Abstract：
:The developmental time course and life span of the human brain are different from those of laboratory animals. These variations may be the reflection of metabolic differences of the neurons between different species. Using immunocytochemistry, we show that pyramidal neurons accumulate advanced glycosylation end products (AGEPs) formed by the Maillard reaction. However, the patterns of AGEPs accumulation in the pyramidal neuron were quite distinct between human and the 4 different animal species (horse, calf, pig, and rat) examined. In the human pyramidal neuron, AGEPs depict a granular, perikaryonal distribution, whereas in the animal brains, AGEPs show a nuclear staining pattern. The different patterns of AGEPs distribution in the pyramidal neurons suggest that AGEPs is an in vivo biochemical marker which distinguishes human pyramidal neurons from those of animals, and may help characterise pathologies specific to human.
journal_name
Brain Resjournal_title
Brain researchauthors
Li JJ,Voisin D,Quiquerez AL,Bouras Cdoi
10.1016/0006-8993(94)90156-2subject
Has Abstractpub_date
1994-04-04 00:00:00pages
285-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90156-2journal_volume
641pub_type
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