Differential expression of advanced glycosylation end-products in neurons of different species.


:The developmental time course and life span of the human brain are different from those of laboratory animals. These variations may be the reflection of metabolic differences of the neurons between different species. Using immunocytochemistry, we show that pyramidal neurons accumulate advanced glycosylation end products (AGEPs) formed by the Maillard reaction. However, the patterns of AGEPs accumulation in the pyramidal neuron were quite distinct between human and the 4 different animal species (horse, calf, pig, and rat) examined. In the human pyramidal neuron, AGEPs depict a granular, perikaryonal distribution, whereas in the animal brains, AGEPs show a nuclear staining pattern. The different patterns of AGEPs distribution in the pyramidal neurons suggest that AGEPs is an in vivo biochemical marker which distinguishes human pyramidal neurons from those of animals, and may help characterise pathologies specific to human.


Brain Res


Brain research


Li JJ,Voisin D,Quiquerez AL,Bouras C




Has Abstract


1994-04-04 00:00:00














  • Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats.

    abstract::Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nagahara AH,Gill TM,Nicolle M,Gallagher M

    更新日期:1996-01-22 00:00:00

  • The enteric nervous system in tissue culture. II. Ultrastructural studies of cell types and their relationships.

    abstract::Tissue culture preparations of the myenteric plexus from the guinea pig taenia coli have been studied by electron microscopy. Three main cell types can be identified: neurons, enteric glial cells and fibroblasts. The ultrastructure of these cells resembles that of the same cells in situ. Neuronal processes form close ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bałuk P,Jessen KR,Saffrey MJ,Burnstock G

    更新日期:1983-02-28 00:00:00

  • Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5.

    abstract::Protease-activated receptors (PARs), G-protein-coupled receptors, are widely expressed in various tissues, where they participate in physiological and pathological processes, such as hemostasis, proliferation, tissue repair, and inflammation. Recently, we found that PARs were upregulated in the rat retina following op...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Luo W,Wang Y,Reiser G

    更新日期:2005-06-21 00:00:00

  • Basic fibroblast growth factor-like immunoreactivity in the trigeminal proprioceptive and motor systems.

    abstract::Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matsuda S,Desaki J,Okumura N,Shiosaka S,Imaoka S,Sakanaka M

    更新日期:1992-04-10 00:00:00

  • Projection from the prefrontal cortex to histaminergic cell groups in the posterior hypothalamic region of the rat. Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunocytochemistry of histidine decarboxylase.

    abstract::We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined PHA-L and histidine dec...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wouterlood FG,Steinbusch HW,Luiten PG,Bol JG

    更新日期:1987-03-17 00:00:00

  • Immunoreactive avian pancreatic polypeptide in the chicken retina: overall distribution.

    abstract::The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Katayama Y,Kiyama H,Arai Y,Tohyama M

    更新日期:1984-09-17 00:00:00

  • Visual stimulation increases regional cerebral blood flow and metabolism in the goldfish.

    abstract::Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Altenau LL,Agranoff BW

    更新日期:1979-01-26 00:00:00

  • Lack of Galectin-3 attenuates neuroinflammation and protects the retina and optic nerve of diabetic mice.

    abstract::Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mendonça HR,Carvalho JNA,Abreu CA,Mariano de Souza Aguiar Dos Santos D,Carvalho JR,Marques SA,da Costa Calaza K,Martinez AMB

    更新日期:2018-12-01 00:00:00

  • Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo.

    abstract::Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: He LF,Chen HJ,Qian LH,Chen GY,Buzby JS

    更新日期:2010-06-21 00:00:00

  • Response to repetitive stimulation of AMPA receptors in patches excised from fields CA1 and CA3 of the hippocampus.

    abstract::Patches excised from fields CA1 and CA3 of the hippocampus were used to study AMPA receptor responses to repetitive application of brief pulses of agonist. AMPA receptors in field CA1 exhibited a larger degree of paired-pulse depression and a slower recovery rate from desensitization than those from CA3 patches. Respo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Arai A,Lynch G

    更新日期:1996-04-15 00:00:00

  • The basis and functional role of the late EMG activity in human forearm muscles following wrist displacement.

    abstract::The present paper examines the hypothesis that the long latency EMG activity produced by muscle stretch is the result of long loop reflex pathways involved in the control of limb stiffness. We recorded the cerebral responses and late EMG activity in agonist and antagonist muscles following sudden stretch of the wrist ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Goodin DS,Aminoff MJ

    更新日期:1992-08-28 00:00:00

  • Tryptophan hydroxylase mRNA levels are regulated by the circadian clock, temperature, and cAMP in chick pineal cells.

    abstract::Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Green CB,Besharse JC,Zatz M

    更新日期:1996-10-28 00:00:00

  • Involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in the rat.

    abstract::The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was su...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ardid D,Jourdan D,Mestre C,Villanueva L,Le Bars D,Eschalier A

    更新日期:1995-10-16 00:00:00

  • Ontogeny of immunoreactive gonadotropin-releasing hormone neuronal systems in amphibians.

    abstract::The ontogeny of gonadotropin-releasing hormone (GnRH) systems was investigated in 3 anuran amphibians (genus Rana) by means of immunocytochemical (ICC) techniques and antibodies generated against 3 different forms of GnRH. Antisera that recognize primarily chicken II and mammalian GnRHs revealed two anatomically and d...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Muske LE,Moore FL

