These findings support the notion that development of the burst response and not synaptic enhancement may be the critical physiological alteration that underlies the kindling phenomenon.
journal_name
Brain Resjournal_title
Brain researchauthors
Gilbert ME,Mack CMdoi
10.1016/0006-8993(90)90064-isubject
Has Abstractpub_date
1990-06-11 00:00:00pages
89-96issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(90)90064-Ijournal_volume
519pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90342-7
更新日期：1992-05-22 00:00:00
abstract：:The medial preoptic nucleus (MPN) of the medial preoptic area (MPOA) and the medial amygdala are two brain regions in which male rat sexual behavior increased Fos-like immunoreactivity (Fos-Li). Dopamine is released in the MPOA during male rat sexual behavior and facilitates copulation. Psychostimulants, which increas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01338-4
更新日期：1999-05-22 00:00:00
abstract：:In prion diseases, metal imbalances in brain and/or metal substitutions for copper in prion protein suggest that metal-catalyzed oxidation (MCO) and oxidative stress may affect cellular function and accumulation of protease-resistant prion protein (PrP(Sc)). We examined the effect of metal-induced oxidative stress by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.117
更新日期：2008-10-31 00:00:00
abstract：:When the axons of goldfish retinal ganglion cells are severed the cell bodies undergo a series of changes as the axons regenerate. These changes begin to reverse when the axons start to innervate the tectum and by 3 months after the lesion the cell bodies have nearly returned to normal. When the axons projecting to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90824-9
更新日期：1987-10-13 00:00:00
abstract：:The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02289-1
更新日期：2000-02-07 00:00:00
abstract：:Due to the structural similarity to N-methyl-4-phenyl pyridinium (MPP(+)), paraquat might induce dopaminergic toxicity in the brain. However, its blood--brain barrier (BBB) penetration has not been well documented. We studied the manner of BBB penetration and neural cell uptake of paraquat using a brain microdialysis ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02577-x
更新日期：2001-07-06 00:00:00
abstract：:Recordings were made from single neurons in the rat's central nucleus of the inferior colliculus (ICc). Binaural responses were studied when dichotic tone bursts with various interaural-level differences were presented simultaneously or with a contralateral delay. These dichotic tone bursts allowed us to probe tempora...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.059
更新日期：2009-12-15 00:00:00
abstract：:GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.033
更新日期：2006-11-06 00:00:00
abstract：:The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.103
更新日期：2009-11-03 00:00:00
abstract：:Recent anatomical evidence suggests that the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, together referred to as the extended amygdala, may play a role in opiate dependence. The bed nucleus of the stria terminalis and the shell of the nucleus accumb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02288-x
更新日期：2000-01-31 00:00:00
abstract：:The glutamate analogue 2-amino-4-phosphonobutyric acid (AP4) is a potent antagonist at several synapses where an excitatory amino acid appears to be the neurotransmitter. Previous studies identified a Cl-/Ca2+ dependent [3H]glutamate binding site in synaptic plasma membrane (SPM) preparations that was also labeled by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90977-7
更新日期：1986-06-04 00:00:00
abstract：:The content of the mRNAs that code for prepro-corticotropin releasing hormone (ppCRH), prepro-neurotensin/neuromedin N (ppNT/NMN) and prepro-enkephalin (ppENK) was measured using in situ hybridization histochemistry in the various subdivisions of the hypothalamic paraventricular nucleus (PVH) 4 h after a bout of ether...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90080-f
更新日期：1991-03-29 00:00:00
abstract：:Recently, Somberg, in a preliminary report (1983), noted that electrical stimulation of the area postrema causes an increase in coronary vascular resistance. The increase in resistance was mediate by an increase in sympathetic activity as it was counteracted by alpha-adrenergic receptor blockade. The purpose of our st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91269-3
更新日期：1988-05-17 00:00:00
abstract：:The analgesic effect and its mechanism of electroacupuncture (EA) on inflammatory pain, especially in the rat model of collagen-induced arthritis (CIA), have not yet been studied. This study was designed to investigate the analgesic effect and its cholinergic and serotonergic mechanism of EA in the CIA rat model. To i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.014
更新日期：2005-09-28 00:00:00
abstract：:Origins of vestibular efferent fibers to ampulla of semicircular canals in cats were examined using retrograde transport of horseradish peroxidase. The anterior canal was innervated from bilateral parvocellular reticular nucleus (PCRN), contralateral gigantocellular reticular nucleus and ipsilateral lateral reticular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91261-1
更新日期：1983-01-24 00:00:00
abstract：:We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.07.051
更新日期：2015-10-22 00:00:00
abstract：:In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.01.032
更新日期：2015-04-07 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2013.01.008
更新日期：2013-05-20 00:00:00
abstract：:Serotonin (5-HT), dopamine (DA) and noradrenaline (NE) play important roles in brain postnatal maturation. Therefore, deficits in brain availability of biogenic amines during critical developmental phases might underlie neurodevelopmental disturbances associated with cognitive impairment. To test this hypothesis we ev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.006
更新日期：2008-06-27 00:00:00
abstract：:The distribution of glucagon-like peptide-1-(7-36)amide like immunoreactivity (GLP-1-(7-36)NH2 IR) in rat brain was determined. Highest concentrations were found in the hypothalamus. A combination of gel chromatography and anion exchange chromatography showed that the majority of hypothalamic immunoreactivity exactly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90628-8
更新日期：1989-11-20 00:00:00
abstract：:Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91973-9
更新日期：1994-11-21 00:00:00
abstract：:By means of the [14C]deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in the lateral geniculate nucleus and the superior colliculus of rats with a simultaneous double enucleation, animals with an enucleation of the right eye between neonatal and adult stages followed by an enucleation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90688-4
更新日期：1989-05-29 00:00:00
abstract：:Tyrosine hydroxylase immunohistochemical examination of the mesencephalon of severely parkinsonian MPTP-treated macaque fascicularis monkeys revealed a marked loss of substantia nigra pars compacta (SNc) neurons in both medial and central portions of the nucleus with a relative sparing of neurons in the dorsal-most po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90691-3
更新日期：1987-05-12 00:00:00
abstract：:The regional distribution of proline biosynthetic enzymes, ornithine-delta-aminotransferase and delta 1-pyrroline-5-carboxylate reductase, in the rat brain, and basic conditions for proline synthesis from ornithine in rat and chicken brain slices and chicken retinas were investigated. The cerebral regions relating to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91022-5
更新日期：1987-06-16 00:00:00
abstract：:Following injections of WGA-HRP into lower cervical segments, the distribution of anterograde labeled terminals of spinocerebellar fibers was examined in the vermal cortex of the cat. The labeled terminals were seen in sublobules Ib to VIc, VIIb, VIIIa and VIIIb, and lobule IX. They were present mainly in the medial p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91261-2
更新日期：1985-12-23 00:00:00
abstract：:Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01060-3
更新日期：1997-12-05 00:00:00
abstract：:The use of two different radioligands, [125I]Leu8, D-Tryp22,Tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125I]204-090, D-Phe-Cys[125I]Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. In homogenates, octapeptide somato...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90813-4
更新日期：1987-03-17 00:00:00
abstract：:The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91740-x
更新日期：1994-03-14 00:00:00
abstract：:The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90323-8
更新日期：1984-06-25 00:00:00
