Nitric oxide-mediated cGMP synthesis in Helix neural ganglia.

abstract：:Although transsynaptic tracing with peripheral injection of pseudorabies virus (PRV) has been extensively characterized, several methodological issues related to central application of this tracer have not been addressed. In the present study, we addressed the following three issues by using microinjection of a cockta...

journal_title：Brain research

authors： Chen S,Yang M,Miselis RR,Aston-Jones G

更新日期：1999-08-14 00:00:00

abstract：:Opiate regulation of the nuclear proto-oncogene c-fos was studied in the locus coeruleus (LC) and other regions of rat brain by immunoblotting, northern blotting, and in situ hybridization procedures. Precipitation of opiate withdrawal in rats, which is known to increase LC firing rates 4-fold, led to a two- to three-...

journal_title：Brain research

authors： Hayward MD,Duman RS,Nestler EJ

更新日期：1990-08-20 00:00:00

abstract：:Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the...

journal_title：Brain research

authors： Hull EM,Weber MS,Eaton RC,Dua R,Markowski VP,Lumley L,Moses J

更新日期：1991-07-19 00:00:00

abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...

journal_title：Brain research

authors： Aihara H,Okada Y,Tamaki N

更新日期：2001-03-02 00:00:00

abstract：:Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...

journal_title：Brain research

authors： Chang HM,Ling EA,Lue JH,Wen CY,Shieh JY

更新日期：2000-08-11 00:00:00

abstract：:Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism. In this study, AMP deaminase and ADA activities of rat liver, neocortex, cerebellum, striatum and...

journal_title：Brain research

authors： Kaminsky Y,Kosenko E

更新日期：2010-01-22 00:00:00

abstract：:In anesthetized rats, out of 48 paraventricular (PaV) and 19 periventricular (PeV) neurosecretory cells, 12 PaV and 6 PeV cells increased and 10 PaV cells decreased the electrical activities statically in response to preoptic and anterior hypothalamic warming. Four PaV and 2 PeV cells responded dynamically to the ther...

journal_title：Brain research

authors： Matsumura K,Nakayama T,Ishikawa Y

更新日期：1983-12-19 00:00:00

abstract：:Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...

journal_title：Brain research

authors： Racine RJ,Paxinos G,Mosher JM,Kairiss EW

更新日期：1988-06-28 00:00:00

abstract：:Experiments were carried out on UC-11MG human astrocytoma cells, a continuous cell line that expresses a broad range of the biochemical and electrophysiological properties found in well-differentiated astrocytes. Because of a number of recent reports that astrocytes may express receptors for a variety of neuro-active ...

journal_title：Brain research

authors： Lucherini MJ,Gruenstein E

更新日期：1992-10-02 00:00:00

abstract：:The effects of a sensorimotor task on ipsilateral primary motor cortex (ipsi-M1) excitability mediated via the transcallosal pathway, including the changes in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were examined in ten right-handed subjects. Transcranial magnetic stimulati...

journal_title：Brain research

authors： Morishita T,Ninomiya M,Uehara K,Funase K

更新日期：2011-01-31 00:00:00

abstract：:Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunof...

journal_title：Brain research

authors： Ichikawa H,Sugimoto T

更新日期：2003-06-06 00:00:00

abstract：:Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to th...

journal_title：Brain research

authors： Kanda H,Kobayashi K,Yamanaka H,Okubo M,Dai Y,Noguchi K

更新日期：2021-01-01 00:00:00

abstract：:Cortical stimulation has been demonstrated to alleviate certain pain conditions. The aim of this study was to determine the responses of the spinal cord dorsal horn neurons to stimulation of the primary somatosensory cortex (SSC). We hypothesized that direct stimulation of the SSC will inhibit the activity of spinal d...

journal_title：Brain research

authors： Senapati AK,Huntington PJ,LaGraize SC,Wilson HD,Fuchs PN,Peng YB

更新日期：2005-09-28 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...

journal_title：Brain research

authors： Gao H,Han Z,Bai R,Huang S,Ge X,Chen F,Lei P

更新日期：2017-02-15 00:00:00

abstract：:Swimmeret mechanostimulation initiates an abdominal extension program which includes flexion inhibition. Agonists and antagonists were used to examine the GABAergic nature of inhibitory responses recorded intracellularly from a flexion producing interneuron (FPI 303) and flexor motor neuron (f3) pair, and extracellula...

