Abstract：
:The medial preoptic nucleus (MPN) of the medial preoptic area (MPOA) and the medial amygdala are two brain regions in which male rat sexual behavior increased Fos-like immunoreactivity (Fos-Li). Dopamine is released in the MPOA during male rat sexual behavior and facilitates copulation. Psychostimulants, which increase dopamine levels, induce Fos-Li in the striatum through D1 receptors. We examined whether copulation-induced Fos-Li in the MPN was also mediated through D1 receptors. In Experiment 1, sexually inexperienced male rats that received the D1 antagonist Schering 39166 prior to their first sexual experience had fewer Fos-Li cells in the MPN than did those that received vehicle. In Experiment 2, no significant effect of the D1 antagonist was observed on copulation-induced Fos-Li in male rats that had received repeated sexual experiences prior to the drug test day. Sexual experience increases copulatory efficiency; the mechanisms by which this improvement occurs are unclear. In Experiment 3, copulation by highly experienced male rats led to greater Fos-Li in the MPN than did copulation by sexually naive males. Although there were no differences between groups in amygdala Fos-Li in these studies, in several groups Fos-Li in the medial amygdala was positively correlated with the post-ejaculatory interval. These experiments indicate that (1) stimulation of D1 receptors may contribute to the transient copulation-induced increase in Fos-Li in the MPN, and (2) repeated sexual experiences enhanced copulation-induced Fos-Li in the MPN, which may represent a marker of altered responsiveness of neurons in the MPN to sexual or conditioned stimuli.
journal_name
Brain Resjournal_title
Brain researchauthors
Lumley LA,Hull EMdoi
10.1016/s0006-8993(99)01338-4subject
Has Abstractpub_date
1999-05-22 00:00:00pages
55-68issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01338-4journal_volume
829pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:To gain greater insight on the molecular mechanisms that underlie ischemic stroke, we compared gene expression profiles in transient (tMCAO) and permanent middle cerebral artery occlusion (pMCAO) stroke models using Expression Analysis Systematic Explorer (EASE) pathway analysis software. Many transcripts were induced...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.090
更新日期：2006-02-03 00:00:00
abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00155-j
更新日期：1995-04-24 00:00:00
abstract：:The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor. In this study we have used ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00052-r
更新日期：1995-04-03 00:00:00
abstract：:Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90007-4
更新日期：1975-11-14 00:00:00
abstract：:This study was conducted on unanesthetized rainbow trout equipped with two ECG electrodes and with an intracerebroventricular (i.c.v.) micro-guide. The ECG signal was recorded during three experimental sessions of 30 min and the heart rate variability (HRV) spectral analysis was performed during stabilized periods of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02903-7
更新日期：2002-08-23 00:00:00
abstract：:Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these funct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.010
更新日期：2010-01-22 00:00:00
abstract：:Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.028
更新日期：2009-12-11 00:00:00
abstract：:We have successfully constructed a mouse neuronal N1E-115 cell line stably expressing a fully functional human dopamine transporter (hDAT). Previous studies in our laboratory have produced several anti-idiotypic Ab2beta antibodies that mimic the configuration of the cocaine molecule at their antigen-combining site. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02491-4
更新日期：2000-07-28 00:00:00
abstract：:Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90728-5
更新日期：1979-07-27 00:00:00
abstract：BACKGROUND:Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder which is characterized by altered bowel habits. A growing number of studies investigate the association between IBS and cognitive impairments. Current studies report conflicting results regarding cognitive impairment in IBS patie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.036
更新日期：2019-09-15 00:00:00
abstract：:Glutamate carboxypeptidase II may modulate excitatory neurotransmission through the catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) and possibly other endogenous peptide substrates. To investigate the molecular properties of cloned human GCP II (hGCP II), we analyzed the NAAG-hydrolytic activity convey...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00244-3
更新日期：1998-06-08 00:00:00
abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.027
更新日期：2017-01-01 00:00:00
abstract：:Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90096-2
更新日期：1983-01-01 00:00:00
abstract：:The effects of exogenous Cushing's syndrome on the brain metabolism were investigated by proton magnetic resonance spectroscopy (MRS). Thirteen patients having been treated for 2 to 22 years with prednisone were recruited. On the average, none of the metabolites (NAA, Cr, Cho and mI) were significantly different from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02697-x
