Abstract：
:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitional forelimb strength and quantify forelimb weakness following traumatic brain injury. In this paper, we report the ability of the isometric pull task to measure both acute and chronic impairments in forelimb motor function following a controlled cortical impact (CCI) in rodents. Following CCI, volitional forelimb strength is reduced by 36% and remains significantly reduced after 6 weeks of post-lesion training. We also show that CCI results in impairment of multiple additional measures of forelimb function for several weeks post-injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Pruitt D,Hays S,Schmid A,Choua C,Kim L,Trieu J,Kilgard MP,Rennaker RL 2nddoi
10.1016/j.brainres.2014.07.039subject
Has Abstractpub_date
2014-09-25 00:00:00pages
91-8eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01012-9journal_volume
1582pub_type
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