journal_title：Brain research

authors： Kotak VC,Page CH

更新日期：1991-01-11 00:00:00

abstract：:Recent researches suggest that autophagic degradation declines with age, and this leads to an accumulation of damage that contributes to age-related cellular dysfunction. Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) shows therapeutic potential for cerebral ischemia in young-adult animals. This study inve...

journal_title：Brain research

authors： Wang P,Lu Y,Han D,Wang P,Ren L,Bi J,Liang J

更新日期：2019-11-15 00:00:00

abstract：:We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...

journal_title：Brain research

authors： Wohltmann M,Roth BL,Coscia CJ

更新日期：1982-04-01 00:00:00

abstract：:In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...

journal_title：Brain research

authors： Tatetsu M,Kim J,Kina S,Sunakawa H,Takayama C

更新日期：2012-03-29 00:00:00

abstract：:To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...

journal_title：Brain research

authors： Overstreet DH,Russell RW,Crocker AD,Schiller GD

更新日期：1984-03-05 00:00:00

abstract：:Depolarization by K+ (50 mM) of cultured chick retina cells released 1.14 +/- 0.28% of the accumulated [3H] gamma-aminobutyric acid (GABA) in the absence of Ca2+, but when 1.0 mM Ca2+ was present, the internal free calcium ion concentration [Ca2+]i rose by about 750 nM and the [3H]GABA release about doubled to a value...

journal_title：Brain research

authors： Duarte CB,Ferreira IL,Santos PF,Oliveira CR,Carvalho AP

更新日期：1992-09-18 00:00:00

abstract：:The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...

journal_title：Brain research

authors： Nabeshima T,Matsuno K,Kameyama T

更新日期：1985-09-16 00:00:00

abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...

journal_title：Brain research

authors： Heckroth JA,Abbott LC

更新日期：1994-09-26 00:00:00

abstract：:The hindpaw was partially denervated by the tibial nerve transection in adult rats. At post-transection intervals varying from 2 to 168 days, the hindpaw was stimulated bilaterally by subcutaneous injection of formalin. The excitability of dorsal horn neurons was expressed as the percentage ratio of the number of form...

journal_title：Brain research

authors： Sugimoto T,Ichikawa H,Mitani S,Hitsu A,Nakago T

更新日期：1994-04-11 00:00:00

abstract：:This study examined the behavioral effects of agents active at the gamma-aminobutyric acid (GABA(A)) receptor complex in the mouse staircase paradigm. The neuroactivesteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were compared with the benzodiazepine agonist clonazepam, the non-benz...

journal_title：Brain research

authors： Weizman R,Paz L,Peter Y,Toren P,Pick CG

更新日期：2001-05-18 00:00:00

abstract：:Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...

journal_title：Brain research

authors： Bates CA,Meyer RL

更新日期：1996-04-01 00:00:00

abstract：:Intracellular recordings from locus coeruleus neurons grown in explant cultures reveal age-related differences in the responses to iontophoretically applied noradrenaline. Cells grown in culture for more than 26 days exhibit a simple hyperpolarizing response while cells cultured for less than 26 days often have biphas...

journal_title：Brain research

authors： Finlayson PG,Marshall KC

更新日期：1986-03-01 00:00:00

abstract：:To examine the role played by the basal forebrain cholinergic system in cortical activation, neuronal activity was investigated in the globus pallidus and substantia innominata of urethane-anaesthetized rats during large cortical slow waves and spontaneous or elicited low voltage fast activity. An effort was made to i...

journal_title：Brain research

authors： Détári L,Vanderwolf CH

更新日期：1987-12-22 00:00:00

abstract：:Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...

journal_title：Brain research

authors： Kalra PS,Norlin M,Kalra SP

更新日期：1995-12-24 00:00:00

abstract：:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...

journal_title：Brain research

authors： Kass IS,Abramowicz AE,Cottrell JE,Amorim P,Chambers G

更新日期：1994-01-07 00:00:00

abstract：:Hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the paraventricular nucleus of the hypothalamus (PVN). These neurons are well-known to be stimulated by cold exposure through activation of ascending brainstem pa...

journal_title：Brain research

authors： Füzesi T,Wittmann G,Lechan RM,Liposits Z,Fekete C

更新日期：2009-10-19 00:00:00