Abstract:
:In addition to its stimulatory effect on prolactin release, the neuropeptide prolactin releasing peptide (PrRP) has been shown to be a mediator of the stress response. To analyze the neurochemical properties of the cells responsive to PrRP and involved in stress modulation, we examined PrRP receptor co-expression with two neuropeptides involved in stress, corticotropin releasing hormone (CRH) and enkephalin (ENK). We find that although PrRP receptor is highly expressed in the parvocellular division of the paraventricular nucleus of hypothalamus (PVN), the majority of the cells expressing PrRP receptor are neither CRH- nor ENK-positive. The only region where the PrRP receptor co-expresses extensively with CRH is the bed nucleus of the stria terminalis (BST). There is also a small number of cells positive for CRH and PrRP receptor in the central nucleus of amygdala (CEA), while the remaining PrRP receptor-positive cells co-express ENK. Furthermore we find that the PrRP receptor-expressing neurons in the brainstem parabrachial nucleus (PB) largely express ENK rather than CRH. From these results we propose a model in which PrRP modulates the hypothalamic-pituitary-adrenal axis through trans-synaptic modulation of hypothalamic CRH release rather than through direct activation of PVN neurons. We also suggest that PrRP may modulate nociception by virtue of its receptor's co-expression with ENK in PB. Our results provide a theoretical framework by which future studies examining the role of PrRP in brain could be elucidated.
journal_name
Brain Resjournal_title
Brain researchauthors
Lin SH,Leslie FM,Civelli Odoi
10.1016/s0006-8993(02)03183-9subject
Has Abstractpub_date
2002-10-11 00:00:00pages
15-30issue
1eissn
0006-8993issn
1872-6240pii
S0006899302031839journal_volume
952pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Single cell recordings were made from neurons in the lateral tegmental field of the medulla (LTFM) during electrical stimulation of the hypothalamic defense area (HDA) of the rabbit. Fifty-four cells were inhibited by HDA stimulation; 23 of these cells received barosensory input. Twenty-two LTFM cells showed an increa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90738-h
更新日期:1991-08-30 00:00:00
abstract::Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91273-j
更新日期:1990-01-08 00:00:00
abstract::Previous studies have shown that long-term 5-hydroxytryptamine (5-HT) depletion induced by combined dorsal and median raphe injections of 5,7-dihydroxytryptamine (5,7-DHT) leads to impairments in the acquisition and performance of behaviour maintained under a differential-reinforcement-of-low-rate (DRL) schedule of re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00037-q
更新日期:1995-03-27 00:00:00
abstract::The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91363-1
更新日期:1987-02-24 00:00:00
abstract::To examine the structural interactions between synaptically connected neurons in Aplysia, we have developed a method for simultaneously labeling two identified cell with different and compatible intraneuronal marking agents (horseradish peroxidase and [3H]N-acetyl-D-galactosamine) visible in both the light and electro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90621-8
更新日期:1979-09-14 00:00:00
abstract::Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.129
更新日期:2006-05-04 00:00:00
abstract::We compared the relative abilities of a series of calmodulin inhibitors and protein kinase C inhibitors to influence 45Ca2+ influx through voltage-dependent Ca2+ channels in PC12, a clonal neural cell line. K+-depolarization-dependent 45Ca2+ uptake was reduced by the calmodulin inhibitors calmidazolium, trifluoperazin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91403-x
更新日期:1987-02-24 00:00:00
abstract::The tax-4 and tax-2 genes of Caenorhabditis elegans are essential for normal olfaction, gustation, and thermosensation, suggesting that they have a role in sensory transduction. The predicted products of these genes are similar to the cyclic nucleotide-gated (CNG) channel subunits used in vertebrate vision and olfacti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01111-7
更新日期:1999-03-06 00:00:00
abstract::A commissural-associational entorhino-entorhinal projection in the guinea pig was analyzed using anterograde and retrograde axonal tracing techniques. The projection originated in layer II and terminated in layer Ia of both the medial entorhinal area (MEA) and the lateral entorhinal area (LEA). A few cells in other la...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90117-0
更新日期:1989-12-25 00:00:00
abstract::The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90305-3
更新日期:1989-10-23 00:00:00
