Abstract：
:Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward currents under K(+)-free conditions at a holding potential of -70 mV. The currents were dependent on extracellular Na+ concentration, and were never reversed within the range of membrane potentials tested (-130 to 30 mV). These results indicate that accumulation of intracellular cAMP induces Na(+)-dependent inward currents in frog motoneurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Adachi S,Oka J,Nagao T,Fukuda Hdoi
10.1016/0006-8993(92)90787-asubject
Has Abstractpub_date
1992-02-28 00:00:00pages
349-52issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90787-Ajournal_volume
573pub_type
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