Abstract:
:Electrophysiological studies have suggested that the excitatory actions of opioids in the hippocampal formation are mediated by inhibition of interneurons containing GABA; however, an anatomical basis for this interaction has never been established. Thus, we sought to determine the relationship between leu-enkephalin (LE)-containing axon terminals and GABAergic neurons using dual labeling immunohistochemistry and electron microscopy. In the CA1 region of the hippocampus, LE-labeled terminals (n = 99) were in direct contact with GABA-labeled perikarya and dendrites (18%), and directly apposed to GABA-labeled axon terminals (14%). In the molecular layer of the dentate gyrus, LE-containing terminals (n = 125) occasionally apposed GABA-containing terminals (8%). In the hilus of the dentate gyrus, LE-containing terminals (n = 165) often contacted GABA-containing perikarya and dendrites (39%), but rarely apposed GABA-containing terminals (3%). In the CA3 region of the hippocampus, only a few LE-labeled mossy fiber boutons (n = 102) contacted the shafts of GABA-labeled dendrites (4%). The results demonstrate that leu-enkephalin-containing terminals have a different anatomical relationship with GABA-containing profiles in each subregion of the hippocampal formation. In the CA1 region of the hippocampus, the data support the numerous electrophysiological studies indicating that LE functions in modulating inhibitory GABAergic neurons by both pre- and postsynaptic mechanisms. In the outer molecular layer of the dentate gyrus the localization suggests some presynaptic regulation of GABAergic terminals. In the hilus of the dentate gyrus, the study also supports the contention that LE may have an important role in regulating inhibition of GABA-containing neurons. In comparison, in the CA3 region of the hippocampus, LE may have a more limited role in regulating GABAergic inhibition by direct association.
journal_name
Brain Resjournal_title
Brain researchauthors
Commons KG,Milner TAdoi
10.1016/0006-8993(96)00236-3subject
Has Abstractpub_date
1996-06-10 00:00:00pages
1-15issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(96)00236-3journal_volume
724pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2007.06.097
更新日期:2008-04-02 00:00:00
abstract::Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01364-n
更新日期:1995-02-13 00:00:00
abstract::The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.023
更新日期:2006-03-10 00:00:00
abstract::Attachment, growth and morphological differentiation of isolated adult rat oligodendrocytes cultured on a naturally produced basement membrane-like extracellular matrix (ECM) occurred much faster than on poly-L-lysine (PLL) coated tissue culture dishes. In each individual trial the cells cultured on ECM exhibited, wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91049-1
更新日期:1983-05-09 00:00:00
abstract::To clarify the effects of arachidonic acid (AA) and its metabolites on desensitization of nicotinic acetylcholine (ACh) receptor channel in mouse skeletal muscle cells, we investigated the time-dependent decrease in the channel opening frequency of ACh (1 microM)-activated channel currents by the cell-attached patch c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02206-4
更新日期:2000-01-03 00:00:00
abstract::Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90946-8
更新日期:1988-03-22 00:00:00
abstract::We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00876-1
更新日期:1996-11-18 00:00:00
abstract::Neural transplantation is a promising approach for treating neurodegenerative disease. Neural stem/progenitor cells (NPCs) are self-renewing and multipotent and thus are good candidates for donor cells when they have been clearly defined to differentiate into neurons. As neuronal differentiation follows cell cycle exi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.046
更新日期:2006-05-30 00:00:00
abstract::Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91249-1
更新日期:1994-02-21 00:00:00
abstract::In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation in the dorsolateral part of the periaqueductal grey matter (PAG; 10 s trains of 1 ms pulses at 80 Hz, 40-80 microA) evoked a pressor response accompanied by tachycardia. Both components of the response were attenuated following microinjection o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90702-1
更新日期:1994-07-18 00:00:00
abstract::Experiments were performed in ambulating decerebrate ferrets to examine the activity of up to 6 simultaneously recorded Purkinje cells oriented sagittally during unperturbed and perturbed locomotion using a new analytical technique, the real-time postsynaptic response (RTPR), which permits a trial-by-trial assessment ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91646-x
更新日期:1986-02-19 00:00:00
