Abstract：
:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both kainate and glutamate exerted similar behavioral effects from postnatal day 15 onwards. No correlation appears between kainate/glutamate-induced behavioral changes and their neurodegenerative potency.
journal_name
Brain Resjournal_title
Brain researchauthors
Wolf G,Keilhoff Gdoi
10.1016/0165-3806(84)90004-xsubject
Has Abstractpub_date
1984-05-01 00:00:00pages
15-21issue
1eissn
0006-8993issn
1872-6240journal_volume
316pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:An investigation of reflex responses of leg muscles to sural stimulation during stepping was performed on human subjects. Non-noxious electrical stimulation applied during the swing phase or the latter half of the stance phase produced a mixed increase and decrease of EMG activity in the hamstring muscles. No response...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90123-3
更新日期：1983-12-12 00:00:00
abstract：:Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03387-0
更新日期：2003-11-14 00:00:00
abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.023
更新日期：2019-07-01 00:00:00
abstract：:Brainstem noradrenergic neurons located in the A5, A6, and A7 catecholamine cell groups provide the entire noradrenergic innervation of the spinal cord. We have previously demonstrated that noradrenergic neurons in the A6 and A7 cell groups innervate the ventral and dorsal horns, respectively. Since the specific spina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90210-e
更新日期：1993-07-09 00:00:00
abstract：:The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01372-o
更新日期：1995-02-06 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute to epileptic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.038
更新日期：2005-07-19 00:00:00
abstract：:Using nerve growth factor (NGF), anti-NGF sera and dissociated neonatal mouse dorsal root ganglionic neurons we present a microculture assay methodology for (1) the titration of neurotrophic factor (NTF) activity in monolayer culture, (2) the titration of NTF antibodies which 'block' NTF biological activity, (3) the t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90408-x
更新日期：1981-12-28 00:00:00
abstract：:The effects of neonatal dopamine depletion on activity levels and locomotor patterns were tested in rats at 4 months of age. Measurements were taken using an activity pattern monitor. The lesioned group was significantly hypoactive in comparison to the control animals during the initial exposures to the monitor. Exami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91637-3
更新日期：1994-05-09 00:00:00
abstract：:Reward deficit, expressed as anhedonia, is one of the major symptoms associated with neuropsychiatric disorders, but the underlying maladaptations have not been understood. Herein, we test the hypothesis that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) may participate in the process. The stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146595
更新日期：2020-02-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:An in vitro method was developed to separately visualize dopaminergic, noradrenergic and serotoninergic terminals in the cerebral, hippocampal and cerebellar cortices of the rat, by means of the glyoxylic histochemical fluorescence method. Animals were pretreated with alpha-methylparatyrosine to deplete catecholamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90770-9
更新日期：1978-05-19 00:00:00
abstract：:Because brainstem auditory evoked potentials (BAEPs) are frequently recorded in anesthetized animals and humans, it is important to become familiar with the effects on the BAEP of drugs used during anesthesia, including pre-anesthetics. The dose-dependent and stimulus intensity-dependent effects on the BAEP of a pre-a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90221-1
更新日期：1988-07-26 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) and the pineal body in 3 types of inherited hormone-deficient mice, the dw, lit and hyt mice were examined by morphological, morphometric and biochemical techniques. In the dw and lit mice the SCN was underdeveloped. In the ventral part of the SCN, where most of the retinal fibers app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90279-8
更新日期：1986-05-01 00:00:00
abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90046-0
更新日期：1985-02-11 00:00:00
abstract：INTRODUCTION:Apathy is the most common neuropsychiatric syndrome in behavioral variant frontotemporal dementia (bvFTD), and encompasses cognitive, behavioral and affective symptoms. The neural basis of apathy in bvFTD is not completely understood. Previous neuroimaging studies have poorly considered executive impairmen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146799
更新日期：2020-06-15 00:00:00
abstract：:The stimulatory effect of insulin-like growth factor I (IGF-I) on myelin basic protein (MBP) expression, a parameter for oligodendrocyte development, is mediated by the MAPK and PI3K signaling pathways. We have previously shown that the second messenger cAMP inhibits IGF-I-induced MAPK activation as well as MBP expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.018
更新日期：2007-10-31 00:00:00
abstract：:Intrinsic versus extrinsic determinants of age-related alterations in hippocampal noradrenergic transmission were investigated using intraocular allografts in rats. Three groups of animals were examined: young hippocampal transplants in young hosts, old transplants in old hosts and young transplants in old hosts. Post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91507-2
更新日期：1989-01-30 00:00:00
abstract：:The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation, and specifically macrophage activation, likely plays a key role. Macrophages have the ability to promote the...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.12.045
更新日期：2015-09-04 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.058
更新日期：2010-01-14 00:00:00
abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90360-0
更新日期：1989-04-10 00:00:00
abstract：:We measured the uptake of a radiolabeled analogue of glucose ([3H]FDG) into muscles during treadmill walking so as to determine whether sensory deafferentation of a limb affects the muscles' metabolic response to the exercise. The muscles on the deafferented side took up less tracer than those in the intact side with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91526-4
更新日期：1985-02-18 00:00:00
abstract：:Electrolytic lesions were placed in the medial cerebellar nucleus in tree shrews (Tupaia glis) or in fibers issuing from this nucleus. Brains and spinal cords were processed according to Fink-Heimer procedure following survival times of 2-7 days. In control animals lesions were placed in the cerebellar cortex and, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91044-8
更新日期：1979-08-10 00:00:00
abstract：:We examined ethanol's interactions with serotonin (5-HT) receptor-mediated [3H]5-HT high-affinity uptake by adult rat forebrain synaptosomes. The serotonergic transport mechanism was chosen because ethanol consumption patterns can be manipulated by serotonin receptors and uptake blockers. We report that a dose of etha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90060-9
更新日期：1991-03-29 00:00:00
abstract：:We have shown previously that progesterone linked with bovine serum albumin at position 3 of the progesterone molecule (P-3-BSA) was effective in modulating (both stimulating and inhibiting) amphetamine (AMPH)-evoked dopamine (DA) release in vitro from superfused corpus striatal (CS) tissue fragments of ovariectomized...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90395-c
更新日期：1991-01-04 00:00:00
abstract：:Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.013
更新日期：2013-01-23 00:00:00
abstract：:The analgesic effect of clonidine in spontaneously hypertensive rats (SHR) and in normotensive Sprague-Dawley (SD) rats was assessed by using the formalin pain test. The analgesic response of SD rats to low doses (15-60 micrograms/kg i.p.) but not to a high dose (150 micrograms/kg i.p.) of clonidine was inhibited by n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91630-2
更新日期：1989-02-13 00:00:00
abstract：:Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.073
更新日期：2009-09-08 00:00:00
abstract：:Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91526-x
更新日期：1986-12-10 00:00:00
abstract：:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91028-x
更新日期：1984-08-20 00:00:00
abstract：:The central melanocortin system plays a critical role in regulation of energy balance, including thermogenesis in brown adipose tissue (BAT). Activation of the hypothalamic melanocortin signaling stimulates sympathetically-mediated interscapular BAT (IBAT) thermogenesis. The rostral raphe pallidus (rRPa) and adjacent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.006
更新日期：2007-11-07 00:00:00
