Abstract：
:We cloned the genes for the mouse homologue of the neuromedin B receptor (NMB-R) and the bombesin receptor subtype 3 (BRS-3). Both receptor genes consist of three exons with well-conserved intron-exon borders. Although the NMB-R gene spans more than 10 kb, the BRS-3 gene spans only about 4 kb. Comparison of the mouse and human receptor sequences indicates 90% (NMB-R) and 85% (BRS-3) sequence homology at the amino-acid level. In the adult mouse, the NMB-R mRNA is expressed in the brain, testis, esophagus, intestine and uterus, whereas the BRS-3 mRNA is expressed predominantly in the brain. In the brain, the NMB-R gene expression is prominent in the thalamic and olfactory regions, and the BRS-3 gene is expressed particularly in the hypothalamic region. In mouse testis, the NMB-R gene expression is prominent, and the expression of BRS-3 mRNA is barely detected. In contrast, BRS-3 has been shown to be expressed in rat testis and guinea-pig uterus, therefore it is possible that a different subtype of the bombesin receptor mediates the same response in different species. Together with the mouse GRP-R gene cloned previously, cloning of the mouse NMB-R and BRS-3 genes permits comparison of function and structure of the three bombesin receptor subtypes in the mouse.
journal_name
Brain Resjournal_title
Brain researchauthors
Ohki-Hamazaki H,Wada E,Matsui K,Wada Kdoi
10.1016/s0006-8993(97)00380-6subject
Has Abstractpub_date
1997-07-11 00:00:00pages
165-72issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00380-6journal_volume
762pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90242-2
更新日期：1985-07-08 00:00:00
abstract：:Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90771-x
更新日期：1976-07-30 00:00:00
abstract：:The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91463-0
更新日期：1986-04-30 00:00:00
abstract：:Electrical stimulation of the subfornical organ (SFO) in urethane anesthetized male Sprague-Dawley rats was associated with intensity and frequency dependent increases in arterial blood pressure. Stimulation in the hypothalamic paraventricular nucleus (PVN) also evoked increases in arterial blood pressure. Electrolyti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90443-8
更新日期：1984-07-09 00:00:00
abstract：:We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91136-x
更新日期：1987-06-02 00:00:00
abstract：:The aim of this study was to determine the effect of different concentrations of normobaric oxygen (NBO) on neurological function and the expression of caspase-3 and -9 in a rat model of acute cerebral ischaemia. Sprague-Dawley rats (n=120) were randomly divided into four groups (n=30 per group), including 3 groups gi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.05.027
更新日期：2015-08-27 00:00:00
abstract：:Carbonic anhydrase (CA) and cholinesterase (CE) histochemical staining of rabbit spinal nerve roots and dorsal root ganglia demonstrated that among the reactive myelinated axons, with minor exceptions, sensory axons were CA positive and CE negative whereas motor axons were CA negative and CE positive. The high specifi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90145-x
更新日期：1988-06-21 00:00:00
abstract：:When one eye of a rat is removed at birth an increased projection to the brain is found from the remaining eye. This projection arises from the whole retina and mainly from ganglion cells which project to only one hemisphere of the brain. In the normal course of development many of these cells die and the uncrossed pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90069-9
更新日期：1981-08-01 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.07.039
更新日期：2014-09-25 00:00:00
abstract：:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90327-6
更新日期：1992-06-05 00:00:00
abstract：:An HRP study of the frog's superior olivary nucleus (SON) revealed that it (1) receives reciprocal tonotopic projections from dorsal medullary nuclei and principal nuclei of the torus semicircularis (TS) bilaterally; (2) receives bilateral projections from caudalis nuclei and brainstem reticular nuclei, and unilateral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90998-4
更新日期：1986-01-29 00:00:00
abstract：:The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90439-3
更新日期：1989-06-19 00:00:00
abstract：:A mutation in the Vps33a gene causes Hermansky-Pudlak Syndrome (HPS)-like-symptoms in the buff (bf) mouse mutant. The encoded product, Vps33a, is a member of the Sec1 and Class C multi-protein complex that regulates vesicle trafficking to specialized lysosome-related organelles. As Sec1 signaling pathways have been im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.035