abstract::Hypoxia preconditioning states that a sublethal hypoxia period will afford neuroprotection against a second harmful event. In our experiments, we carried out a procedure for the development of hypoxia preconditioning in adult male Wistar rats using hypoxic exposure (9% O(2); 91% N(2)) for 1 h. The protection against p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02388-x
更新日期:2000-06-16 00:00:00
abstract::In previous studies we have tested the hypothesis that the termination of the period of sexual behavior in female guinea pigs results from the loss of progestin receptors from hypothalamic cell nuclei. We have shown that hormonal manipulations that delay heat termination also delay loss of hypothalamic nuclear progest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90320-3
更新日期:1986-05-14 00:00:00
abstract::Focal cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators (Clark et al., Brain Res. Bull., 35 (1994) 387-392; Garcia et al., Am. J. Pathol., 144 (1994) 188-199; Wang et al., J. Neurochem. 71 (1998) 1194-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02328-9
更新日期:2001-06-01 00:00:00
abstract::Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.07.039
更新日期:2014-09-25 00:00:00
abstract::Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.06.010
更新日期:2017-09-01 00:00:00
abstract::Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00039-0
更新日期:1998-03-30 00:00:00
abstract::Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91009-6
更新日期:1984-08-20 00:00:00
abstract::Choroid plexuses from the lateral (LVCP) and fourth ventricles (FVCP) of rats or rabbits were incubated in artificial cerebrospinal fluid (CSF) containing 1 microM [14C]L-carnitine with various concentrations of L-carnitine ranging from 0.01 mM to 1.0 mM. The time course of 1 microM [14C]L-carnitine uptake by the chor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90188-2
更新日期:1991-07-19 00:00:00
abstract::Spatial neglect may involve neglect dyslexia resulting in a failure to identify words or parts of words in the contralesional hemispace. The present study explored a well-documented dissociation in neglect dyslexics' word processing, i.e. impaired reading aloud in the presence of good lexical decision performance for ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.069
更新日期:2008-01-16 00:00:00
abstract::Depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (DAT). One possible mechanism for the cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine. To test this hypothesis, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01033-5
更新日期:1996-12-02 00:00:00
abstract::Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.11.004
更新日期:2016-01-01 00:00:00
abstract::The nucleus accumbens and ventral pallidum receive dopamine (DA) projections from the mesencephalon. Although DA inputs to the nucleus accumbens are implicated in both locomotion and reward processes, little is known of the behavioural significance of DA in the ventral pallidum. These studies examined the effects of D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00633-7
更新日期:1998-09-14 00:00:00
abstract::Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90147-1
更新日期:1986-02-01 00:00:00
abstract::Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00771-h
更新日期:1995-11-06 00:00:00
abstract::Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91327-6
更新日期:1983-04-11 00:00:00
abstract::The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of [3H]oxotremorine-M-acetate and oxotremorine/[3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90879-6
更新日期:1986-07-09 00:00:00
abstract::Calretinin and calbindin-D28k are two calcium-binding proteins which are present in separate populations of interneurons in cerebral cortex and hippocampus. To identify these cells with the populations expressing different transmitters, two-colour immunofluorescence was done with antibodies against the calcium-binding...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91439-l
更新日期:1992-07-31 00:00:00
abstract::The purpose of this experiment was to determine whether increased secretion of somatostatin or alterations in its molecular form contribute to the age-related decline in growth hormone secretion. Median eminences were removed from male Sprague-Dawley rats (3-4 and 21-24 months of age) and superfused with Krebs-Ringer ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90217-9
更新日期:1986-08-20 00:00:00
abstract::It has been accepted that the descending system from the nucleus locus coeruleus (LC)/nucleus subcoeruleus (SC) plays a significant role in spinal nociceptive processing. The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the tri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.023
更新日期:2003-12-12 00:00:00
abstract::Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.057
更新日期:2010-07-30 00:00:00