Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia.

abstract：:In the present study, we performed immunohistochemical studies to investigate the changes of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation. In contrast to the controls, a high density of Bcl-2-IR astrocytes were detected all around the gray matter of the spina...

journal_title：Brain research

authors： Shin CM,Chung YH,Kim MJ,Shin DH,Kim YS,Gurney ME,Lee KW,Cha CI

更新日期：2000-12-29 00:00:00

abstract：:We investigated the brain-stem pathway(s) by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the palate contralateral to the stimulated side. This occurs in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized wi...

journal_title：Brain research

authors： Mizuta K,Izumi H

更新日期：2004-09-10 00:00:00

abstract：:Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...

journal_title：Brain research

authors： Ling GY,Cao WH,Onodera M,Ju KH,Kurihara H,Kurihara Y,Yazaki Y,Kumada M,Fukuda Y,Kuwaki T

更新日期：1998-10-19 00:00:00

abstract：:The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...

journal_title：Brain research

authors： Hozumi I,Inuzuka T,Hiraiwa M,Uchida Y,Anezaki T,Ishiguro H,Kobayashi H,Uda Y,Miyatake T,Tsuji S

更新日期：1995-08-07 00:00:00

abstract：:The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored the possible underlying mechanism by examining metallothionein (MT)-1 and -2 induction in vivo. Cilostazol (30 mg/kg) was intraperitoneally administered at 12 h...

journal_title：Brain research

authors： Wakida K,Morimoto N,Shimazawa M,Hozumi I,Nagase H,Inuzuka T,Hara H

更新日期：2006-10-20 00:00:00

abstract：:The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...

journal_title：Brain research

authors： Kashihara K,Hamamura T,Okumura K,Otsuki S

更新日期：1990-09-24 00:00:00

abstract：:The modulation of tetrodotoxin-sensitive (TTX-S) and slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons by ATP was studied using the whole-cell patch-clamp method. The effects of ATP on two types of sodium currents were either stimulatory or inhibitory depending on the kinetic para...

journal_title：Brain research

authors： Joo Choi E,Hong MP,Kyoo Shin Y,Soo Lee C,Park M,Song JH

更新日期：2003-04-04 00:00:00

abstract：:Indirect immunofluorescence cytochemistry of ovine corticotropin releasing factor (oCRF) was performed by use of an antiserum raised against a conjugate of oCRF and bovine thyroglobulin. The staining intensity was quantitated by use of an automated microfluorimeter. In cryostat sections of formaldehyde fixed oCRF cont...

journal_title：Brain research

authors： Schipper J,Werkman TR,Tilders FJ

更新日期：1984-02-13 00:00:00

abstract：:Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...

journal_title：Brain research

authors： Oliveira LT,Leon GVO,Provance DW Jr,de Mello FG,Sorenson MM,Salerno VP

更新日期：2015-07-30 00:00:00

abstract：:Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was...

journal_title：Brain research

authors： Johnson EM Jr,Blumberg HM,Costrini NV,Bradshaw RA

更新日期：1979-12-14 00:00:00

abstract：:We investigated the effect of focal cerebral ischaemia on the activity and the affinity of the ouabain sites of Na+,K+-ATPase in the mouse. The Na+,K+-ATPase activity was decreased by 38% as early as 30 min following ischaemia. In the sham group, the dose-response curves for ouabain disclosed three inhibitory states w...

journal_title：Brain research

authors： Jamme I,Petit E,Gerbi A,Maixent JM,MacKenzie ET,Nouvelot A

更新日期：1997-11-07 00:00:00

abstract：:In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...

journal_title：Brain research

authors： Tatetsu M,Kim J,Kina S,Sunakawa H,Takayama C

更新日期：2012-03-29 00:00:00

abstract：:Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...

journal_title：Brain research

authors： Byrum CE,Stornetta R,Guyenet PG

更新日期：1984-06-11 00:00:00

abstract：:The role of the central noradrenergic system in the supraoptic neuroendocrine regulation was investigated using slices of the guinea pig hypothalamus. Noradrenaline produced a complex membrane effect comprising two distinct depolarizations: one, associated with a moderate increase in input resistance and resulting in ...

journal_title：Brain research

authors： Ogata N,Matsuo T

更新日期：1986-10-15 00:00:00

abstract：:The known neurochemical effect of most currently available antidepressants is the enhancement of the synaptic levels of monoamine neurotransmitters. However, the existence of other mechanisms has been suggested to justify the significant delay between the modulation of the monoaminergic system and the clinical effects...

