Abstract:
:An immunohistochemical investigation of the bovine pineal gland was performed using both a rabbit polyclonal antibody and a rat monoclonal antibody against choline acetyltransferase (ChAT). A network of ChAT-immunoreactive (IR) nerve fibers was located throughout the pineal gland, both in the perivascular spaces and between the pinealocytes. Most of the intrapineal ChAT-IR nerve fibers were endowed with varicosities. In addition, some ChAT-IR intrapineal neurons were found, often located at the base of the gland near the pineal recess. Within the habenular nucleus and pineal stalk, ChAT-IR perikarya and nerve fibers were also present. Some of these fibers projected towards the pineal gland. A number of ChAT-IR nerves were also located in the posterior commissure and could be followed into the gland. At the caudal tip of the pineal gland, a bundle of ChAT-IR nerve fibers was observed to penetrate into the gland together with blood vessels. The presence of a cholinergic innervation of the bovine pineal gland, together with previous demonstration of the presence of choline acetyltransferase and muscarinic receptor binding sites in the bovine pineal gland, indicates a functional influence of a cholinergic nervous system on the pinealocyte.
journal_name
Brain Resjournal_title
Brain researchauthors
Phansuwan-Pujito P,Mikkelsen JD,Govitrapong P,Møller Mdoi
10.1016/0006-8993(91)91268-6subject
Has Abstractpub_date
1991-04-05 00:00:00pages
49-58issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91268-6journal_volume
545pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02381-7
更新日期:2000-06-30 00:00:00
abstract::Twelve weeks after focal ventrolateral cerebrocortical suction lesions (ca. 12 X 4 mm) were made in rats, concentrations of the monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their metabolites were measured in several cortical and subcortical brain regions using high performance liquid chromat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90796-6
更新日期:1985-10-07 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90442-4
更新日期:1980-09-15 00:00:00
abstract::The effects of cocaine administration and withdrawal on D1 and D2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agoni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90255-0
更新日期:1994-01-14 00:00:00
abstract::Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospho-lipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer'...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146484
更新日期:2019-12-15 00:00:00
abstract::A monospecific antibody against tyrosine hydroxylase (TH), purified from a transplantable rat pheochromocytoma, was produced in rabbits. Immunohistochemical techniques were employed in order to determine if a relationship exists between the subcellular distribution of TH and the level of activation of the enzyme in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90158-x
更新日期:1981-03-30 00:00:00
abstract::The aim of the present study was to investigate the effects of ischemic preconditioning on infarct volume in a rat model of subdural hematoma (SDH). Ischemic preconditioning was induced by 15 min transient middle cerebral artery (MCA) occlusion followed 3 days later by the injection of 300 microl of autologous venous ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03406-0
更新日期:2002-03-15 00:00:00
abstract::The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90706-3
更新日期:1989-05-29 00:00:00
abstract::The highly rigid and conformationally extended 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)-cyclobutane-1-carboxylic acid (cyclobutylene AP5) was synthesized and found to inhibit evoked responses in the rat lateral perforant path (LPP) with an IC50 of 41 (+/- 1.5 S.E.M.) microM a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90525-e
更新日期:1992-01-31 00:00:00
abstract::The dentato-olivary projection has been ultrastructurally studied in rats that received a wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) injection in the nucleus lateralis. Ultrathin sections containing the inferior olive have been double-labelled with the GABA-immunogold method. About 97% of the WGA-HRP labell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91641-7
更新日期:1989-02-13 00:00:00
abstract::Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91596-4
更新日期:1987-12-01 00:00:00
abstract::The same cells in both the intact retina and retinal cultures of the rabbit retina take up exogenous serotonin or 5,7-dihydroxytryptamine. Both substances can be localised by immunohistochemistry using a monoclonal antibody directed against serotonin. The 5,7-dihydroxytryptamine can also be revealed directly in both f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90125-3
更新日期:1986-09-10 00:00:00
abstract::Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91202-c
更新日期:1991-10-18 00:00:00
abstract::Intravenous administration of the cholecystokinin (CCK) antagonist lorglumide (LORG) reversed chronic haloperidol (CHAL)-induced depolarization inactivation (DI) of dopamine (DA) cells in both the A9 and A10 areas. Moreover, microinjection of LORG, but not naloxone, directly into the medial nucleus accumbens (mNAc) do...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90330-7
