High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.

abstract：:L-[35S]Methionine was injected into the dorsal root ganglion (L5) of the adult rat, and migration of the neurofilament polypeptides (the triplet with molecular weights of 200,000, 160,000 and 68,000 daltons), alpha- and beta-tubulins and actin in the sciatic nerve and the dorsal root was quantitatively determined and ...

journal_title：Brain research

authors： Komiya Y,Kurokawa M

更新日期：1980-05-26 00:00:00

abstract：:We have previously shown that blockade of neurotransmission mediated by gamma-aminobutyric acid (GABA) in the ventromedial nucleus of the hypothalamus (VMH) by the microinjection of a GABAA receptor antagonist, bicuculline methiodide (BM), exclusively induced running activity in the rat. The purpose of the present stu...

journal_title：Brain research

authors： Narita K,Yokawa T,Nishihara M,Takahashi M

更新日期：1993-02-19 00:00:00

abstract：:Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-sp...

journal_title：Brain research

authors： Di Domenico F,Casalena G,Sultana R,Cai J,Pierce WM,Perluigi M,Cini C,Baracca A,Solaini G,Lenaz G,Jia J,Dziennis S,Murphy SJ,Alkayed NJ,Butterfield DA

更新日期：2010-11-29 00:00:00

abstract：:Microtubule-stabilizing drugs are useful in cancer therapy and show promise for treatment of neurodegenerative diseases. An overlapping binding site between tau and taxoid site drugs has led to a number of research papers investigating the competitive interaction between these drugs and the microtubule. This has impli...

journal_title：Brain research

authors： Das V,Miller JH

更新日期：2012-12-13 00:00:00

abstract：:A possible functional relationship between corticotropin-releasing factor (CRF) and opiate peptide neuronal systems (beta-endorphin, dynorphin1-17 and Met-enkephalin) and their interactions with gonadotropin releasing hormone (GnRH) in the mesencephalic central gray (MCG) for the regulation of lordosis behaviour was a...

journal_title：Brain research

authors： Sirinathsinghji DJ

更新日期：1985-06-10 00:00:00

abstract：:It has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. The data reviewed here, however, suggest that the oft-stated generalization that normal aging is characterized by disruption of cholinergic input to the hippoca...

journal_title：Brain research

authors： Decker MW

更新日期：1987-11-01 00:00:00

abstract：:Occipital cortex of 19-day-old fetal rats was dissociated and cultured in vitro for 2-5 weeks in horse serum supplemented Eagle's MEM. The outgrowing neurons rapidly formed a dense network which started to degenerate after 3 weeks in vitro. By means of electron microscopy the numerical development of 6 different categ...

journal_title：Brain research

authors： Romijn HJ,Mud MT,Habets AM,Wolters PS

更新日期：1981-07-01 00:00:00

abstract：:The anatomical structure of the basal ganglia indicates that the input from the cerebral cortex is funnelled through the striatum to the globus pallidus and substantia nigra. This structure implies integration of the information as it is transferred through the basal ganglia. In order to investigate this integration, ...

journal_title：Brain research

authors： Loopuijt LD,van der Kooy D

更新日期：1985-11-25 00:00:00

abstract：:GEC1 protein shares high identity with GABARAP (GABA(A) Receptor-Associated Protein), interacts with tubulin and GABA(A) receptors and is potentially involved in intracellular transport processes. Recently, using quantitative real time PCR, we have reported the gec1 mRNA expression in different rat brain areas. In the...

journal_title：Brain research

authors： Tolle F,Risold PY,Mansuy-Schlick V,Rossi E,Boyer-Guittaut M,Fraichard A,Jouvenot M

更新日期：2008-05-19 00:00:00

abstract：:Computer-assisted morphometrics were used to characterize mature somatodendritic architecture in Golgi-stained neurons of the entopeduncular nucleus (EN) of the adult cat. Only one form of adult EN neuron was apparent and characterized by common features including: relatively large conical somata, long aspiny and mode...

journal_title：Brain research

authors： Dvergsten CL,Hull CD,Levine MS,Adinolfi AM,Fisher RS,Buchwald NA

更新日期：1986-06-11 00:00:00

abstract：:Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain th...

journal_title：Brain research

authors： Savory J,Huang Y,Herman MM,Reyes MR,Wills MR

更新日期：1995-01-16 00:00:00

abstract：:To test the hypothesis that presence of metalloproteases (MMPs), their inhibitors (TIMPs) and their substrate laminin-5 differs between the ischemic core and the surrounding tissue, we examined the impact of middle cerebral artery occlusion/reperfusion (MCA:O/R) on these molecules in different regions of the infarct. ...

journal_title：Brain research

authors： Wagner S,Nagel S,Kluge B,Schwab S,Heiland S,Koziol J,Gardner H,Hacke W

更新日期：2003-09-12 00:00:00

abstract：:The participation of amygdaloid and striatal structures in the various signs of morphine withdrawal syndrome (MWS) has been investigated using two complementary approaches: intracerebral application of naloxone in various nuclei of dependent rats and effects of various lesions and transections on systemically induced ...

