Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits.

Abstract:

:Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain the NFD. Dephosphorylation markedly reduces the positivity of AT8. Using PLP-fixed tissue, monoclonal antibody Tau-1 also immunostains aluminum-induced NFD.

journal_name

Brain Res

journal_title

Brain research

authors

Savory J,Huang Y,Herman MM,Reyes MR,Wills MR

doi

10.1016/0006-8993(94)01297-u

subject

Has Abstract

pub_date

1995-01-16 00:00:00

pages

325-9

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)01297-U

journal_volume

669

pub_type

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