更新日期:1988-11-08 00:00:00
abstract::Dissociated striatal neurons exhibited increased neurite outgrowth when co-cultured with myenteric plexus explants. Enriched enteric neurons or enriched enteric glia produced a less marked response; non-ganglionic cells had no effect. Increases in striatal neuron and glial cell numbers were seen in all co-cultures. Te...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91137-1
更新日期:1994-06-20 00:00:00
abstract::Electrical self-stimulation in the lateral hypothalamus was recorded in both hemispheres of 20 rats before and after making a lesion either by unilateral radiofrequency stimulation or by injection of N-methyl-D,L-aspartate into the region of the peduncular-pontine nucleus. For the animals which received the radiofrequ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90836-6
更新日期:1989-05-22 00:00:00
abstract::Stellate ganglion block (SGB) is a blockade of sympathetic ganglia innervating the head and neck, and is known to function through vasodilation of the target region. However, the effectiveness of SGB in relieving cerebral vasospasm (CVS) through dilation of intracerebral vessels has not been evaluated. The aim of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.08.012
更新日期:2014-10-17 00:00:00
abstract::Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these funct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.010
更新日期:2010-01-22 00:00:00
abstract::A hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal cord has been well documented and recently related to states of pain and analgesia. In order to study the action of the neuropeptide oxytocin (OT) on pain-related responses, we compared dorsal horn neuronal responses to electric...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.03.020
更新日期:2005-05-31 00:00:00
abstract::The local cerebral circulatory and metabolic effects of MK-801, a selective non-competitive N-methyl-D-aspartate receptor antagonist have been examined in conscious rats with quantitative autoradiographic techniques using [14C]iodoantipyrine and [14C]2-deoxyglucose as tracers. Local cerebral blood flow (CBF) and local...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90172-8
更新日期:1990-03-19 00:00:00
abstract::Evidence from a number of sources indicates that the major site of pro-opiomelanocortin (POMC)-producing cells in the CNS is the arcuate nucleus of the hypothalamus. Using immunocytochemical techniques, a second, smaller group of POMC cells has been detected in the nucleus tractus solitarius (NTS) area of the caudal m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91007-2
更新日期:1992-08-07 00:00:00
abstract::Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90628-2
更新日期:1988-12-20 00:00:00
abstract::Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02682-2
更新日期:2000-09-22 00:00:00
abstract::We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91344-7
更新日期:1994-12-05 00:00:00
abstract::Natural stimulation was used to map the receptive fields of single cells recorded from the rostral medial portion of the dorsal accessory olive (rDAO) and the subjacent principal olive (PO) of the barbiturate anesthetized cat. Previous reports indicated a somatotopic mapping of the entire contralateral body within the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91742-b
更新日期:1993-03-12 00:00:00
abstract::A quantitative study of Wallerian degeneration was carried out on teased fibres. The breakdown into ovoids was used as the criterion of degeneration. The fragmentation of fibres begins near the point of nerve interrruption and spreads along the unbranched parts of axons at velocities correlated with fibre diameter and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90841-1
更新日期:1977-07-08 00:00:00
abstract::The ventral tegmental area is a site of action by psychostimulants in the production of behavioral sensitization. Recently, G proteins of the ventral tegmental area have been implicated in behavioral sensitization to cocaine. To further investigate the specific role of G proteins, rats were treated with either 15 or 3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90049-f
更新日期:1992-05-08 00:00:00
abstract::Transplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved functional outcome. Mechanisms suggested to account for this functional improvement include axonal regeneration, remyelination and neuroprotection. OECs transplanted into transected peripheral nerve have been shown to mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.089
更新日期:2006-12-13 00:00:00
abstract::Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.023
更新日期:2015-11-02 00:00:00
abstract::Primary cultures of astrocytes exhibit a polygonal morphology, but on treatment with agents that increase cAMP they change to stellate cells. We found that astrocyte stellation also occurred on replacing the culture medium with saline buffered with HEPES. However, stellation did not occur when the medium was replaced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02819-6
更新日期:2002-08-09 00:00:00