Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits.


:Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain the NFD. Dephosphorylation markedly reduces the positivity of AT8. Using PLP-fixed tissue, monoclonal antibody Tau-1 also immunostains aluminum-induced NFD.


Brain Res


Brain research


Savory J,Huang Y,Herman MM,Reyes MR,Wills MR




Has Abstract


1995-01-16 00:00:00














  • The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis.

    abstract::The neurophysiological effects of a novel, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester), CGP 39551, on the high pressure neurological syndrome (HPNS) were investigated in the non-human primate Papio anubis. Six animals wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pearce PC,Halsey MJ,Maclean CJ,Ward EM,Pearson J,Henley M,Meldrum BS

    更新日期:1993-09-17 00:00:00

  • Increased excitability and reduced intracortical inhibition in the ipsilateral primary motor cortex during a fine-motor manipulation task.

    abstract::The effects of a sensorimotor task on ipsilateral primary motor cortex (ipsi-M1) excitability mediated via the transcallosal pathway, including the changes in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were examined in ten right-handed subjects. Transcranial magnetic stimulati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morishita T,Ninomiya M,Uehara K,Funase K

    更新日期:2011-01-31 00:00:00

  • Membrane-delimited proteolytic regulation of opioid receptors.

    abstract::Prolonged exposure of opioid receptors to agonists leads to their regulation by the classical process of clathrin-dependent internalization, followed by their intracellular degradation (down regulation). We have previously shown that the opioid agonist etorphine induced an additional process of down regulation of mu-o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kaplan E,Binyaminy B,Gafni M,Keren O,Sarne Y

    更新日期:2011-04-22 00:00:00

  • Cholinergic activation of medial pontine reticular formation neurons in vitro.

    abstract::Direct microinjection of cholinergic compounds into pontine reticular formation furnishes an excellent phenomenological model of the rapid eye movement phase of sleep (REM), but the mechanisms underlying this effect and whether they mimic the cellular events of natural REM remain unknown. Data presented here from intr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Greene RW,Gerber U,McCarley RW

    更新日期:1989-01-02 00:00:00

  • Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair.

    abstract::A basic experiment of peripheral nerve regeneration using neuronal progenitor cells embedded in collagen gel was performed in a rat sciatic nerve defect. First, when neuronal progenitor cells derived from the fetal rat hippocampus were cultured in atelocollagen-containing medium, neurospheres positive for anti-nestin ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Murakami T,Fujimoto Y,Yasunaga Y,Ishida O,Tanaka N,Ikuta Y,Ochi M

    更新日期:2003-06-06 00:00:00

  • Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain.

    abstract::The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Weber YG,Geiger J,Kämpchen K,Landwehrmeyer B,Sommer C,Lerche H

    更新日期:2006-03-10 00:00:00

  • Long-term potentiation-induced synaptic changes in hippocampal dentate gyrus of rats with an inborn low or high learning capacity.

    abstract::Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gómez RA,Pozzo Miller LD,Aoki A,Ramírez OA

    更新日期:1990-12-24 00:00:00

  • Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia.

    abstract::Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present stud...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen L

    更新日期:2006-07-07 00:00:00

  • Transient elevation of intrasynaptosomal free calcium by putrescine.

    abstract::The role of polyamines in the regulation of free intrasynaptosomal Ca2+, [Ca2+]i was studied. After preincubation of rat brain synaptosomes with 5 mM difluormethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the K+-induced increase of [Ca2+]i was 33% less than that in non-treated synaptosome...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Komulainen H,Bondy SC

    更新日期:1987-01-13 00:00:00

  • Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.

    abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hand TH,Koob GF,Stinus L,Le Moal M

    更新日期:1988-12-06 00:00:00

  • Involvement of the nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway in the antihyperalgesic effects of bovine lactoferrin in a model of neuropathic pain.

    abstract::The possible involvement of the nitric oxide (NO)-cyclic GMP (cGMP)-protein kinase G (PKG) pathway on bovine lactoferrin (BLF)-induced spinal antihyperalgesic activity was elucidated in sciatic nerve injured rats. Intrathecal BLF reduced thermal hyperalgesia in a dose-dependent manner. Pretreatment with NG-L-nitro-arg...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang J,Zhang LC,Lv YW,Ji Y,Yan XJ,Xue JP

    更新日期:2008-05-13 00:00:00

  • Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment.

    abstract::Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunore...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Inoue T,Tsui J,Wong N,Wong SY,Suzuki F,Kwok YN

    更新日期:1999-05-01 00:00:00

  • Differences in forebrain androgen receptor expression in winners and losers of male anole aggressive interactions.

    abstract::Size matched male green anoles (Anolis carolinensis) were paired in a neutral setting and allowed to engage in aggressive displays. Winners and losers were apparent in each pair within 90min, resulting in stable dominant/subordinate dyads. Androgen receptor (AR) expression was assessed at three time points after the i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hattori T,Wilczynski W

    更新日期:2014-09-25 00:00:00

  • The role of angiotensin II in regulation of cerebrospinal fluid formation in rabbits.

    abstract::The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. CSF production was measured by the ventriculo-cisternal perfusion method with Blue dextran 2000 used as an indicat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chodobski A,Szmydynger-Chodobska J,Segal MB,McPherson IA

    更新日期:1992-10-23 00:00:00

  • Partial antagonism of 8-OH-DPAT'S effects on male rat sexual behavior with a D2, but not a 5-HT1A, antagonist.

    abstract::The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matuszewich L,Lorrain DS,Trujillo R,Dominguez J,Putnam SK,Hull EM

    更新日期:1999-02-27 00:00:00

  • Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia.

