Abstract：
:Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Following an initial round of behavioral testing, all mice were housed in standard cages and retested. Enriched cage mice (both ectopic and non-ectopic) showed increased activity, greater speed, and enhanced learning scores across a variety of tests. Additionally, prior test experience itself had significant positive effects on Hebb-Williams maze learning. The presence of ectopias resulted in better Morris maze learning for standard cage reared mice. Further, ectopic mice, regardless of their housing condition, showed better long-term retention in the Morris maze than did their non-ectopic counterparts. These findings show that abnormalities in corticogenesis need not always result in functional deficit.
journal_name
Brain Resjournal_title
Brain researchauthors
Boehm GW,Sherman GF,Hoplight BJ 2nd,Hyde LA,Waters NS,Bradway DM,Galaburda AM,Denenberg VHsubject
Has Abstractpub_date
1996-07-08 00:00:00pages
11-22issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00299-5journal_volume
726pub_type
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