Abstract：
:Clusters of carotid body (glomus) cells cultured from a few days to 3 weeks, maintained their morphological characteristics during this period. The resting potential (Em) and input resistance (Ro) did not change for 2 weeks but both declined afterwards. The intracellular pH (pHi) of glomus cells, measured with glass microelectrodes filled with an H+ ion exchanger, was 6.34-6.96 at extracellular pH (pHo) of 7.32-7.53. Changes in pHo from normal to about 5.5 depolarized most cells but the fall in pHi was less marked than predicted by the Nernst equation. Conversely, shifting pHo to 8.5 hyperpolarized the cells with an increase in pHi which was more acid than predicted. EH (the calculated equilibrium potential for H+ (Nernst equation) was more positive than Em during acidity and more negative during normal or alkaline pHo. The kinetics of H+ ion distribution was assessed by brief exposures to NH4Cl. It is concluded that hydrogen ions are not passively distributed across the glomus cell membranes and that Em is dependent on H+ ions.
journal_name
Brain Resjournal_title
Brain researchauthors
He SF,Wei JY,Eyzaguirre Cdoi
10.1016/0006-8993(91)90969-3subject
Has Abstractpub_date
1991-05-03 00:00:00pages
258-66issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90969-3journal_volume
547pub_type
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