journal_title：Brain research

authors： Cecconi D,Mion S,Astner H,Domenici E,Righetti PG,Carboni L

更新日期：2007-03-02 00:00:00

abstract：:The herpes virus suis has been used as a tracer for the pathways in the central nervous system of the rat. The viruses have been inoculated in various peripheral structures innervated by the trigeminal nerve, namely in the cornea by instillation or scarification, in the anterior chamber of the eye by injection and als...

journal_title：Brain research

authors： Martin X,Dolivo M

更新日期：1983-08-29 00:00:00

abstract：:Murine urocortin 3 (mUcn 3), a member of the corticotropin releasing factor (CRF) peptide family, was recently identified. Of known agonists, this neuropeptide displays the highest degree of selectivity in binding to the CRF(2) receptor. These experiments sought to test the hypothesis that CRF(2) receptors have a role...

journal_title：Brain research

authors： Valdez GR,Zorrilla EP,Rivier J,Vale WW,Koob GF

更新日期：2003-08-08 00:00:00

abstract：:The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...

journal_title：Brain research

authors： Peters S,Kreulen DL

更新日期：1984-06-11 00:00:00

abstract：:The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...

journal_title：Brain research

authors： Copack PB,Lieberman JS,Gilman S

更新日期：1975-09-12 00:00:00

abstract：UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...

journal_title：Brain research

authors： Kapcala LP

更新日期：1986-02-05 00:00:00

abstract：:It has been shown that 2-deoxy-D-glucose (2-DG) inhibits glucose utilization and elicits feeding through the lateral hypothalamus. In contrast, 2,5-anhydro-D-mannitol (2,5-AM), blocking glycogenolysis and/or gluconeogenesis, elicits feeding through the ventromedial hypothalamus. The aim of the present study was to det...

journal_title：Brain research

authors： Morita H,Fujimoto K,Sakata T,Kurokawa M,Yoshimatsu H,Noda T,Iwakiri R,Sakai T

更新日期：1996-05-06 00:00:00

abstract：:Unanesthetized adult male rats with indwelling right atrial cannulae were used in the majority of experiments. Morphine (MOR, 3.0 mg/kg) caused a large but transient increase in both GH and PRL levels, which could be prevented with naloxone. Disruption of central noradrenergic function with diethyldithiocarbamate (400...

journal_title：Brain research

authors： Koenig J,Mayfield MA,Coppings RJ,McCann SM,Krulich L

更新日期：1980-09-22 00:00:00

abstract：:The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational ag...

journal_title：Brain research

authors： Houdou S,Kuruta H,Hasegawa M,Konomi H,Takashima S,Suzuki Y,Hashimoto T

更新日期：1991-08-16 00:00:00

abstract：:Tyrosine kinase B (TrkB) levels in the adult guinea pig cochlear nucleus (CN) were determined from Western blots for up to 60 days after unilateral cochlear ablation (UCA). Compared to TrkB levels on the intact side, those on the lesioned side were elevated in the anteroventral CN (AVCN) at 7 and 60 days and in the po...

journal_title：Brain research

authors： Suneja SK,Potashner SJ

更新日期：2002-12-13 00:00:00

abstract：UNLABELLED:The effects of acute and chronic exposure to phencyclidine (PCP) on the regulation of prolactin (PRL) secretion were examined. Female Sprague-Dawley rats were injected with PCP (10 mg/kg) or saline for 14 days, or just prior to the administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP). A sin...

journal_title：Brain research

authors： Hyde JF

更新日期：1992-02-28 00:00:00

abstract：:Changes in the activity and amount of the neurotransmitter synthesizing enzyme tyrosine hydroxylase (TH) were measured in dopaminergic (DA) neurons of the A10-mesolimbic system of the rat following electrolytic lesions of their axons. Unilateral hypothalamic lesions in close proximity to the cell bodies resulted, with...

journal_title：Brain research

authors： Gilad G,Reis DJ

更新日期：1978-06-23 00:00:00

abstract：:The monovalent lithium ion inhibits the enzyme myo-inositol-1-phosphatase at concentrations comparable to those which are useful in the treatment of manic depressive illness. However, dialyzed cortical homogenates from rats which have been fed diets containing lithium carbonate demonstrate increased myo-inositol-1-pho...

journal_title：Brain research

authors： Renshaw PF,Joseph NE,Leigh JS Jr

更新日期：1986-08-20 00:00:00

abstract：:We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...

journal_title：Brain research

authors： Shin C,Rigsbee LC,McNamara JO

更新日期：1986-11-29 00:00:00

abstract：:This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...

journal_title：Brain research

authors： Tsitolovsky LE,Babkina NV

更新日期：1992-11-06 00:00:00

abstract：:The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...

journal_title：Brain research

authors： McAllister JP 2nd,Cober SR,Schaible ER,Walker PD

更新日期：1989-01-09 00:00:00