Abstract：
:Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesting that behavioral sensitization and conditioned locomotion may share a requirement for NMDA receptor stimulation. Repeated MK-801 administration produced behavioral sensitization to MK-801 but not amphetamine challenge, suggesting that MK-801 itself produces sensitization through a different mechanism than amphetamine.
journal_name
Brain Resjournal_title
Brain researchauthors
Wolf ME,Khansa MRdoi
10.1016/0006-8993(91)91202-csubject
Has Abstractpub_date
1991-10-18 00:00:00pages
164-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)91202-Cjournal_volume
562pub_type
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