Chronic dietary lithium induces increased levels of myo-inositol-1-phosphatase activity in rat cerebral cortex homogenates.

Abstract:

:The monovalent lithium ion inhibits the enzyme myo-inositol-1-phosphatase at concentrations comparable to those which are useful in the treatment of manic depressive illness. However, dialyzed cortical homogenates from rats which have been fed diets containing lithium carbonate demonstrate increased myo-inositol-1-phosphate phosphatase activity. Over a 4-week period, there is an approximate doubling of the lithium-sensitive myo-inositol-1-phosphatase activity in the homogenate.

journal_name

Brain Res

journal_title

Brain research

authors

Renshaw PF,Joseph NE,Leigh JS Jr

doi

10.1016/0006-8993(86)90245-3

subject

Has Abstract

pub_date

1986-08-20 00:00:00

pages

401-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)90245-3

journal_volume

380

pub_type

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