    abstract::To test the hypothesis that presence of metalloproteases (MMPs), their inhibitors (TIMPs) and their substrate laminin-5 differs between the ischemic core and the surrounding tissue, we examined the impact of middle cerebral artery occlusion/reperfusion (MCA:O/R) on these molecules in different regions of the infarct. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wagner S,Nagel S,Kluge B,Schwab S,Heiland S,Koziol J,Gardner H,Hacke W

    更新日期:2003-09-12 00:00:00

  • Acetylcholine-activated currents in mouse neuroblastoma cells.

    abstract::The nicotine and muscarinic responses of differentiated mouse neuroblastoma cells from the clonal line N1E 115 to applied cholinergic agents were recorded using single channel and whole cell patch clamp techniques. An inward macroscopic current induced by acetylcholine (ACh) at the resting potential was blocked by cur...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takeda K,Shimahara T,Tauc L,Berwald-Netter Y

    更新日期:1986-11-19 00:00:00

  • Functional significance of the apamin-sensitive conductance in rat locus coeruleus neurons.

    abstract::The effects of apamin on rat locus coeruleus (LC) neurons were studied in a brain slice preparation with intracellular recording. Bath application of apamin (2-500 nM) reduced the amplitude of an intermediate component of the afterhyperpolarization (AHP) following single spontaneous action potentials, but did not chan...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Osmanović SS,Shefner SA,Brodie MS

    更新日期:1990-10-22 00:00:00

  • Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis.

    abstract::Orexin-A (OX-A) and -B (OX-B) peptides present in the hippocampus are considered to be exclusively contained in fibers arising from hypothalamus neurons, which were established as the only source of orexins (OXs). Because OX-A is known to exert excitatory actions in the hippocampus, we hypothesized that the level of O...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morales A,Bonnet C,Bourgoin N,Touvier T,Nadam J,Laglaine A,Navarro F,Moulin C,Georges B,Pequignot JM,Bezin L

    更新日期:2006-09-13 00:00:00

  • Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.

    abstract::Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Köhling R,Koch UR,Hagemann G,Redecker C,Straub H,Speckmann EJ

    更新日期:2003-06-13 00:00:00

  • Anxiety in Parkinson's disease: Abnormal resting activity and connectivity.

    abstract::Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Criaud M,Kim JH,Zurowski M,Lobaugh N,Chavez S,Houle S,Strafella AP

    更新日期:2021-02-15 00:00:00

  • The locus coeruleus of the Japanese monkey (Macaca fuscata) does not express mu-opioid receptor-like immunoreactivity.

    abstract::It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chen J,Koyama N,Kaneko T,Mizuno N

    更新日期:1997-05-02 00:00:00

  • Mesenchymal stem cells as cellular vectors for pediatric neurological disorders.

    abstract::Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Phinney DG,Isakova IA

    更新日期:2014-07-21 00:00:00

  • Ventral pontine catecholaminergic pathway mediates the vasopressin response to splanchnic osmostimulation in conscious rats.

    abstract::This study examines the role of catecholamines, cell bodies and fibers of passage within the subcoeruleus area (subLC) in the arginine vasopressin (AVP) response to splanchnic osmotic stimulation and hemorrhage. Bilateral chemical lesions were induced into the subLC, approximately 1 mm ventral to the locus coeruleus (...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: King MS,Baertschi AJ

    更新日期:1992-05-15 00:00:00

  • Effects of intraventricular substantia nigra allografts as a function of donor age.

    abstract::Transplantation of fetal substantia nigra into the brain can alleviate some of the manifestations of animal models of Parkinson's disease. The purpose of the present experiment was to determine the optimal embryonic donor age for solid tissue substantia nigra grafts. Rats with unilateral substantia nigra lesions were ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Simonds GR,Freed WJ

    更新日期:1990-10-15 00:00:00

  • Massive retinotectal projection in rats.

    abstract::Retinal ganglion cells were labeled with horseradish peroxidase injected into the superior colliculus of normal pigmented rats. It is shown that virtually all ganglion cells with crossed axons project to the tectum, thus including all cell types described so far in the rat. The results contrast with the conclusion tha...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Linden R,Perry VH

    更新日期:1983-08-01 00:00:00

  • Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.

    abstract::Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hayakawa T,Chang MC,Bell JM,Seeman R,Rapoport SI,Appel NM

    更新日期:1998-10-05 00:00:00

  • Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat.

    abstract::The central nucleus of the amygdala (CEA) is selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response during conditioned, stressful environmental challenges. Vasopressinergic mechanisms in the brain seem to play a role in these stress responses. The eff...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Roozendaal B,Wiersma A,Driscoll P,Koolhaas JM,Bohus B

    更新日期:1992-11-20 00:00:00

  • Somatostatin-28-like immunoreactivity in the rat olfactory bulb.

    abstract::Using an immunoperoxidase technique, somatostatin-28-like immunoreactive (LIR) neurons were observed in the main and accessory olfactory bulb (MOB and AOB) of adult rats. In the MOB, a restricted population of periglomerular cells in the glomerular layer, some superficial short-axon cells in the juxtaglomerular layer,...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takami S,el-Hawary MH,Graziadei PP

    更新日期:1990-09-03 00:00:00

  • Do CNS anlagen have plasticity in differentiation? Analysis in quail-chick chimera.

    abstract::Heterotopic transplantations of brain vesicles of a quail embryo into a chick embryo were carried out in order to elucidate if CNS anlagen have plasticity in differentiation at the 7-10 somite stage. Quail cells are distinguished from chick cells due to the difference in nuclear morphology. The prosencephalon did not ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakamura H

    更新日期:1990-03-12 00:00:00