Abstract：
:Trigeminal hyperalgesia frequently appears in diabetic neuralgia altering the transmission of orofacial sensory information. This study was designed to explore the effects of trigeminal hyperalgesia in streptozotocin-induced diabetes monitoring the expression of nitric oxide synthase in the trigeminal ganglion cells. The threshold to heat noxious stimuli decreased in diabetic animals. The number of NADPH-diaphorase (NADPH-d)-positive neurons significantly decreased in the diabetic rats compared with controls. Insulin treatment prevented the decreased nociceptive threshold and reduction of the number of NADPH-d-positive neurons. These findings point out that there is a relationship between the trigeminal nociceptive perception and NADPH-d neuronal expression suggesting that NO may play a role in the pathogenesis of trigeminal sensory neuropathy.
journal_name
Brain Resjournal_title
Brain researchauthors
Rodella L,Rezzani R,Corsetti G,Bianchi Rdoi
10.1016/s0006-8993(00)02235-6subject
Has Abstractpub_date
2000-05-19 00:00:00pages
112-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02235-6journal_volume
865pub_type
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