journal_title：Brain research

authors： Calvino B,Lagowska J,Ben-Ari Y

更新日期：1979-11-09 00:00:00

abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...

journal_title：Brain research

authors： Araujo BH,Torres LB,Cossa AC,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2010-06-04 00:00:00

abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...

journal_title：Brain research

authors： Day TA,Sibbald JR,Smith DW

更新日期：1992-10-30 00:00:00

abstract：:The striatum has nearly equal numbers of striatonigral and striatopallidal projection neurons. All are GABAergic and inhibitory, but they lie in separate neuronal circuits ('direct' and 'indirect', respectively) that appear to exert opposite effects on movement. Methods are needed to evaluate the function of each circ...

journal_title：Brain research

authors： Santiago MP,Potter LT

更新日期：2001-03-09 00:00:00

abstract：:The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...

journal_title：Brain research

authors： Xiao H,Zhai DX,Yan BB,Wang JH,Xu WS,Wang GY,Bai SS,Kong QF,Sun B,Wang DD,Jin DJ,Li HL

更新日期：2009-05-19 00:00:00

abstract：:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...

journal_title：Brain research

authors： Beczkowska IW,Bodnar RJ

更新日期：1991-05-03 00:00:00

abstract：:Myelin of several Caudata (Urodela) species appears to be unique in the fact that it lacks hydroxycerebrosides and hydroxysulfatides although it contains their non-hydroxy counterparts. Comparison of the nerve conduction velocities in the Urodeles Necturus (salamander) and Notophthalmus (newt) with that in a reptile, ...

journal_title：Brain research

authors： Ki PF,Kishimoto Y,Lattman EE,Stanley EF,Griffin JW

更新日期：1985-10-14 00:00:00

abstract：:Methamphetamine (METH) is one of the most commonly abused psychostimulant, and is known to induce dopaminergic neurotoxicity by generating oxidative stress and free radicals. In the present study we investigated the effects of METH on egr-1 and c-fos immediate early gene induction in different regions of mouse brain, ...

journal_title：Brain research

authors： Thiriet N,Zwiller J,Ali SF

更新日期：2001-11-16 00:00:00

abstract：:The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (G...

journal_title：Brain research

authors： Khan M,Kumar P,Qiao F,Islam SMT,Singh AK,Won JS,Feng W,Singh I

更新日期：2020-08-15 00:00:00

abstract：:In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease ...

journal_title：Brain research

authors： Radu D,Brodin E,Weber G,Lindefors N

更新日期：2001-07-27 00:00:00

abstract：:Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...

journal_title：Brain research

authors： Murakami K,Suzuki M,Suzuki N,Hamajo K,Tsukamoto T,Shimojo M

更新日期：2013-08-14 00:00:00

abstract：:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...

journal_title：Brain research

authors： Tanifuji M,Yamanaka A,Sunaba R,Terakawa S,Toyama K

更新日期：1996-10-28 00:00:00

abstract：:The aim of this work was to study whether the vestibular afferent fibers establish direct connections with the motoneurons of glossopharyngeal and vagus nerves of the frog, Rana esculenta. In anaesthetized animals the vestibulocochlear nerve and the common root of glossopharyngeal-vagus and accessory (IX-X-XI) nerves ...

journal_title：Brain research

authors： Deák A,Bácskai T,Veress G,Matesz C

更新日期：2009-08-25 00:00:00

abstract：:The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored the possible underlying mechanism by examining metallothionein (MT)-1 and -2 induction in vivo. Cilostazol (30 mg/kg) was intraperitoneally administered at 12 h...

journal_title：Brain research

authors： Wakida K,Morimoto N,Shimazawa M,Hozumi I,Nagase H,Inuzuka T,Hara H

更新日期：2006-10-20 00:00:00

abstract：:Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the ph...

journal_title：Brain research

authors： Alberi S,Dubois-Dauphin M,Dreifuss JJ,Raggenbass M

更新日期：1993-10-08 00:00:00

abstract：:The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...

journal_title：Brain research

authors： Griffith WH,Taylor L

更新日期：1988-11-22 00:00:00

abstract：:We examined regional cerebral metabolic rates for glucose (rCMRglc) and brain incorporation coefficients (k*) of each of three intravenously infused fatty acid radiotracers, [9,10-(3H)]palmitate ([3H]PAM), [1-(14C)]arachidonate ([14C]AA) and [1-(14C)]docosahe-xaenoate ([14C]DHA), in awake rats fully kindled by once-da...

journal_title：Brain research

authors： Arai T,Jones CR,Rapoport SI,Weiss SR

更新日期：1996-12-16 00:00:00

abstract：:Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the c...

journal_title：Brain research

authors： Kalivas PW,Gau BA,Nemeroff CB,Prange AJ Jr

更新日期：1982-07-15 00:00:00