更新日期：2009-04-17 00:00:00
abstract：:To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91280-6
更新日期：1993-08-06 00:00:00
abstract：:The hypothalamic angiotensin II (Ang II) system plays an important role in pituitary hormone release. Little is known about this system in the mouse brain. We studied the distribution of angiotensin-converting-enzyme (ACE), Ang II, Ang II receptor subtypes, and vasopressin in the hypothalamus of adult male mice. Autor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00220-5
更新日期：1997-05-23 00:00:00
abstract：:Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91212-7
更新日期：1988-09-13 00:00:00
abstract：:The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90330-1
更新日期：1987-05-05 00:00:00
abstract：:The present experiments describe the effect of NMDA and kainate agonists of the NMDA and non-NMDA subtype of receptors respectively of the excitatory amino acids (EAAs) system in prepubertal (16 days of age) and peripubertal (30-day-old rats) male rats on the in vitro hypothalamic release of GnRH, and on the in vivo L...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01216-8
更新日期：1996-01-29 00:00:00
abstract：:We sought to identify the areas that have altered neuronal activity within the hypothalamus of rats with heart failure (HF) by mapping neuronal staining of c-Fos protein (Fos) 6-8 weeks following coronary artery ligation (HF group; n=17) or sham surgery (sham-operated control group, n=15). Fos-like immunoreactivity wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02186-7
更新日期：2000-05-19 00:00:00
abstract：:Previous immunocytochemical studies have shown immunological differences between neurofilaments in axons and those in dendrites and perikarya of many mature neuron types: it is now known that non-phosphorylated epitopes are normally seen in cell bodies and dendrites of mature neurons, whereas phosphorylated epitopes a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90367-8
更新日期：1988-09-20 00:00:00
abstract：UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90357-5
更新日期：1988-07-19 00:00:00
abstract：:Despite over 20 years of behavioral research, considerable disagreement remains regarding the locus of the cognitive mechanisms (e.g., stimulus encoding, response selection or response production) responsible for the acquisition and expression of learned sequences. Functional neuroimaging may prove invaluable for reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.097
更新日期：2009-01-09 00:00:00
abstract：:Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.07.018
更新日期：2018-12-01 00:00:00
abstract：:Among the many pathophysiologic consequences of traumatic brain injury are changes in catecholamines, including dopamine, epinephrine, and norepinephrine. In the context of TBI, dopamine is the one most extensively studied, though some research exploring epinephrine and norepinephrine have also been published. The pur...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.12.026
更新日期：2016-06-01 00:00:00
abstract：:In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91309-0
更新日期：1986-02-26 00:00:00
abstract：:Methionine (Met) enkephalin is detectable in rat hypothalamic and neurointermediate lobe (NIL) tissue extracts using a specific radioimmunoassay. Reversed-phase HPLC revealed that only the pentapeptide form was present in the extracts. Total amounts of Met-enkephalin in extracts containing the median eminence (ME), su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90895-i
更新日期：1990-05-14 00:00:00
abstract：:A study was made of the effects of electrochemically stimulating (ECS) and destroying the midbrain dorsal and median raphe nuclei on the estrogen-progesterone- (EP) induced surge of pituitary LH release in ovariectomized rats. ECS and lesions were produced simultaneously with anodal direct current through a chronicall...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90006-8
更新日期：1981-08-03 00:00:00
abstract：:Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02351-4
更新日期：2001-07-13 00:00:00
abstract：:The purpose of this study is to reveal whether the application of immunohistochemical examinations to the peripheral nervous system (PNS) can be a reliable method for the quantitative analysis of the blood-nerve barrier (BNB) and the relationship between restoration of BNB and nerve regeneration. Sciatic nerves in rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.067
更新日期：2004-03-19 00:00:00
abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.031
更新日期：2010-06-04 00:00:00