abstract::Our research group recently presented the distribution of thyrotropin-releasing hormone (TRH) in the chicken brain. In this study we measured somatostatin (SRIH) concentrations in different brain parts and nuclei. The distribution of SRIH and TRH in peripheral tissues was also studied. Although the highest SRIH conten...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02550-6
更新日期:2000-08-11 00:00:00
abstract::The intracerebroventricular injection (1 microgram) of murine corticotropin-releasing factor (r-CRF) to rats after 72 h of sleep deprivation markedly postponed the sleep onset, reduced slow wave sleep and prolonged the duration of paradoxical sleep (PS) episodes. Moreover, CRF is-to our knowledge-the first compound to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90614-h
更新日期:1990-05-07 00:00:00
abstract::Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90147-1
更新日期:1986-02-01 00:00:00
abstract::Cytosolic phospholipase A2 (cPLA2) catalyzes the selective release of arachidonic acid from the sn-2 position of membrane phospholipids and has been suggested as an effector in the receptor-mediated release of arachidonic acid in signal transduction. The potential role of cPLA2 as an effector in muscarinic acetylcholi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00806-3
更新日期:1998-10-26 00:00:00
abstract::Electrolytic lesions were placed in the medial cerebellar nucleus in tree shrews (Tupaia glis) or in fibers issuing from this nucleus. Brains and spinal cords were processed according to Fink-Heimer procedure following survival times of 2-7 days. In control animals lesions were placed in the cerebellar cortex and, in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91044-8
更新日期:1979-08-10 00:00:00
abstract::The climbing fiber input to the cerebellar cortex was destroyed using both electrolytic and chemical (3-acetylpyridine) lesions. The long-term effects of climbing fiber deafferentation on the ansiform lobule of weanling and adult rats were examined at both the light and electron microscopic levels. Image analysis of G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90022-3
更新日期:1986-09-24 00:00:00
abstract::The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 blocks the ability of D-methamphetamine (MA) to deplete striatal dopamine (DA). We now report that MK-801 attenuates decreases in serotonin (5-HT) concentration induced by MA and two other amphetamine analogues, 3,4-methylenedioxymethamphetamin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91460-v
更新日期:1992-11-06 00:00:00
abstract::Locally applied ciliary neurotrophic factor (CNTF) has a powerful effect on retrograde axonal reaction following facial nerve crush in neonatal rats. We examined whether it also exerts a strong effect on retrograde axonal reaction in young adult rats when administered subcutaneously. The dose was 1 mg/kg body weight, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01512-4
更新日期:1996-04-22 00:00:00
abstract::Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.039
更新日期:2005-03-21 00:00:00
abstract::The effect of unilateral basilar papilla removal on glucose uptake in the 2nd and 3rd order auditory nuclei in the chick's brain stem, nucleus magnocellularis and nucleus laminaris, respectively, was examined with [3H]2-deoxy-D-glucose (2-DG) autoradiography. The tissue was processed according to a thaw-mount techniqu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90715-5
更新日期:1980-08-25 00:00:00
abstract::Measurements of extracellular Ca2+ and K+ activities [( Ca2+]o, [K+]o) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]o of 0.035 +/- 0.17 mM (mean +/- S.D.; n = 17) and a biphasic change in [K+]o which consisted of an incre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91186-4
更新日期:1989-03-20 00:00:00
abstract::Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03387-0
更新日期:2003-11-14 00:00:00
abstract::Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00150-4
更新日期:1998-05-11 00:00:00
abstract::Amyloid-beta protein (A beta) deposition in the cerebral vascular walls is one of the key features of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). A beta(1-40) carrying the 'Dutch' mutation (HCHWA-D A beta(1-40)) induces pronounced degeneration of cultured human brain p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03218-3
更新日期:2002-10-11 00:00:00
abstract::Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02361-2
更新日期:2002-04-26 00:00:00
abstract::Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.09.032
更新日期:2012-11-27 00:00:00
abstract::The aim of the present study was to show that space perception depends on sensori-motor experience. We induced spatial biases by a non-conflictual lateralized sensori-motor task on twenty seven right-handed healthy volunteers (left-to-right readers). After a pre-test and before a post-test, which assessed visuo-motor ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.021
更新日期:2008-06-12 00:00:00
abstract::Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00076-6
更新日期:1998-03-30 00:00:00
abstract:PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.041
更新日期:2016-10-01 00:00:00