更新日期：2001-08-24 00:00:00
abstract：:Pars interpolaris of the spinal trigeminal nucleus of kittens has been studied with the electron microscope at birth and at several subsequent ages during the first month of life. Attention has been given to ultrastructural maturational changes that occur in this neuropil, especially events in synaptogenesis. The resu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90354-2
更新日期：1978-03-31 00:00:00
abstract：:Ischemic insults affecting the internal capsule result in sensory-motor disabilities which adversely affect the patient's life. Cerebral endothelial cells have been reported to exert a protective effect against brain damage, so the transplantation of healthy endothelial cells might have a beneficial effect on the outc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.042
更新日期：2012-08-21 00:00:00
abstract：:Cerebral cells of origin for the corticospinal (CST), corticopontine (CP), corticorubral (CR) and corticostriatal (CS) fibers in the rat were identified following the simultaneous retrograde transport of propidium iodide (PI), fast blue (FB), fluorogold (FG) and diamidino yellow (DY). PI was injected into the contrala...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91629-s
更新日期：1992-07-24 00:00:00
abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00779-8
更新日期：1997-10-10 00:00:00
abstract：:Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.09.009
更新日期：2018-12-15 00:00:00
abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90087-8
更新日期：1986-09-01 00:00:00
abstract：:Knife cuts in the frontal plane separating the anterior part of the caudate-putamen from the globus pallidus resulted in marked decreases in substances P levels in the reticular part of the substantia nigra. More caudal knife cuts were required in order to effect maximal decreases in nigral glutamic acid decarboxylase...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)91034-4
更新日期：1977-10-28 00:00:00
abstract：:125I-alpha-Scorpion toxin (alpha-ScTx) binds to a component of the voltage-sensitive Na+ channel. We have previously shown that receptor capacity on dissociated mouse brain cells increases between days 12 and 19 of fetal life as does the expression of neurotoxin-sensitive 22Na+ influx. In the present study we have inv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90136-2
更新日期：1987-03-01 00:00:00
abstract：:The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.017
更新日期：2005-11-23 00:00:00
abstract：:Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.087
更新日期：2008-11-25 00:00:00
abstract：:Experiments were done in chloralose anesthetized, paralyzed and artificially ventilated cats to identify single units in ventrolateral medulla (VLM) projecting directly to the intermediate gray (IG) region of the upper thoracic cord and responding to inputs from pressor sites in the anterior lateral hypothalamus (Hla)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90908-4
更新日期：1985-11-11 00:00:00
abstract：:Production of inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6), in the brain is increased in various diseases. To investigate the relationships between the effect of overproduction of IL-6 in the brain on central and peripheral production of TNF, IL-1 beta an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00865-7
更新日期：1996-11-18 00:00:00
abstract：:An apparent binding activity of [3H]glutathione was examined by using synaptic membrane preparations of the rat brain. The activity was found to be more than two times as high at 30 degrees C as that found at 2 degrees C. At 2 degrees C, the apparent binding sites consisted of a single component with a Kd of 0.77 micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90524-0
更新日期：1988-10-25 00:00:00
abstract：:In addition to its stimulatory effect on prolactin release, the neuropeptide prolactin releasing peptide (PrRP) has been shown to be a mediator of the stress response. To analyze the neurochemical properties of the cells responsive to PrRP and involved in stress modulation, we examined PrRP receptor co-expression with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03183-9
更新日期：2002-10-11 00:00:00
abstract：:We investigated the effects of inverting facial contour (hair and chin) and features (eyes, nose and mouth) on processing for static and dynamic face perception using magnetoencephalography (MEG). We used apparent motion, in which the first stimulus (S1) was replaced by a second stimulus (S2) with no interstimulus int...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.091
更新日期：2011-04-06 00:00:00
abstract：:The myelin vacuolation (mv) rat exhibits hypomyelination and vacuole formation in the myelin throughout the CNS, caused by a null mutation in the attractin gene. Myelin alterations in the spinal cord of mv rats progress during postnatal development and are more prominent in the white matter. In contrast, microglial ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.027
更新日期：2010-02-02 00:00:00