    更新日期:1990-11-26 00:00:00

  • Effect of acidosis on lipid peroxidation in brain slices.

    abstract::Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bralet J,Bouvier C,Schreiber L,Boquillon M

    更新日期:1991-01-18 00:00:00

  • corticofugal regulation of excitatory and inhibitory frequency tuning curves of bat inferior collicular neurons.

    abstract::Corticofugal regulation of excitatory and inhibitory frequency tuning curves (FTCs) of neurons in the central nucleus of bat inferior colliculus (ICc) was studied by electrical stimulation of the primary auditory cortex (AC stimulation) under free field stimulation conditions using a two-tone inhibition paradigm. AC s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jen PH,Zhang JP

    更新日期:1999-09-11 00:00:00

  • Cadmium exposure attenuates the initiation of behavioral sensitization to cocaine.

    abstract::Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nation JR,Livermore CL,Bratton GR

    更新日期:1995-12-08 00:00:00

  • Effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of dorsal root ganglion neurons in a neuropathic pain model.

    abstract::We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Honma Y,Yamakage M,Ninomiya T

    更新日期:1999-06-19 00:00:00

  • Ontogeny of somatostatin-containing neuron system of the rat cerebellum including its fiber connections: an experimental and immunohistochemical analysis.

    abstract::Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Inagaki S,Shiosaka S,Takatsuki K,Iida H,Sakanaka M,Senba E,Hara Y,Matsuzaki T,Kawai Y,Tohyama M

    更新日期:1982-04-01 00:00:00

  • Role of the amygdala in ethanol withdrawal seizures.

    abstract::Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Feng HJ,Yang L,Faingold CL

    更新日期:2007-04-13 00:00:00

  • Antidromic discharges in dorsal roots of decerebrate cats. II: studies during treadmill locomotion.

    abstract::In a previous companion paper [Brain Res. 846 (1999) 87-105] we have shown that the dorsal root activity of a decerebrate cat is composed of both orthodromic and antidromic discharges as determined by spike triggered averaging (STA). Furthermore we have shown that, during fictive locomotion in decerebrate and paralyze...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Beloozerova IN,Rossignol S

    更新日期:2004-01-23 00:00:00

  • Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age.

    abstract::Although there are indications of growth in the size and myelination of the rat corpus callosum during adulthood, it is not known how long this growth continues. In addition, the potential for age-related changes in these measures to affect the sex differences seen in adulthood has not been examined. Here the size of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yates MA,Juraska JM

    更新日期:2007-04-20 00:00:00

  • The projection from striate and extrastriate cortical areas to the superior colliculus in the rat.

    abstract::Following single injections of horseradish peroxidase (HRP) in the superior colliculus (SC) and [3H]proline in the striate cortex of rats, a close correspondence was observed in the topographical arrangements of extrastriate cortical fields of HRP retrograde label and of isotope anterograde label. These results suppor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Olavarria J,Van Sluyters RC

    更新日期:1982-06-24 00:00:00

  • Neuron-specific enolase-like immunoreactivity in inner hair cells but not outer hair cells in the guinea pig organ of Corti.

    abstract::Neuron-specific enolase (NSE) has been localized only in neurons and cells with characteristics of neurons. The immunocytochemical localization of NSE was examined in guinea pig cochleae to determine if hair cells, which have some neuronal characteristics, would show NSE-like immunoreactive labeling. NSE-like immunore...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Altschuler RA,Reeks KA,Marangos PJ,Fex J

    更新日期:1985-02-18 00:00:00

  • Identification of vasopressin in the subfornical organ region: effects of dehydration.

    abstract::The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Summy-Long JY,Keil LC,Severs WB

    更新日期:1978-01-27 00:00:00

  • Ascending dopaminergic projections from the dorsal raphe nucleus in the rat.

    abstract::The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Stratford TR,Wirtshafter D

    更新日期:1990-03-12 00:00:00

  • Phonological code retrieval during picture naming: Influence of consonant class.

    abstract::Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cummings A,Seddoh A,Jallo B

    更新日期:2016-03-15 00:00:00

  • Calcitonin gene-related peptide- and substance P-containing primary afferent fibers in the dorsal column of the rat.

    abstract::The dorsal column and its nuclei exhibit a considerable number of fibers containing neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP), whose origins and functional roles are as yet unknown. The present study attempts to determine the origin and nature of these fibers by means of immuno...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tamatani M,Senba E,Tohyama M

    更新日期:1989-08-21 00:00:00

  • Glycine elicits release of acetylcholine from the nucleus tractus solitarii in rat.

    abstract::Previous studies have suggested that cardiovascular responses elicited by injection of glycine into the nucleus tractus solitarii (NTS) depend upon interactions between glycinergic and cholinergic neuronal elements in NTS. Release of acetylcholine in response to glycine is one such interaction that has been shown in s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Talman WT,Wellendorf L,Martinez D,Ellison S,Li X,Cassell M,Ohta H

    更新日期:1994-07-11 00:00:00

  • Conformational changes of opioid receptor induced by the electric footshock.

    abstract::The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nabeshima T,Matsuno K,Kameyama T

    更新日期:1985-09-16 00:00:00